Bacteremia caused by Comamonas testosteroni an unusual pathogen

Tiwari, Shreekant; Nanda, Monalisah

doi:10.4103/jlp.jlp_116_18

Cited by 28 publications

(24 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recreational hot springs are known to harbor pathogens associated with human diseases such as Clostridium and Legionella strains (Chan et al 2015, Ghilamicael et al 2018. Our results suggested the occurrence of opportunistic pathogens causing bacteremia or the presence of bacteria in the human blood, such as Comamonas testosteroni (3.70%), Comamonas aquatica (3.54%), and Vogesella perlucida (0.59%) (Farooq et al 2017, Farshad et al 2012, Kaeuffer et al 2018, Tartar and Tartar 2020, Tiwari and Nanda 2019, Yu et al 2020. Furthermore, genus Blautia (3.21%) and Ruminococcus (2.86%), which are related to fecal contamination, were also observed (Devane et al 2020, Koskey et al 2014, Staley et al 2016).…”

Section: Discussionmentioning

confidence: 66%

Unraveling the bacterial diversity of Cangar Hot Spring, Indonesia by Next Generation Sequencing of 16S rRNA gene

et al. 2021

View full text Add to dashboard Cite

Abstract. Geraldi A, Tay CC, Ni’matuzahroh, Fatimah, Hanafi WNW. 2021. Unraveling the bacterial diversity of Cangar Hot Spring, Indonesia by Next Generation Sequencing of 16S rRNA gene. Biodiversitas 22: 4060-4066. This study is the first attempt at using the Next Generation Sequencing (NGS) method with 16S rRNA to understand the bacterial community structure in an Indonesian hot spring. This study aims to unravel the bacterial diversity of the Cangar Hot Spring as one of the most explored natural hot springs in East Java, Indonesia. We found Proteobacteria and Bacteroidetes as the two most abundant phyla. We discovered the first occurrence of genera Cloacibacterium and Methylobacillus in the hot spring ecosystem, which was the most dominant genera at Cangar Hot Spring. We also found several potential bacteria for bioindustry and bioremediation, such as Acinetobacter junii and Pseudomonas alcaligenes. Besides that, we also observed opportunistic pathogens from genera Comamonas and Vogesella. This study result will provide valuable information for further bioprospecting of bacteria with commercial potential and the development of health and safety measures in the Cangar Hot Spring, among others. Hopefully, this report would encourage the use of NGS technology for studying other hot springs in Indonesia.

show abstract

Section: Discussionmentioning

confidence: 66%

Unraveling the bacterial diversity of Cangar Hot Spring, Indonesia by Next Generation Sequencing of 16S rRNA gene

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Comamonas species are infrequently reported as an infectious agent in routine clinical practice due to rare isolates in microbiology laboratories. In recent years, Comamonas kerstersii and Comamonas testosteroni were identified to cause appendicitis and bacteremia by microbiome sequencing ( 30 , 31 ). Subclinical gut inflammation is common in AS patients, but its relationship with Comamonas needs further study.…”

Section: Discussionmentioning

confidence: 99%

Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis

Chen

Zheng

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Growing evidence suggests that the gut microbiota is involved in the initiation and progression of ankylosing spondylitis (AS). In this study, we aimed to explore the gut microbiome alterations during adalimumab therapy and verify microbiome biomarkers predicting treatment response. By evaluating the gut microbial features of 30 AS patients before and after adalimumab therapy for 6 months and 24 healthy controls, we confirmed that the microbiome was restored remarkably after 6 months of adalimumab therapy in AS patients. We then compared the baseline gut microbiome of 22 adalimumab responders with 8 non-responders, a higher abundance of Comamonas was revealed in the latter, although no statistical difference was found after adjusting for the false discovery rate. These results suggested that adalimumab therapy restored the gut microbiome in AS patients and indicated the utility of gut microbiome to be potential biomarkers for therapeutic evaluation. These findings provided an insight into the development of predictive tools and the establishment of precise medical interventions for clinical practice.

show abstract

“…The bioinformatic analyses presented in this paper based on extensive available metagenomic data sets suggest that ACBP/DBI-producing bacterial species are rather rare in the human microbiome and are mostly produced by eukaryotic species (as exemplified by the yeast S. cerevisiae ) and environmental or potentially pathogenic bacteria (exemplified by Comamonas kerstersii that can cause peritonitis, bacteremia, and sepsis [ 41 – 43 ]), as well as potential sample contaminants. Indeed, the presence of ACBP/DBI-producing species in the human gut appears relatively rare.…”

Section: Discussionmentioning

confidence: 99%

Genes Encoding Microbial Acyl Coenzyme A Binding Protein/Diazepam-Binding Inhibitor Orthologs Are Rare in the Human Gut Microbiome and Show No Links to Obesity

Thomas

Asnicar

Kroemer

et al. 2021

Appl Environ Microbiol

View full text Add to dashboard Cite

Acyl coenzyme A (CoA) binding protein (ACBP), also called diazepam-binding inhibitor (DBI) is a phylogenetically conserved protein that is expressed by all eukaryotic species as well as by some bacteria. Since elevated ACBP/DBI levels play a major role in the inhibition of autophagy, increase in appetite and lipoanabolism that accompany obesity, we wondered whether ACBP/DBI produced by the human microbiome might affect host weight. We found that the genomes of bacterial commensals rarely contain ACBP/DBI homologues, which are rather encoded by genomes of some pathogenic or environmental taxa that were not prevalent in human feces. Exhaustive bioinformatic analyses of 1,899 gut samples from healthy individuals refuted the hypothesis that bacterial ACBP/DBI might affect the BMI in a physiological context. Thus, the physiological regulation of BMI is unlikely to be affected by microbial ACBP/DBI-like proteins. However, at the speculative level, it remains possible that ACBP/DBI produced by potential pathogenic bacteria might enhance their virulence by inhibiting autophagy and hence subverting innate immune responses. Importance Acyl coenzyme A (CoA) binding protein (ACBP) can be encoded by several organisms across the domains of life, including microbes, and has shown to play major roles in human metabolic processes. However, little is known about its presence in the human gut microbiome and whether its microbial counterpart could also play a role in human metabolism. In the present study, we found that microbial ACBP/DBI sequences were rarely present in the gut microbiome across multiple metagenomic datasets. Microbes that carried ACBP/DBI in the human gut microbiome included Saccharomyces cerevisiae, Lautropia mirabilis and Comamonas kerstersii, but these microorganisms were not associated with body-mass index, further indicating an unconvincing role for microbial ACBP/DBI in human metabolism.

show abstract

Bacteremia caused by Comamonas testosteroni an unusual pathogen

Cited by 28 publications

References 10 publications

Unraveling the bacterial diversity of Cangar Hot Spring, Indonesia by Next Generation Sequencing of 16S rRNA gene

Unraveling the bacterial diversity of Cangar Hot Spring, Indonesia by Next Generation Sequencing of 16S rRNA gene

Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis

Genes Encoding Microbial Acyl Coenzyme A Binding Protein/Diazepam-Binding Inhibitor Orthologs Are Rare in the Human Gut Microbiome and Show No Links to Obesity

Contact Info

Product

Resources

About