Bacteremia, without Endocarditis, due to Streptococcus gallolyticus Subspecies gallolyticus in an Infant with Tetralogy of Fallot

Rizzo, Viviana; Caprio, Giovanni Di; Carannante, Novella; Rescigno, Carolina; Rossi, Marco; Bernardo, Mariano; Cuccurullo, Susanna; Tascini, Carlo

doi:10.1055/s-0037-1608701

Cited by 3 publications

(8 citation statements)

References 10 publications

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“…Progress in molecular techniques is leading to changes in the species classification. Hence, frequent ambiguities arise in describing the clinical significance of particular species, especially in human medicine [10,17,18]. In this work, the classification and nomenclature are based on data approved by the International Committee on Systematics of Prokaryotes and published in the International Journal of Systematic and Evolutionary Microbiology and the List of Prokaryotic names with Standing in Nomenclature.…”

Section: Streptococci Classificationmentioning

confidence: 99%

“…The SBSEC is a group with a changing nomenclature. Over the years, there have been changes in the division of species into groups and the naming of species based on progress in laboratory identification techniques [17][18][19]. Bacteria of this group are commensals, bacteria associated with food fermentation processes and opportunistic pathogens [10].…”

Section: Clinical Characteristics Of Groups and Species Of Streptococmentioning

confidence: 99%

“…Systemic infections may, therefore, be associated with damage to the gastrointestinal mucosa. The possibility of translocation of bacteria constituting the intestinal microbiome, which is the trigger of bacteraemia and sepsis, is also mentioned as the cause of SGG infection [17]. SGG in adults is most commonly associated with endocarditis or bacteraemia [43].…”

Section: Streptococcus Gallolyticus Subsp Gallolyticus (Sgg)mentioning

confidence: 99%

“…Antimicrobial susceptibility data for SGG are insufficient. One study on infant infection reported that the SGG strain was susceptible to penicillin, ceftriaxone, gentamicin and vancomycin [17]. Single SGG strains resistant to erythromycin have emerged [45].…”

Section: Streptococcus Gallolyticus Subsp Gallolyticus (Sgg)mentioning

confidence: 99%

“…Bacteria of this group are commensals, bacteria associated with food fermentation processes and opportunistic pathogens [10]. Correct identification of the species in this group is essential as they cause various infections with a different clinical course [17]. In the identification procedures, phenotypic biochemical methods are no longer used due to the high phenotypic variability.…”

Section: Introductionmentioning

confidence: 99%

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Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Bacteria of the genus Streptococcus , earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis , S. dysgalactiae , S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining new properties and virulence factors by which they can thrive in new environments. It shows the potential of these bacteria to changes in the genome and the settlement of new hosts. Information is presented on clinical cases that concern streptococcus species belonging to the groups Bovis, Pyogenic and Suis. We also present the antibiotic resistance profiles of these bacteria. The emerging resistance to β-lactams has been reported. In this review, the classification, clinical characteristics and antibiotic resistance of groups and species of streptococci considered as animal pathogens are summarized.

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Section: Streptococci Classificationmentioning

confidence: 99%

Section: Clinical Characteristics Of Groups and Species Of Streptococmentioning

confidence: 99%

Section: Streptococcus Gallolyticus Subsp Gallolyticus (Sgg)mentioning

confidence: 99%

Section: Streptococcus Gallolyticus Subsp Gallolyticus (Sgg)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Phenotypic and Genotypic Characterization of Antimicrobial Resistance in Streptococci Isolated from Human and Animal Clinical Specimens

2023

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Recently, the phenomenon of infection of humans as hosts by animal pathogens has been increasing. Streptococcus is an example of a genus in which bacteria overcome the species barrier. Therefore, monitoring infections caused by new species of human pathogens is critical to their spread. Seventy-five isolates belonging to streptococcal species that have recently been reported as a cause of human infections with varying frequency, were tested. The aim of the study was to determine the drug resistance profiles of the tested strains, the occurrence of resistance genes and genes encoding the most important streptococcal virulence factors. All tested isolates retained sensitivity to β-lactam antibiotics. Resistance to tetracyclines occurred in 56% of the tested strains. We have detected the MLSB type resistance (cross-resistance to macrolide, lincosamide, and streptogramin B) in 20% of the tested strains. 99% of the strains had tetracycline resistance genes. The erm class genes encoding MLSB resistance were present in 47% of strains. Among the strains with MLSB resistance, 92% had the streptokinase gene, 58% the streptolysin O gene and 33% the streptolysin S gene. The most extensive resistance concerned isolates that accumulated the most traits and genes, both resistance genes and virulence genes, increasing their pathogenic potential. Among the tested strains, the gene encoding streptokinase was the most common. The results of the prove that bacteria of the species S. uberis, S. dysgalactiae and S. gallolyticus are characterized by a high pathogenic potential and can pose a significant threat in case of infection of the human body.

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Clinical Course and Outcomes of Infants with Streptococcus bovis/Streptococcus Gallolyticus subspecies pasteurianus Infection: A Systematic Review and Meta-analysis

Jaya-Bodestyne,

Tan,

Sultan

et al. 2024

Pediatric Infectious Disease Journal

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Background: Streptococcus gallolyticus subspecies pasteurianus (SGP), a subtype of Streptococcus bovis, is an uncommon but important cause of neonatal sepsis. Although uncommon, SGP infections during infancy have been associated with an increased risk of morbidity and mortality. Methods: This is a systematic review and meta-analysis of available literature on the clinical course and outcomes of infants with SGP infection. Studies were identified using the following MeSH keywords: “Streptococcus gallolyticus,” “Streptococcus bovis,” “newborn” and “infant.” Data including perinatal factors, clinical presentation, investigations, treatment and outcomes were extracted and analyzed. Results: A total of 46 articles were identified (116 cases: 60 S. bovis, 56 SGP). The cases were predominantly term (52%), male (57%) and born via vaginal delivery (67%). The most common symptom was fever [67% (95% confidence interval (CI): 43%–84%)], lethargy [66% (95% CI: 32%–89%)], tachypnea [59% (95% CI: 27%–85%)] and irritability [59% (95% CI: 34%–79%)]. Infants with early-onset infections (<3 days of life) were more likely to have respiratory symptoms and bacteremia (73%), whereas late-onset infections presented predominantly with gastrointestinal symptoms. Four mortalities were reported which occurred before antibiotic administration. Isolated bacteria were mostly penicillin-susceptible [95% (95% CI: 78–99%)] and cases treated with penicillin derivative had good recovery. Conclusions: SGP is an important cause of neonatal sepsis and meningitis. Penicillin derivative is an effective treatment for SGP, and outcomes appear to be favorable.

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Bacteremia, without Endocarditis, due to Streptococcus gallolyticus Subspecies gallolyticus in an Infant with Tetralogy of Fallot

Cited by 3 publications

References 10 publications

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Phenotypic and Genotypic Characterization of Antimicrobial Resistance in Streptococci Isolated from Human and Animal Clinical Specimens

Clinical Course and Outcomes of Infants with Streptococcus bovis/Streptococcus Gallolyticus subspecies pasteurianus Infection: A Systematic Review and Meta-analysis

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