Backbone charge transport in double-stranded DNA

RNA BioMolecular Electronics: towards new tools for biophysics and biomedicine

“…How the charges move through oligonucleotides is a question that has been addressed using diverse techniques, including bulk and single-molecule approaches, in environments ranging from ultra-high vacuum to solid-state configurations in air, as well as experiments in buffer and electrochemical environments. 33,34,[52][53][54][55][56][57][58][59][60] DNA bases have been found to participate and mediate CT in optical, electrochemical, and single-molecule approaches. 53 However, in a recent study, it is suggested that CT could also be mediated by the backbone.…”

DNA Framework‐Engineered Long‐Range Electrostatic Interactions for DNA Hybridization Reactions

“…[5] Recently,long range charge transport along the backbone of double helical DNAwas observed by direct electrochemical measurements. [6] This finding further realizes long-range electrostatic interactions on DNAr egardless of limitations from the electric double layer, exemplified by proteins such as yeast transcription factor GCN4 mutants,which were able to induce a258 8 bend of the DNAhelix by electrostatic forces. [7] However,t here is still al ack of appropriate models illustrating the complicity of DNA-biomacromoleculei nteractions,o nw hich long-range correlation relies.T he natural protein-nucleic acid complexes usually exhibit specific functions and are easily deactivated by modifications and changes of ac hemical nature.O nt he other hand, artificial macromolecule-DNAc omplexes are usually inadequate in structural complicity in comparison with natural ones.I nt he past decade,fast-developing DNAnanotechnology has constructed increasingly complicated DNAn anostructures.…”

Fine-tuning the DNA conductance by intercalation of drug molecules

“…There has been a recent discussion about the possibility of having electronic transport mediated by the backbones [30], which motivated us to investigate the role of backbone in present study. In Figs.…”

“…DNA has emerged as an integral part of molecular electronics over the past decade [19][20][21]. Several theoretical and experimental works have been done to explore the charge transport properties of DNA [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. Apart from molecular electronics, DNA charge transport has applications in spin specific electron conductors [41] and detection of genetic materials from an ensemble [42].…”