Bacteremia and bacterascites after endoscopic sclerotherapy for bleeding esophageal varices and prevention by intravenous vefotaxime: A randomized trial

Selby, Warwick; Norton, Ian D.; Pokorny, Christopher S; Benn, Richard

doi:10.1016/s0016-5107(94)70109-1

Cited by 63 publications

(35 citation statements)

References 26 publications

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“…Another more recent meta-analysis that also included two small randomized trials of antibiotic prophylaxis immediately prior to sclerotherapy [58,59] supported the conclusions of the previous meta-analysis and advocated the use of short-term prophylaxis in this setting [60]. Additionally, antibiotic prophylaxis with ofloxacin in patients with variceal bleeding has been shown to be associated with a lower probability of early rebleeding compared to patients not on prophylaxis [7].…”

Section: Patients Hospitalized With Gastrointestinal Hemorrhagementioning

confidence: 84%

Bacterial infections in cirrhosis: treatment and prophylaxis

García–Tsao

2005

Journal of Hepatology

105

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Section: Patients Hospitalized With Gastrointestinal Hemorrhagementioning

confidence: 84%

Bacterial infections in cirrhosis: treatment and prophylaxis

García–Tsao

2005

Journal of Hepatology

105

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“…Several meta-analyses have demonstrated a reduction in bacterial infections and improved survival attributed to the use of short-term prophylactic antibiotics [50]. No consensus exists as to which antibiotic should be given but as the majority of studies used quinolones [51,52], these are generally recommended, for 5-7 days, intravenous initially and then orally. The procedure is performed under general anesthesia and thus an emergency consultation with anesthesia is initiated as soon as TIPS is considered.…”

Section: Pre-tips Work-upmentioning

confidence: 99%

Transjugular intrahepatic portosystemic shunt for acute variceal gastrointestinal bleeding: Indications, techniques and outcomes

Loffroy

Favelier

Pottecher

et al. 2015

Diagnostic and Interventional Imaging

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Acute variceal bleeding is a life-threatening condition that requires a multidisciplinary approach for effective therapy. The transjugular intrahepatic portosystemic shunt (TIPS) procedure is a minimally invasive image-guided intervention used for secondary prevention of bleeding and as salvage therapy in acute bleeding. Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy fail, before the clinical condition worsens. Furthermore, admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively. This procedure involves establishment of a direct pathway between the hepatic veins and the portal veins to decompress the portal venous hypertension that is the source of the patient's bleeding. The procedure is technically challenging, especially in critically ill patients, and has a mortality of 30%-50% in the emergency setting, but has an effectiveness greater than 90% in controlling bleeding from gastro-esophageal varices. This review focuses on the role of TIPS in the setting of variceal bleeding, with emphasis on current indications and techniques for TIPS creation, TIPS clinical outcomes, and the role of adjuvant embolization of varices.

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“…Plusieurs méta-analyses ont démontré une réduction des infections bactériennes et une amélioration de la survie attribuées à l'utilisation d'une antibiothérapie prophylactique à court terme [51]. Il n'existe aucun consensus concernant le type d'antibiotiques à administrer, mais dans la mesure où la majorité des études utilisent des quinolones [52,53], elles sont généralement recommandées, pendant 5 à 7 jours, par voie intraveineuse initialement puis par voie orale. La procé-dure est réalisée sous anesthésie générale et par conséquent une consultation d'urgence avec anesthésie est organisée dès qu'un SPIT est envisagé.…”

Section: Contre-indicationsunclassified