Bacteremia due to Chryseobacterium indologenes, a naturally carbapenem-resistant Gram-negative pathogen, in a geriatric patient

Degandt, Simon; Hoecke, Frederik Van; Colaert, J; D’Souza, Roshan; Pattyn, Inge; Boudewijns, Michaël

doi:10.1016/j.eurger.2013.06.003

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…C. indologenes is a rare pathogen known to cause different types of infections including bacteremia, meningitis, pneumonia, and indwelling device-associated infections [ 2 ]. Risk factors associated with C. indologenes infection includes older age, immunocompromised clinical status including diabetes or systemic steroid treatment, and history of indwelling catheter [ 6 – 10 ], which correlate with our patient with diabetes and chronic steroid treatment for adrenal insufficiency.…”

Section: Discussionmentioning

confidence: 90%

Chryseobacterium indologenes Keratitis: Successful Treatment of Multidrug-Resistant Strain

Lee

Mauger

2021

Case Reports in Ophthalmological Medicine

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A 72-year-old male with history of monocular vision with complete vision loss in his right eye from previous retinal detachment presented with 20/200 vision in the left eye with a corneal ulcer. Culture was obtained, and the patient was started on fortified tobramycin, fortified vancomycin, and amphotericin. Despite the antibiotics, the patient did not significantly improve, after which another culture was obtained before the patient was taken to the surgery for cryotherapy and a partial conjunctival flap. The culture identified Chryseobacterium indologenes. There have been fewer than a handful of cases reported in the last three decades with different antibiotic susceptibility profiles. Our patient was successfully treated with ciprofloxacin and ceftazidime with the final vision of 20/40.

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Section: Discussionmentioning

confidence: 90%

Chryseobacterium indologenes Keratitis: Successful Treatment of Multidrug-Resistant Strain

Lee

Mauger

2021

Case Reports in Ophthalmological Medicine

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“…In addition to device-related risk in the elderly, other predisposing factors include immunocompromising conditions such as diabetes and long-term treatment with systemic steroids. Infections such as healthcare-associated pneumonia in an immunocompetent patient and polymicrobial urinary tract infections have been reported in this age group 20 21 24. Outcomes of the hospitalised elderly have been favourable.…”

Section: Discussionmentioning

confidence: 98%

“…More than half of the reported cases have been among hospitalised, immunocompromised patients with mechanical ventilation or indwelling catheters 5 7 10 15. Although C. indologenes infections are nosocomial, device-related infections and, recently, non-catheter-related community-acquired C. indologenes bacteraemia in immunocompetent patients, have been reported 12 19 20…”

Section: Discussionmentioning

confidence: 99%

Chryseobacterium indologenes: an emerging infection in the USA

et al. 2016

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Nursing home-associated infections and antibiotic resistant pathogens constitute common and serious problems in the geriatric population.Chryseobacterium indologenes, a non-motile Gram-negative rod, though widely distributed in nature, is an uncommon human pathogen. Typically thought of as an organism of low virulence, it may cause serious infections, particularly among the immunocompromised. The majority of reported cases are nosocomial, often associated with immunosuppression or indwelling catheters. It has been reported as the causative agent in bacteraemia, peritonitis, pneumonia, empyema, pyelonephritis, cystitis, meningitis and central venous catheter-associated infections. We report a rare case of C. indologenesinfection affecting a nursing home resident in the USA and we provide a review of similar cases. This report emphasises the importance of individualised treatment and promotes awareness about this organism as one of several emerging pathogens in immunocompromised adults and in the frail elderly who are often nursing home residents, in the Western Hemisphere.

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“…are multidrug-resistant bacterial species which are known to cause hospital-acquired infections in immunocompromised patients. However, the immunocompetent population can also be infected by C. indologenes, thus these organisms are not only problematic in hospital settings but also in the community environment (Calderon et al, 2011;Degandt et al, 2013; Hsieh, Yang, Liu, & Lin, 2020). Additionally, C. indologenes is frequently isolated from cystic brosis patients with other opportunistic pathogens including Pseudomonas aeruginosa and Burkholderia cepacia (Lambiase et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Adding to the family of resistance factors against last resort antibiotics: Identification and characterization of a novel carbapenemase, CIM-1

Wang,

Sapula,

Whittall

et al. 2023

Preprint

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The increasing rate of carbapenem-resistant bacteria within healthcare environments is an issue of great concern that needs urgent attention. This resistance is driven by metallo-β-lactamases (MBLs), which can catalyse the hydrolysis of almost all clinically available β-lactams and are resistant to all the available β-lactamase inhibitors. In this study, a novel MBL was identified in a multidrug resistant isolate of the opportunistic pathogen, Chryseobacterium indologenes. Sequence analysis predicted this MBL (CIM-1) to be a lipoprotein with an atypical lipobox. Characterization of CIM-1 revealed it to be a membrane-associated, high-affinity carbapenemase with a broad spectrum of activity that includes all cephalosporins and carbapenems. This is the first report of the identification and characterisation of an MBL with an atypical lipobox and only the second lipidated MBL to be characterised after critically important NDM-1. We also identified more lipidated MBLs with non-canonical lipoboxes highlighting the necessity in further investigation of lipidated MBLs.

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Bacteremia due to Chryseobacterium indologenes, a naturally carbapenem-resistant Gram-negative pathogen, in a geriatric patient

Cited by 4 publications

References 8 publications

Chryseobacterium indologenes Keratitis: Successful Treatment of Multidrug-Resistant Strain

Chryseobacterium indologenes Keratitis: Successful Treatment of Multidrug-Resistant Strain

Chryseobacterium indologenes: an emerging infection in the USA

Adding to the family of resistance factors against last resort antibiotics: Identification and characterization of a novel carbapenemase, CIM-1

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