Bacteraemia in outpatients with community-acquired pneumonia

Cillóniz, Catia; Gabarrús, Albert; Almirall, Jordi; Amaro, Rosanel; Rinaudo, Mariano; Travierso, Chiara; Niederman, Michael S.

doi:10.1183/13993003.01308-2015

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…An earlier study reported from Jimma, Ethiopia also had documented that respiratory tract is the primary site of infections 22 . These might be due to the fact that BSI are more common and possibly is the reflection of typical complications arising from community-acquired pneumonia 47 . The most prevalent co-morbid condition found in culture-positive patients was diabetes mellitus, 22.7%, and this resembles the results of some earlier studies done in Cambodia 30 and Côte d'Ivoire 40 .…”

Section: Discussionmentioning

confidence: 99%

Bacterial profile, antimicrobial susceptibility patterns, and associated factors among bloodstream infection suspected patients attending Arba Minch General Hospital, Ethiopia

Birru

Woldemariam

Manilal

et al. 2021

Sci Rep

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Bacterial bloodstream infections are of great concern globally. Of late, the emergence of drug resistant bacteria worsen the related morbidity and mortality. This study was aimed to determine the bacterial profile, antimicrobial susceptibility patterns, and associated factors among the blood stream infection (BSI) suspected patients attending the Arba Minch General Hospital (AMGH), southern Ethiopia, from 01 June through 31st August, 2020. A cross-sectional study was conducted among 225 BSI suspected patients. Systematic random sampling method was used to select patients. Blood culture was done to isolate bacterial pathogens. Antimicrobial susceptibility test was performed by employing the Kirby-Bauer disc diffusion method. Descriptive statistics and multivariable logistic regression analysis were done by Statistical Package for Social Service (SPSS) version 22. The rate of prevalence of bacteriologically confirmed cases was 22/225 (9.8%). Majority of BSI were caused by Gram-positive cocci, 13/22 (59.1%), particularly the isolates of S. aureus, 7/22 (31.8%) followed by Enterococci species, 4/22 (18.2%) and coagulase-negative Staphylococci (CoNS), 2/22 (9.1%). Among the Gram-negative bacteria 9/22 (41.1%), Klebsiella species 4/22 (18.2%) was the prominent one followed by Escherichia coli 2/22 (9.1%), Pseudomonas aeruginosa 2/22 (9.1%), and Enterobacter species 1/22 (4.5%). All the isolates of Gram-negative bacteria were susceptible to meropenem whereas 69.2% of the isolates of Gram-positive counterparts were susceptible to erythromycin. Slightly above two third (68.2%) of the total isolates were multidrug resistant. Insertion of a peripheral intravenous line was significantly associated with BSI [p = 0.03; Adjusted Odds Ratio = 4.82; (Confidence Interval: 1.08–21.46)]. Overall results revealed that eventhough the prevalence of BSI in Arba Minch is comparatively lower (9.8%), multidrug resistance is alarmingly on the rise, which is to be addressed through effective surveillance and control strategies.

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Section: Discussionmentioning

confidence: 99%

Bacterial profile, antimicrobial susceptibility patterns, and associated factors among bloodstream infection suspected patients attending Arba Minch General Hospital, Ethiopia

Birru

Woldemariam

Manilal

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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“…Patients who have acquired pneumococci in their bloodstream do not always develop sepsis and clinical 42 presentations vary from mild respiratory disease to imminent death. 11 Aside from the classical vulnerable 43 elderly patient who slowly recovers from pneumococcal pneumonia upon in-hospital treatment, IPD can 44 manifest at all ages, in a range of body sites, with varying severity and sequelae. It is important to 45 understand the origins of this diversity.…”

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confidence: 99%

The contribution of genetic variation ofStreptococcus pneumoniaeto the clinical manifestation of invasive pneumococcal disease

Cremers

Mobegi

Jongh

et al. 2017

Preprint

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“…112,113 Furthermore, blood cultures are positive for a pathogen in less than 20% of hospitalized CAP patients. [112][113][114][115][116][117][118][119][120] Invasive mechanical ventilation in patients with severe CAP facilitates the collection of lower respiratory tract samples, either by endotracheal aspirate, or bronchoalveolar lavage (BAL) or protected specimen brush. In contrast, nonmechanically ventilated CAP patients represent a more challenging group of patients, in whom collection of respiratory specimens are dependable of several factors that include the ability to cough, the evidence of productive sputum production, and the several clinical conditions of the patient.…”

Section: Diagnosismentioning

confidence: 99%

Emerging Resistance of Gram Negative Pathogens in Community-Acquired Pneumonia

Amati

Restrepo²

2020

Semin Respir Crit Care Med

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AbstractIn recent decades, there has been a growing interest about the role of gram negative bacteria in community-acquired pneumonia (CAP), especially Pseudomonas aeruginosa, Enterobacteriaceae, and Acinetobacter baumannii. The prevalence of these pathogens differs largely according to the local ecology and the geographical location. Identifying gram negative bacteria, and in particular resistant gram negative bacteria, is of paramount importance in patients with CAP because these pathogens are associated with higher clinical severity and unfavorable outcomes. The use of individualized risk factors to predict each pathogen is a helpful strategy that needs to be locally validated. However, it should be taken into account that most of the risk factors identified in the literature are heterogeneously defined or lack consistency. New diagnostic techniques, such as molecular testing, are promising methods for early detection of these gram negative pathogens. The increasing mechanisms of resistance to antibiotics of these pathogens have limited our therapeutic approach. This narrative review focuses on the epidemiology, risk factors, diagnosis, and therapeutic options for the most relevant gram negative bacteria that cause CAP.

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Bacteraemia in outpatients with community-acquired pneumonia

Cited by 7 publications

References 14 publications

Bacterial profile, antimicrobial susceptibility patterns, and associated factors among bloodstream infection suspected patients attending Arba Minch General Hospital, Ethiopia

Bacterial profile, antimicrobial susceptibility patterns, and associated factors among bloodstream infection suspected patients attending Arba Minch General Hospital, Ethiopia

The contribution of genetic variation ofStreptococcus pneumoniaeto the clinical manifestation of invasive pneumococcal disease

Emerging Resistance of Gram Negative Pathogens in Community-Acquired Pneumonia

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