Back to the roots – dermatology in ancient Egyptian medicine

Hartmann, Anke

doi:10.1111/ddg.12947

Cited by 17 publications

(20 citation statements)

References 19 publications

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“…The use of topical products to treat skin conditions goes back thousands of years, where, for instance, the ancient Egyptians used honey as a treatment for wounds [6]. In the 18th and 19th centuries, dermatologists developed emollients, such as ointments and creams, for the treatment of dry, scaly skin [7].…”

Section: Introductionmentioning

confidence: 99%

Targeted dry skin treatment using a multifunctional topical moisturizer

Stettler

Crowther²,

Brandt

et al. 2021

Intern J of Cosmetic Sci

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Objective The development of dry skin is a complex process, with a wide variety of factors each playing different roles in its evolution. Given this, it is important when designing a formulation to tackle dry skin that these varied aspects of skin behaviour are addressed. Presented here are the results of a 3‐week moisturization study carried out on dry legs. A wide range of traditional and more recently developed biophysical measurement methods have been combined with visual assessment of skin condition to enable multiple aspects of skin function to be determined. The observed changes in the skin are discussed in terms of the ingredients used in the moisturizing formulation. Methods A range of novel and traditional skin assessment methods and techniques were used to assess the effects of an oil in water‐based moisturizing product compared to an untreated site during a 3‐week in vivo study on dry lower leg skin. Results Statistically significant improvements were observed in a range of skin parameters as a result of product usage. Skin hydration assessed using Corneometer®, Epsilon® and visual dry skin grading all increased after 3 weeks of use. Skin barrier function measured using transepidermal water loss also improved. Levels of cholesterol, free fatty acids and Ceramide NH increased, as well as the average length of the stratum corneum (SC) lipid lamella bilayers, and the ratio of lipid to protein increased (measured using Lipbarvis® and in vivo Confocal Raman Spectroscopy). Increases in the levels of Ceramide EOS and NP were also observed, along with an improvement in corneocyte maturity, although these were not statistically significant. Conclusions Using a variety of traditional and novel skin assessment techniques, a wide range of factors associated with the evolution of dry skin have been assessed upon treatment with a new topical moisturizer. Product usage resulted in significant improvements to skin hydration and barrier function, the levels and morphology of SC barrier lipids, and overall epidermal differentiation. As a result there was a significant reduction in the characteristics associated with the development of dry skin after use of the test product.

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Section: Introductionmentioning

confidence: 99%

Targeted dry skin treatment using a multifunctional topical moisturizer

Stettler

Crowther²,

Brandt

et al. 2021

Intern J of Cosmetic Sci

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“…One of the known initially sources detailing skin diseases is the Ebers Papyrus, a medical paper from antique Egypt dating to around 1500 BC. It offers descriptions of the various skin diseases, including ulcers, rashes, and tumours, and prescribes surgery and ointments to treat the ailments [12]. There are two ways of detecting or diagnosing skin disease…”

Section: B Methods Of Identifying Skin Diseasesmentioning

confidence: 99%

A Web-Based Skin Disease Diagnosis Using Convolutional Neural Networks

Akyeramfo-Sam¹,

Philip²,

Yeboah³

et al. 2019

IJITCS

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Skin diseases are reported to be the most common disease in humans among all age groups and a significant root of infection in sub-Saharan Africa. The diagnosis of skin diseases using conventional approaches involves several tests. Due to this, the diagnosis process is seen to be intensely laborious, time-consuming and requires an extensive understanding of the domain. The enhancement of computer vision through artificial intelligence has led to a more straightforward and quicker way of detecting patterns in images, which can be harnessed to equip diagnosis process. Despite the breakthrough in technology, the dermatological process in Ghana is yet to be automated, making the diagnosis process complicated and time-consuming. Hence, this study sought to propose a web-based skin disease detection system named medilab-plus using a convolutional neural network classifier built upon the Tensorflow framework for detecting (atopic dermatitis, acne vulgaris, and scabies) skin diseases. Experimental results of the proposed system exhibited classification accuracy of 88% for atopic dermatitis, 85% for acne vulgaris, and 84.7% for scabies. Again, the computational time (0.0001 seconds) of the proposed system implies that any dermatologist, who decides to implement this study, can attend to not less than 1,440 patients a day compared to the manual diagnosis process. It is estimated that the proposed system will enhance accuracy and offer fasting diagnosis results than the traditional method, which makes this system a trustworthy and resourceful for dermatological disease detection. Additionally, the system can serve as a realtime learning platform for students studying dermatology in medical schools in Ghana.

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“…For example, in 4000 BC, ancient Egyptians had discovered the use of natural resources, such as henna, red ochers and kohl, for skin care and cosmetics [ 53 ]. In 1500 BC, they wrote hundreds of drugs and prescriptions on a papyrus paper, namely Ebers Papyrus (manuscript on medicine) [ 54 ]. One example of the information written in this book was the use of the tiger nut for covering skin wounds [ 54 ].…”

Section: A Brief History Of Transdermal Productsmentioning

confidence: 99%

“…In 1500 BC, they wrote hundreds of drugs and prescriptions on a papyrus paper, namely Ebers Papyrus (manuscript on medicine) [ 54 ]. One example of the information written in this book was the use of the tiger nut for covering skin wounds [ 54 ].…”

Section: A Brief History Of Transdermal Productsmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

284

159

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Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

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Back to the roots – dermatology in ancient Egyptian medicine

Cited by 17 publications

References 19 publications

Targeted dry skin treatment using a multifunctional topical moisturizer

Targeted dry skin treatment using a multifunctional topical moisturizer

A Web-Based Skin Disease Diagnosis Using Convolutional Neural Networks

Enhancement strategies for transdermal drug delivery systems: current trends and applications

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