Baclofen and Clonazepam Overdose in a Patient with Chronic Neck and Shoulder Pain

Ehler, E; Meleková, Alena; Prax, Tomáš; ̌Sťetkářová, Ivana

doi:10.14735/amcsnn2017714

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Cited by 4 publications

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“…Serious side effects, such as GTCS and nonconvulsive status epilepticus, may occur, especially when ingested with a high overdose within a short period ( 1 ). Several patients showed comatose mental status, and GTCS reached beyond the therapeutic level by baclofen uptake in a short time ( 3 - 5 ). As approximately 15% of drugs are metabolized by the liver and 85% are excreted through the kidneys, patients with renal dysfunction may experience more toxic adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…Serious side effects such as generalized tonic-clonic seizures (GTCS) and nonconvulsive status epilepticus can also occur, especially when ingested with a high overdose within a short period ( 1 ). Several patients showed comatose mentality, and GTCS reached beyond the therapeutic level by baclofen uptake in a short time ( 3 - 5 ). We report two cases of patients with abruptly altered mentality accompanied by specific electroencephalography (EEG) changes who received low-dose baclofen for several months.…”

Section: Introductionmentioning

confidence: 99%

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