Backbone-Thermoresponsive Hyperbranched Polyethers

Abstract

A new type of materials, the backbone-thermoresponsive hyperbranched polyether, was successfully synthesized by proton-transfer polymerization of 1,4-butanediol diglycidyl ether and various triols, and the lower critical solution temperature (LCST) values can be readily adjusted from 19.0 to 40.3 degrees C by changing the hydrophilic/hydrophobic balance of BDE and triols.

Bioreducible unimolecular micelles based on amphiphilic multiarm hyperbranched copolymers for triggered drug release

“…In the past few years, driven by the need to release drugs quickly in response to an appropriate stimulus, several stimuli-responsive multiarm hyperbranched copolymers responding to temperature, pH, and redox have been synthesized and some of them have also been utilized as smart drug carriers [24][25][26][27][28][29][30][31]. Upon reaching the targeted cells, these drug delivery systems can be rapidly provoked by the stimuli to release the drug, hence inducing aggressive activity within cells and leading to maximal therapeutic efficacy with relatively low side effects [32,33].…”

Thermoresponsive hyperbranched polyethylenimines with isobutyramide functional groups

“…Only very recently, was hyperbranched polymer with a thermoresponsive backbone prepared. 24,25 Isobutyramide (IBAm) groups attached to the side chains of linear polymers 26 or the end groups of dendrimers 12,13 rendered them thermoresponsive properties, thus, in this article, we transformed the end groups of the commercial available hyperbranched polyethylenimine (HPEI) into IBAm groups, which also showed LCST property in aqueous media. This new kind of thermoresponsive hyperbranched polymer with LCST property in aqueous media can be categorized as the first hyperbranched polymer with thermoresponsive terminals.…”

Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

“…[52][53][54][55] As another type of thermosensitive polymers, dendrimers and hyperbranched polymers consisting of thermosensitive polyether backbones have also been developed. 56,57 Dendrimer-based bionanomaterials K Kono…”