Bacteremia caused by <i>Achromobacter</i> and <i>Alcaligenes</i> species in 46 patients with cancer (1989–2003)

Aisenberg, Gabriel M; Rolston, Kenneth V. I.; Safdar, Amar

doi:10.1002/cncr.20604

Cited by 172 publications

(181 citation statements)

References 23 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

Section: Discussionsupporting

confidence: 88%

“…Mortality was related to A. xylosoxidans infection in nine (22%) patients, which is similar to previous findings [20,21]. Aisenberg et al collaborators [20] revealed that sepsis syndrome and high APACHE II scores are predictors of an increase in 30-day mortality. Although the APACHE II score in the imipenem-resistant group (26.95 ± 8.02) was higher than that in the imipenem-nonresistant group (20.52 ± 6.06) (p < 0.05), there were no obvious differences in mortality (6 cases versus 3 cases).…”

Section: Discussionsupporting

confidence: 88%

“…Compared with a previous study, the APACHE II score (23.66 ± 7.71) was higher in the present analysis, which was mainly a result of old age [20]. Mortality was related to A. xylosoxidans infection in nine (22%) patients, which is similar to previous findings [20,21].…”

Section: Discussionsupporting

confidence: 76%

“…Treatment is also a challenge because of the high rate of antibiotic resistance among the elderly. Some researchers recommend trimethoprim-sulfamethoxazole, carbapenems, and antipseudomonal penicillins (with or without an aminoglycoside) for the treatment of systemic infections [20]. However, half of our patients were resistant to carbapenems.…”

Section: Discussionmentioning

confidence: 72%

See 3 more Smart Citations

Hospital-acquired pneumonia due to Achromobacter xylosoxidans in the elderly: A single-center retrospective study in Beijing

Liu

Guo

Yan

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

are co-first authors for this study. AbstractIntroduction: Achromobacter xylosoxidans has been reported in several countries; however, hospital-acquired pneumonia (HAP) due to this organism in elderly patients in China remains rare. Methodology: HAP due to Achromobacter xylosoxidans identified at the General Hospital of the People's Liberation Army in Beijing from January 2008 to October 2011 was studied. Detailed clinical manifestations were collected. To study the clinical risk factors for the imipenemresistant strain, patients were divided into two groups: imipenem-resistant (21 cases) and imipenem-nonresistant (20 cases). Univariate and multivariate logistic regression were used. Results: All patients were > 75 years of age, and 92.7% (38/41) were male. Nine patients died 30 days after infection. The mean acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) were 23.66 ± 7.71 and 6.93 ± 2.47, respectively. Almost all strains were resistant to aminoglycosides. However, the strains showed significant sensitivity to minocycline (MIN), piperacillin-tazobactam (PTZ), and cefoperazone-sulbactam (SCF). Compared with the imipenem-nonresistant group, more patients with imipenem-resistant infection had the following characteristics: use of an intubation, use of a proton-pump inhibitor (PPI), chronic obstructive pulmonary disease (COPD), and coronary artery disease (CHD). Among the four risk factors, COPD and CHD remained independent risk factors in the multivariate analysis. Conclusions: HAP due to Achromobacter xylosoxidans occurred in severely ill elderly patients with a long-term indwelling catheter and many underlying diseases. Effective treatment of imipenem-resistant organisms is challenging. SCF, PTZ, and MIN may be useful for imipenemresistant Achromobacter xylosoxidans.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 72%

See 2 more Smart Citations

Hospital-acquired pneumonia due to Achromobacter xylosoxidans in the elderly: A single-center retrospective study in Beijing

Liu

Guo

Yan

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…It was described in 1971 by Yabuuchi and Ohyama [1], who isolated it from purulent ear discharges from 7 patients with chronic otitis media. A.xylosoxidans has been isolated from a variety of human clinical sources, including blood, cerebrospinal fluid (CSF), sputum, peritoneal fluid, skin, ear discharge, wounds, abscesses, bone, joints, endocardium and central venous catheters [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Postoperative meningitis due to a rare pathogen; Alcaligenes xylosoxidans

et al. 2009

View full text Add to dashboard Cite

AbstractAlcaligenes xylosoxidans is non-fermenting gram-negative bacilli found in soil and water. It is an aerobic bacterium in the genus Achromobacter. This bacterium is motile, oxidase positive, and catalase positive, which is isolated uncommonly from clinical specimens. In the present paper, we report a case of meningitis associated with A. xylosoxidans in a 38-year-old male patient post neurosurgery.

show abstract

Gram‐negative rods

2015

Practical Medical Microbiology for Clinicians

View full text Add to dashboard Cite

Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989–2003)

Abstract: ) for providing the microbiologic information presented in the current report.

Cited by 172 publications

References 23 publications

Hospital-acquired pneumonia due to Achromobacter xylosoxidans in the elderly: A single-center retrospective study in Beijing

Hospital-acquired pneumonia due to Achromobacter xylosoxidans in the elderly: A single-center retrospective study in Beijing

Postoperative meningitis due to a rare pathogen; Alcaligenes xylosoxidans

Gram‐negative rods

Contact Info

Product

Resources

About