Baclofen administration for the treatment of affective disorders in alcoholic patients

Krupitsky, Evgeny; Burakov, A.M.; Vl, Ivanov; Krandashova, G.F.; Lapin, I. P.; Grinenko, A. Ja; Borodkin, Yu. S.

doi:10.1016/0376-8716(93)90057-w

Cited by 84 publications

(54 citation statements)

References 16 publications

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“…Namely, it was found to be effective in reducing the severity of anxiety in patients affected by panic disorders [11], posttraumatic stress disorder [12] and alcohol use disorders (AUDs) [13], as well as the severity of binge eating in women affected by bulimia or binge eating disorder [14]. Conversely, it did not induce any effects in patients affected by schizophrenia [15,16].…”

Section: Pharmacological Features Of Baclofenmentioning

confidence: 99%

Efficacy and Tolerability of Baclofen in Substance Use Disorders: A Systematic Review

Agabio¹,

Preti

Gessa

2013

Eur Addict Res

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Background: It has been reported that baclofen, a drug used in the treatment of spasticity, reduces the severity of withdrawal symptoms and substance use disorders (SUDs) for some psychoactive drugs. Aims and Methods: To evaluate the effectiveness and safety of baclofen in the treatment of withdrawal syndrome and/or SUDs, providing (1) an outline of its pharmacological features; (2) a summary of studies that have suggested its possible effectiveness in the treatment of SUDs, and (3) a review of randomized, controlled trials (RCTs) on baclofen and SUDs. Results: Baclofen tolerability is generally considered to be good. Eleven RCTs investigated its effectiveness in the treatment of SUDs. Of these, 5 RCTs found that baclofen is effective, 5 RCTs found that it is ineffective and the results of 1 RCT were not appreciable because it did not achieve the preplanned level of participation. Conclusions: The number of RCTs on baclofen and SUDs is still low, and their results are divergent. Further RCTs should be undertaken, particularly with higher doses of baclofen. Its administration may be suggested in patients who fail to respond to other approved drugs or who are affected by liver disease that prevents their administration, or in patients affected by SUDs for which no approved drugs are available. Treatment should be conducted under strict medical supervision.

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Section: Pharmacological Features Of Baclofenmentioning

confidence: 99%

Efficacy and Tolerability of Baclofen in Substance Use Disorders: A Systematic Review

Agabio¹,

Preti

Gessa

2013

Eur Addict Res

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“…The effectiveness of drugs in these studies was evaluated using clinical psychological tests (Spielberger, Zung, MMPI) and electrophysiological tests (superslow ù-potentials). No side effects or complications were reported (26,32). BAC was also found to be effective in the treatment of affective manifestations of opiate and alcohol withdrawal syndromes (5).…”

Section: Clinical Studies With Pb and Bacmentioning

confidence: 99%

Phenibut (β‐Phenyl‐GABA): A Tranquilizer and Nootropic Drug

2001

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Phenibut (â-phenyl-ã-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA B and, to some extent, at GABA A receptors. It also stimulates dopamine receptors and antagonizes â-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre-or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.

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“…More specific ligands acting at GABA B receptors were studied later on. The efficacy of GABA B antagonist, baclofen, and GABA A agonist, diazepam, was shown to be equal to amitryptiline in the treatment of affective disturbances in alcoholic patients (Krupitsky et al, 1993). Other studies showed that baclofen worsens the symptoms of depression (Post et al, 1991).…”

Section: Gaba Receptors Ligands and Clinical Studiesmentioning

confidence: 98%