Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization

Srivastav, Saurabh; Fatima, Mahino; Mondal, Amal Chandra

doi:10.1016/j.neuint.2018.10.001

Cited by 33 publications

(27 citation statements)

References 55 publications

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“…B. monnieri improved behavioral abnormalities and reduced oxidative stress and apoptosis in this fly model of Parkinson's disease. Srivastav et al (2018), investigated the effects of a standardized extract of B. monnieri (solvent not specified; 1% concentration provided in the diet for 48 h) against paraquat-induced toxicity in a D. melanogaster model of Parkinson's disease. B. monnieri decreased acute paraquat-induced toxicity by optimizing redox balance and mitochondrial function, decreasing apoptosis, optimizing active c-Jun N-terminal kinase (JNK) protein and cleaved caspase-3 activity, and stabilizing the transcriptional regulation of genes that are responsible for regulating apoptosis and oxidative stress.…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 143mentioning

confidence: 99%

Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

Santos¹,

Souza²,

Pauli³

et al. 2022

BLACPMA

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Bacopa monnieri(L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and activity of B. monnieriin the central nervous system. It reviewed articles on B. monnieriusing Google Scholar, SciELO, Science Direct, Lilacs, Medline, and PubMed. Saponins are the main compounds in extracts of B. monnieri. Pharmacological studies showed that B. monnieriimproves learning and memory and presents biological effects against Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. No preclinical acute toxicity was reported. However, gastrointestinal side effects were reported in some healthy elderly individuals. Most studies with B. monnierihave been preclinical evaluations of cellular mechanisms in the central nervous system and further translational clinical research needs to be performed to evaluate the safety and efficacy of the plant.

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Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 143mentioning

confidence: 99%

Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

Santos¹,

Souza²,

Pauli³

et al. 2022

BLACPMA

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“…RT-PCR was performed according to a published protocol (Srivastav et al 2018), with minor modi cations. After injury induction at zero time point (0 days post injury (DPI)), the injured sh were euthanized at two different time points: 1DPI and 4DPI.…”

Section: Real Time Polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

Induction of oxidative stress and apoptosis in the injured brain: potential relevance to brain regeneration in zebrafish

2021

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In the recent years, zebra sh, owing to its tremendous adult neurogenic capacity, has emerged as a useful vertebrate model to study brain regeneration. Recent ndings suggest a signi cant role of the BDNF/TrkB signaling as a mediator of brain regeneration following a stab injury in the adult zebra sh brain. Since BDNF has been implicated in a plethora of physiological processes, we hypothesized that these processes are affected in the injured zebra sh brain. In this small study, we examined the indicators of oxidative stress and of apoptosis using biochemical assays, RT-PCR and IHC to re ect upon the impact of stab injury on oxidative stress levels and apoptosis in the injured adult zeba sh brain. Our results indicate induction of oxidative stress in the injured adult zebra sh brain. Also, apoptosis was induced in the injured brain as indicated by increased protein levels of cleaved caspase3 as well as enhanced mRNA levels of both proapoptotic and anti-apoptotic genes. This knowledge contributes to the overall understanding of adult neurogenesis in the zebra sh model and raises new questions pertaining to the compensatory physiological mechanisms in response to traumatic brain injury in the adult zebra sh brain.

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“…Similar to polyphenols, terpenes are classified into many categories based on the number of carbon atoms and iso-prene residues present in their structure, ranging from monoterpenes to polyterpenes [ 108 ]. As some triterpenes are steroidal in nature, they are known as triterpenoid saponins, among which bacosides/bacopasides and withanolides represent two major bioactive compounds of nootropic and neuroprotective plant extracts [ 3 , 71 , 109 , 110 , 111 , 112 , 113 ]. Within the tetraterpenoid group, carotenoids (such as α-/β carotene, lutein, zeaxanthin, and fucoxanthin) occurring widely in orange fruits and vegetables, are worth citing for their neuroprotective effects in various experimental models of neurodegeneration, especially AMD [ 7 , 114 , 115 ].…”

Section: An Overview Of Neuroprotective Phytochemical Classesmentioning

confidence: 99%

“…In the last decades, the search for an effective and potentially safe strategy to combat oxidative stress-mediated neuronal damage has increasingly prompted the investigation of naturally occurring compounds as antioxidant agents. The attenuation of oxidative stress by bioactive compounds belonging to different classes of phytochemicals including (i) flavonoids (quercetin, kaempferol and myricetin, scutellarin, baicalin, apigenin, catechins, epigallocatechin, and genistein) [ 52 , 61 , 81 , 82 , 83 , 88 , 94 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 ]; (ii) phenolic acids (syringic, gallic, caffeic, chlorogenic and salvianolic acids, and curcumin) [ 70 , 103 , 104 , 105 , 138 , 139 , 140 , 141 , 142 , 143 ]; (iii) flavonolignans (silymarin) [ 96 ]; (iv) stilbenes (resveratrol) [ 59 , 65 , 97 , 98 , 144 ]; (v) terpenes (bacosides/bacopasides, withanolides, and the carotenoids lutein and zeaxanthin) [ 7 , 110 , 113 , 115 , 145 , 146 , 147 ]; (vi) alkaloids (berberine and caffeine) [ 148 , 149 ]; (vii) glucosinolates (sulforaphane) and polyamines (spermine/spermidine) [ 123 , 124 ,…”

Section: Phytochemicals and Oxidative Stressmentioning

confidence: 99%

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

et al. 2020

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Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.

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Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization

Cited by 33 publications

References 55 publications

Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

Induction of oxidative stress and apoptosis in the injured brain: potential relevance to brain regeneration in zebrafish

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

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