Bacteremia and Blood Culture Utilization During COVID-19 Surge in New York City

Sepulveda, Jorge L.; Westblade, Lars F.; Whittier, Susan; Satlin, Michael J.; Greendyke, William; Aaron, Justin G.; Zucker, Jason; Dietz, Donald; Sobieszczyk, Magdalena E.; Choi, Justin; Liu, Dakai; Espinal, Kelvin; Russell, Sarah M.; Camp, D. W.; Connelly, Charles; Green, Daniel A.

doi:10.1101/2020.05.05.20080044

Cited by 42 publications

(62 citation statements)

References 10 publications

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“…We observed a higher rate (33.5%) of positive blood cultures than reported in the literature (3.8% to 12%) [9,10] and by the same ICUs last year (12.8%, personal data). More than half of these were considered as contaminants that may be due to changes in guidelines and safety equipment of nursing staff due to the COVID-19 crisis.…”

Section: Discussioncontrasting

confidence: 42%

Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France

d’Humières

Patrier

Lortat‐Jacob

et al. 2021

Preprint

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Section: Discussioncontrasting

confidence: 42%

Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France

d’Humières

Patrier

Lortat‐Jacob

et al. 2021

Preprint

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“…Additionally, more BCs are likely to be taken in patients with COVID-19 due to its febrile nature. This has been substantiated by Sepulveda et al (21) who found a surge in BCs during March 2020, the majority of which were for SARS-CoV-2 positive patients, including repeated sampling. They found that CoNS accounted for 59.7% of positive BCs in these patients.…”

Section: Discussionmentioning

confidence: 66%

Bacteraemia Variation During The COVID-19 Pandemic; A Multi-Centre UK Secondary Care Ecological Analysis.

Denny

Rawson

Satta

et al. 2020

Preprint

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Objectives – We investigated for change in blood stream infections (BSI) with Enterobacterales, coagulase negative staphylococci (CoNS), Streptococcus pneumoniae, and Staphylococcus aureus during the first UK wave of SARS-CoV-2 across six London hospitals.Methods – A retrospective multicentre ecological analysis was undertaken evaluating all blood cultures taken from adults from 01 April 2017 to 30 April 2020 across six acute hospitals in London. Linear trend analysis and ARIMA models allowing for seasonality were used to look for significant variation.Results –119,584 blood cultures were included. At the height of the UK SARS-CoV-2 first wave in April 2020, Enterobacterales bacteraemias were at an historic low across two London trusts (63/3814, 1.65%), whilst CoNS were at an historic high (173/3814, 4.25%). This differed significantly for both Enterobacterales (p=0.013) and CoNS (p<0.01), when compared with prior periods, even allowing for seasonal variation. S. pneumoniae (p=0.631) and S. aureus (p=0.617) BSI did not vary significant throughout the study period.Conclusions – Significantly fewer than expected Enterobacteriales BSI occurred during the UK peak of the COVID-19 pandemic; identifying potential causes, including potential unintended consequences of national self-isolation public health messaging, is essential. High rates of CoNS BSI, presumably representing contamination associated with increased use of personal protective equipment, may result in inappropriate antimicrobial use and indicates a clear area for intervention during further waves.

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“…Also, the animal models of the mixed sepsis have been established successfully [76]. Furthermore, during the COVID-19 outbreak, the cases with mixed sepsis were also more frequently reported [77][78][79][80].…”

Section: Sepsis Is Related To Severe Covid-19-associated Abdmentioning

confidence: 99%

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

2021

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In global term, as of November 30, 2020, over 30 million people has been infected by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10,000,000 of them died of acute organ failure. Our reviews have shown that coronavirus disease 2019 (COVID-19) patients with pneumonia and acute respiratory distress syndrome (ARDS) have life-threatening acute brain dysfunction (ABD), ranging from altered mental status/delirium to stupor/coma. Altered mental status/delirium was the most common manifestation of ABD caused by severe COVID-19. The prevalence of altered mental status and/or delirium was up to 66-79.5%, and prevalence of coma was 10%. The most common clinical type of COVID-19-associated ABD was COVID-19-associated acute stroke including ischemic and hemorrhagic stroke (n > 350 cases), followed by COVID-19-associated encephalopathy (n > 200 cases), and COVID-19-associated central nervous system (CNS) infection (n > 70 cases). According to the Sepsis-3 criteria, we confess that severe COVID-19-associated ABD with ARDS and altered mental status is related to sepsis. Moreover, we also review the diagnosis and treatment of COVID-19-associated ABD with sepsis. In view of the fact that COVID-19 is at the peak of epidemic worldwide, we hope that this review will provide evidence of COVID-19 sepsis threating to the brain dysunction. Thus, recognizing the COVID-19-associated ABD related to sepsis is very important for early empirical combination therapy to survive severe COVID-19.

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Bacteremia and Blood Culture Utilization During COVID-19 Surge in New York City

Abstract: 2 7

Cited by 42 publications

References 10 publications

Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France

Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France

Bacteraemia Variation During The COVID-19 Pandemic; A Multi-Centre UK Secondary Care Ecological Analysis.

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

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