Back to the beginning: can we stop brain injury before it starts?

Davidson, J.; Gunn, Alistair J.; Dean, Justin M.

doi:10.1113/jp283330

Cited by 2 publications

(2 citation statements)

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“…The present data suggest that there may be a critical Cr demand immediately after birth that needs to be covered by both neosynthesis and increased enteral supply via colostrum. Several preclinical studies have suggested that Cr is a promising neuroprotective intervention for hypoxic ischemic injury [27][28][29][30]. In vitro Cr plays a role in protecting cultured rat cardiomyocytes from hypoxic stress by enhancing the expression of hypoxiainducible factor 1 (HIF-1), a master regulator of various anti-apoptotic mechanisms, as well as erythrocyte production [52].…”

Section: Longitudinal Study On Breast Milk Creatinementioning

confidence: 99%

“…Placental Cr content and Cr transporter mRNA expression sharply increased in fetal growth restriction compared to controls, without affecting maternal plasma Cr or venous cord blood Cr. Several preclinical studies have suggested that Cr is a promising neuroprotective intervention for hypoxic ischemic injury [26][27][28][29][30]. However, fetal and preterm infant Cr metabolism are largely unknown [26].…”

Section: Introductionmentioning

confidence: 99%

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The Umbilical Cord Creatine Flux and Time Course of Human Milk Creatine across Lactation

Mihatsch,

Stahl,

Braun

2024

Nutrients

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(1) Background: The aim of the present paper was to study fetal and infant creatine (Cr) supply to improve nutrition and neuroprotection in term and especially in preterm infants. The primary outcomes were the placental Cr flux at the end of pregnancy and the time course of human milk (HM) Cr. (2) Methods: The estimation of placental Cr flux was based on umbilical arterial and venous cord blood Cr in 10 term infants after elective caesarian section. HM Cr, creatinine (Crn), and macronutrients were measured longitudinally in 10 mothers across the first 6 months of breastfeeding. (3) Results: At the end of pregnancy, the mean fetal Cr flux was negative (−2.07 mmol/min). HM Cr was highest in colostrum, decreased significantly within the first 2 weeks of breastfeeding (p < 0.05), and did not change significantly thereafter. HM Cr was not correlated with HM Crn or macronutrient composition. (4) Conclusions: The present data suggest that fetal endogenous Cr synthesis covers the needs at the end of pregnancy. However, high colostrum Cr and HM Cr levels, independent of macronutrient composition, suggest that there may be a critical Cr demand immediately after birth that needs to be covered by enteral supply.

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