2022
DOI: 10.1002/deo2.105
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Background features in the cytology of pancreatic neoplasms

Abstract: Cytology is a useful method for diagnosing pancreatic neoplasms. Although endoscopic ultrasound‐guided fine‐needle aspiration has recently become the mainstream method for the diagnosis of pancreatic neoplasms, pancreatic juice and pancreatic duct brushing cytology continue to be useful diagnostic methods for the investigation of pancreatic neoplasms. Diagnoses using pancreatic cytology are primarily based on the features related to tumor cells; however, evaluation of the background features provides important… Show more

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Cited by 4 publications
(4 citation statements)
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References 55 publications
(120 reference statements)
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“…That is, we identified cases in which the mass had been classified into Category B on the basis of EUS-FNAC but into Category C/D on the basis of EUS-FNAB and vice versa. We then evaluated cytologic features as: background (clear vs. necrotic background) ('clear background' was defined as viable cells with an absence of necrotic tissue; 'necrotic background' was defined as diffuse necrosis complicated with various numbers of conspicuous malignant cells); 15,16 quantity of atypical cells in the sample (few vs. numerous); characteristics of the nuclei, that is, arrangement (regular vs. irregular), atypia (mild, severe (with severe nuclear atypia manifested as anisonucleosis or irregularly shaped nuclei, or uneven distribution of coarse chromatin)); and the nuclear/cytoplasmic (N/C) ratio (<60%, ≥60%). Further, we examined the following histomorphologic features of these masses: background (clear, necrotic), quantity of atypical cells in the sample (few, numerous), atypical glandular structures (few <3, numerous ≥3) cytologic atypia (mild, severe), and atypical cells that appear degenerate or necrotic (few, numerous).…”
Section: Investigation Of Diagnostic Discordance By Evaluation Of Cyt...mentioning
confidence: 99%
“…That is, we identified cases in which the mass had been classified into Category B on the basis of EUS-FNAC but into Category C/D on the basis of EUS-FNAB and vice versa. We then evaluated cytologic features as: background (clear vs. necrotic background) ('clear background' was defined as viable cells with an absence of necrotic tissue; 'necrotic background' was defined as diffuse necrosis complicated with various numbers of conspicuous malignant cells); 15,16 quantity of atypical cells in the sample (few vs. numerous); characteristics of the nuclei, that is, arrangement (regular vs. irregular), atypia (mild, severe (with severe nuclear atypia manifested as anisonucleosis or irregularly shaped nuclei, or uneven distribution of coarse chromatin)); and the nuclear/cytoplasmic (N/C) ratio (<60%, ≥60%). Further, we examined the following histomorphologic features of these masses: background (clear, necrotic), quantity of atypical cells in the sample (few, numerous), atypical glandular structures (few <3, numerous ≥3) cytologic atypia (mild, severe), and atypical cells that appear degenerate or necrotic (few, numerous).…”
Section: Investigation Of Diagnostic Discordance By Evaluation Of Cyt...mentioning
confidence: 99%
“…The imaging features of PDAC at different stag summarized in Figure 1. In addition to diagnosing pancreatic cancer via the cytology/pathology of FNA/FNB specimens, the cytological analysis of the pancreatic juice obtained via can be used to help diagnose pancreatic malignancies [24]. The background cytolog pathological features of pancreatic neoplasms can also be helpful for distingu different types of pancreatic lesions.…”
Section: Current Approaches To Diagnosing Pancreatic Cancermentioning
confidence: 99%
“…The background cytolog pathological features of pancreatic neoplasms can also be helpful for distingu different types of pancreatic lesions. For example, desmoplastic stroma and the pre In addition to diagnosing pancreatic cancer via the cytology/pathology of EUS-FNA/FNB specimens, the cytological analysis of the pancreatic juice obtained via ERCP can be used to help diagnose pancreatic malignancies [24]. The background cytological or pathological features of pancreatic neoplasms can also be helpful for distinguishing different types of pancreatic lesions.…”
Section: Current Approaches To Diagnosing Pancreatic Cancermentioning
confidence: 99%
“…Preoperative diagnosis of IPMN is currently based on radiologic studies, [ 8 ] pancreatic duct brushings/fine-needle aspiration (FNA) biopsy, [ 9 - 11 ] and carcinoembryonic antigen (CEA) level, which is usually elevated. More recently, molecular/genetic/genomic studies have become critical for the diagnosis.…”
Section: Introductionmentioning
confidence: 99%