Bacteremia caused by an Acinetobacter junii strain harboring class 1 integron and diverse DNA mobile elements

Traglia, Germán Matías; Almuzara, Marisa; Vilacoba, Elisabet; Tuduri, Alicia; Neumann, Gabriela; Pallone, E; Centrón, Daniela; Ramírez, María Soledad

doi:10.3855/jidc.3747

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…Um dos perfis de risco associado ao A. baumanni é o uso de antibióticos de amplo espectro, tornando dificultoso o tratamento bacteriano devido à resistência desenvolvida por esse microrganismo. As bactérias Gram-negativas apresentam estruturas diferenciadas das Gram-positivas, determinando qual tipo de resistência vai iniciar 25 .…”

Section: Resistência Antimicrobianaunclassified

Avaliação Dos Fatores Associados a Infecções Por Acinetobacter Baumannii Em Pacientes Imunodeprimidos Em Unidade De Terapia Intensiva

Pessoa¹

2022

RECIMA21

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Devido à crescente relevância das infecções hospitalares em UTI torna-se fundamental o conhecimento epidemiológico, seu mecanismo de resistência e as manifestações clínicas associado ao Acinetobacter baumannii. Este microrganismo é a bactéria mais recorrente nas infecções em UTI acometendo pacientes imunodeprimidos, apresentando um grave problema de saúde pública por vários casos de infecção hospitalar. O objetivo deste estudo foi analisar fatores associados às frequentes infecções bacterianas por Acinetobacter baumannii em pacientes internados nas unidades de terapia intensiva. Esta revisão bibliográfica foi realizada a partir de quatro bases de dados: Medline, Lilacs, Decs e SciELO, considerando-se artigos publicados no período de 2008 a 2015, nos idiomas português, inglês e espanhol. “Foram pesquisadas as palavras-chaves “infecção hospitalar”, ‘‘Acinetobacter” e "Acinetobacter baumannii". As infecções por Acinetobacter baumannii adquirida pelos pacientes internados em unidade de terapia intensiva é essencial à detecção precoce deste patógeno, de modo a adotar medidas preventivas para minimizar a disseminação bacteriana e evitar a contaminação cruzada entre os profissionais da saúde, os quais são a sua principal rota de contaminação. A incorreta intervenção determina a presença deste microrganismo no âmbito hospitalar. A infecção nosocomial pelo Acinetobacter baumannii está associada à predisposição do individuo e a submissão deste a procedimentos invasivos. Para o controle da infecção o antimicrobiano de escolha deve ser avaliado de duas formas: a resistência bacteriana na unidade hospitalar e o fármaco de escolha deve apresentar atividade intrínseca compatível com os carbapenêmicos.

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Section: Resistência Antimicrobianaunclassified

Avaliação Dos Fatores Associados a Infecções Por Acinetobacter Baumannii Em Pacientes Imunodeprimidos Em Unidade De Terapia Intensiva

Pessoa¹

2022

RECIMA21

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“…Affected individuals have multimorbidities and are usually hospitalized in the intensive care unit ( 1 , 2 ). Some other representatives of the genus, like Acinetobacter junii , are only sporadically associated with human infections ( 3 , 4 ). Recently, nosocomial infections produced by Acinetobacter spp.…”

Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of Acinetobacter junii Strain INC8271, Isolated from a Patient with Metastatic Cancer and Bacteremia

Escobedo-Muñoz

Bello-López

Velázquez-Acosta

et al. 2021

Microbiol Resour Announc

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“…The potency of new identification technologies including DNA sequencing, Multilocus sequence typing (MLST) and Matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry (MALDI‐TOF MS) allows nowadays to achieve an accurate identification of microorganisms responsible of nosocomial infections . This has revealed that many species other than A. baumannii within the Acinetobacter genus can also cause nosocomial infections, being of particular relevance A. nosocomialis and A. pittii, other members of the A. baumannii ‐ calcoaceticus complex , as well as A. junii, A. lwoffii, A. ursingii and A. johnsonii .…”

Section: Light Sensing Is Distributed Within the Genus Acinetobactermentioning

confidence: 99%

More Than Just Light: Clinical Relevance of Light Perception in the Nosocomial Pathogen Acinetobacter baumannii and Other Members of the Genus Acinetobacter

Ramírez

Müller

Pérez

et al. 2015

Photochem & Photobiology

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A summary of the major findings concerning light modulation in Acinetobacter baumannii, which governs aspects related to the success of this microorganism as a nosocomial pathogen, is presented. Particularly, the evidence shows that light modulates the ability of the bacteria to persist in the environment, its virulence against eukaryotic hosts and even susceptibility to certain antibiotics. The light signal is sensed through different mechanisms, in some cases involving specialized photoreceptors of the BLUF-type, whereas in others, directly by a photosensitizer molecule. We also provide new data concerning the genomic context of BLUF-domain containing proteins within the genus Acinetobacter, as well as further insights into the mechanism of light-mediated reduction in susceptibility to antibiotics. The overall information points toward light being a crucial stimulus in the lifestyle of members of the genus Acinetobacter as well as in other clinically relevant species, such as members of the ESKAPE group, playing therefore an important role in the clinical settings. INTRODUCTIONOur planet is one of the few places in universe close enough to one star that its whole surface bathes in light, and where life can take place. Each human cell and most forms of life on Earth synchronize their activities taking into account this ubiquitous environmental signal.In addition to incident solar radiation, humans and other organisms are exposed to artificial and man-made electromagnetic radiation used for indoor and outdoor lighting, medical diagnosis and treatment of diseases (1).However, the effects light produces on living organisms are far from being completely understood. In the case of bacteria, extensive knowledge has been accumulated for phototrophs, which capture light to convert it into chemical bond energy or electrochemical potential for processes dedicated to satisfy cellular energy requirements (2,3). However, information recalled during the last decades indicates that this signal also plays a role in the physiology of environmental and pathogenic chemotrophic nonphototrophic prokaryotes (3-5). Pertinent examples include physiological responses as diverse and interesting as morphogenesis in Stigmatella aurantiaca (6); carotenogenesis in Streptomyces coelicolor (7) and Myxococcus xanthus (8,9); the general response to stress in Bacillus subtilis (10,11); the attachment of Caulobacter crescentus to glass surfaces (12); the photophobic response and various biofilm functions in Escherichia coli (13,14); biofilm formation in Idiomarina loihiensis (15); motility in Acinetobacter calcoaceticus and other Acinetobacter species (16)(17)(18)(19)(20). Light signals perceived by nonphotosynthetic bacteria may even modulate their interactions with hosts (5,21). For instance, light regulates the general stress response and infection of macrophages by Brucella abortus (22,23), the virulence of Agrobacterium tumefaciens toward cucumber (24); the invasiveness of Listeria monocytogenes for enterocytes (25); the nodulation o...

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Bacteremia caused by an Acinetobacter junii strain harboring class 1 integron and diverse DNA mobile elements

Cited by 8 publications

References 24 publications

Avaliação Dos Fatores Associados a Infecções Por Acinetobacter Baumannii Em Pacientes Imunodeprimidos Em Unidade De Terapia Intensiva

Avaliação Dos Fatores Associados a Infecções Por Acinetobacter Baumannii Em Pacientes Imunodeprimidos Em Unidade De Terapia Intensiva

Complete Genome Sequence of Acinetobacter junii Strain INC8271, Isolated from a Patient with Metastatic Cancer and Bacteremia

More Than Just Light: Clinical Relevance of Light Perception in the Nosocomial Pathogen Acinetobacter baumannii and Other Members of the Genus Acinetobacter

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