Bacteremia Due to Staphylococcus epldermidis: Microbiologic, Epidemiologic, Clinical, and Prognostic Features

Fidalgo, S.; Vázquez, Fernando; Mendoza, M. C.; Perez, Francisco A.; Méndez, Francisco Javier

doi:10.1093/clinids/12.3.520

Cited by 110 publications

(59 citation statements)

References 41 publications

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“…This study showed that S. epidermidis was the most common CoNS species comprising 43% of all isolates similar to that of other reports [11][12][13][14][15][16] . CoNS was reported as an important cause of blood stream infections and the second most common source after wound swabs in a hospital in Lebanon and Kuwait [17][18] .…”

Section: Discussionsupporting

confidence: 91%

Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Begum¹,

Anbumani²,

Kalyani³

et al. 2011

IJMEDPH

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Section: Discussionsupporting

confidence: 91%

Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Begum¹,

Anbumani²,

Kalyani³

et al. 2011

IJMEDPH

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“…9,10,14,17,22,24,36 The percentage of blood cultures positive for CNS and representing true bacteremia was very constant and similar both in time and numbers between the United States and Europe (mean, 18%; range, 6%-31%). 7,9,14,17,22,36,37…”

Section: Resultsmentioning

confidence: 95%

Increasing Bacteremia Due to Coagulase-Negative Staphylococci: Fiction or Reality?

Thylefors¹,

Harbarth²,

Pittet³

1998

Infect. Control Hosp. Epidemiol.

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BACKGROUND:The role of coagulase-negative staphylococci (CNS) in bacteremias continues to be controversial. Until the 1970s, CNS were mostly recognized as contaminants, being part of the cutaneous flora. Since then, several studies have reported increasing incidence and severity of infections due to CNS.PURPOSE:To review the literature concerning the epidemiology of CNS bacteremia in the United States and Europe with reference to the multiple definitions of infection versus contamination, considering the effect of potential biases influencing the validity of the reported results.METHODS:Literature search of the MEDLINE database from January 1980 to February 1998. Studies with fewer than 500 episodes of bloodstream infections or fewer than 100 episodes of CNS bacteremia were not included in the pooled analysis.RESULTS:(1) CNS remain the most frequent contaminants (58%-83% of positive blood cultures); (2) the proportion of all bloodstream infections caused by CNS is increasing (R=.51); (3) the overall incidence of true CNS bacteremia is increasing (R=.54, P=.0014); (4) comparing the United States to Europe, there is an increasing trend in the incidence of nosocomial bacteremia due to CNS in the United States (R=.82, P=.0006), but no trend is seen in European studies; (5) the mortality associated with true CNS bacteremia varies between 4.9% and 28%.DISCUSSION:This review confirms the increasing importance of CNS bacteremias, measured both as a proportion and as an incidence of bloodstream infections. The contributions of several possible explanations for the incidence increase and the difference between the United States and Europe need further evaluation: (1) increased recognition and awareness of CNS infections among clinicians; (2) a gradual change in the definition of true bacteremia from an obligatory two positive blood cultures to one positive blood culture associated with a clinical picture compatible with infection; (3) a change in blood culture practices and techniques; (4) an increase in the numbers of blood cultures performed, which is reported both in the United States and in Europe; (5) a shift toward more elderly patients with increasingly severe underlying illnesses; and (6) increasing use of intravascular devices.CONCLUSIONS:The apparent trend of increasing CNS bacteremia seems to be valid. Whether there is a real difference between the United States and Europe concerning the increase of CNS bacteremia is difficult to establish due to the large number of confounding factors. Few studies take into account the number of blood cultures performed or the use of intravascular devices to adjust for the observed trends. Further on-site surveillance studies are needed to investigate the phenomenon more extensively.

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“…Fidalgo ve arkadaşları ise S. epidermidis'e bağlı KDİ'leri inceledikleri çalışmalarında mortalite oranının %36.9 olduğunu, tek değişkenli analizde eşlik eden hastalık, hemodinamik durumun bozuk olması, nötropeni, kanser, cerrahi geçirme, travma, bağışıklığı baskılayıcı tedavi, daha önce antibiyotik tedavisi ve total parenteral beslenme gibi kolaylaştırıcı faktörler ve ampirik tedavinin uygun olmamasını mortalite açısından anlamlı bulmuşlardır [19] . Park ve arkadaşları KNS bakteremisi ilişkili 30 gün mortalite oranının %14 olduğunu bildirmişlerdir [20] .…”

Section: İstatistiksel Analizunclassified

“…KNS infeksiyonlarının tedavisinde metisilin direnci, tedavi seçeneklerinin kısıtlılığına yol aç-maktadır [14][15][16][17][18][19][20] . Çalışmamızda KDİ etkenlerinin %77.8'i metisiline dirençli bulunmuştur.…”

Section: İstatistiksel Analizunclassified

Is There Clinical Significance to Coagulase-Negative Staphylococci Isolated from Blood Cultures?

Çalık¹,

Tosun²,

Altin³

et al. 2017

FLORA

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Bacteremia Due to Staphylococcus epldermidis: Microbiologic, Epidemiologic, Clinical, and Prognostic Features

Cited by 110 publications

References 41 publications

Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Increasing Bacteremia Due to Coagulase-Negative Staphylococci: Fiction or Reality?

Is There Clinical Significance to Coagulase-Negative Staphylococci Isolated from Blood Cultures?

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