Background calcium influx in arrhythmia: lead actor or extra?

Deciphering calcium signals in cells and tissues with tailored probes and models

“…(2022) discussed in Fakuade et al. (2022) and Meier et al. (2022), which shows that basal sarcolemmal Ca 2+ influx via TRPC6 channels causes SR Ca 2+ overload and triggers Ca 2+ waves in sheep ventricular myocytes, and with the recent model by Sato et al.…”

“…It will be particularly interesting to probe the RyR1 coupling of STIM1 loss-of-function and gain-of-function mutations that cause muscular diseases. Readers interested in the potential impact of this circuit for cardiac function can further extend their knowledge with the article by Hutchings et al (2022) discussed in Fakuade et al (2022) and Meier et al (2022), which shows that basal sarcolemmal Ca 2+ influx via TRPC6 channels causes SR Ca 2+ overload and triggers Ca 2+ waves in sheep ventricular myocytes, and with the recent model by Sato et al (2021) showing that increasing SR Ca 2+ load has a biphasic effect on the initiation of arrhythmogenic Ca 2+ waves. The four reviews illustrate simple and enduring values in physiology, namely:…”