Bacteremic cellulitis caused by Non-01, Non-0139 Vibrio cholerae: report of a case in a patient with hemochromatosis

Fernández, Juan Manuel; Serrano, Mercedes; Arriba, J. J. de; Sánchez, Ma Victoria; Escribano, Elena; Ferreras, Pedro

doi:10.1016/s0732-8893(99)00153-4

Cited by 38 publications

(29 citation statements)

References 16 publications

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“…The FAR is related to the bacterial concentration ( Figure 6). Gross serosal hemorrhage (Figure 1) was also found to be similar with previous reports [6,[79][80][81][82][83]. The histopathological sections reflected trans mural congestion and excessive ulceration in mucosa and submucosa which also support the previous report [6,[84][85][86][87][88].…”

Section: Discussionsupporting

confidence: 90%

Isolation of Vibrio cholerae in Homogenized Tissues of Liver, Gall Bladder and Bile in Rabbit Model

Abdullah

Aamenah³

et al. 2014

Interdiscip J Microinflammation

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Vibrio cholerae O139 is well known as the causative agent of cholera. It is noninvasive but many reports suggested it to cause bacteremia which brings in a little controversy with the previously reported old literature especially after reported histopathological invasion pattern of Vibrio cholerae O139 and Vibrio cholerae O1 ElTor. The rabbits were processes for ileac loops inoculation of Vibrio cholerae O139 followed by biochemical and molecular analysis of the presence of Vibrio cholerae O139 in liver, gall bladder and bile. We concluded the presence of Vibrio cholerae in liver, bile and gall bladder homogenized tissue. Retrograde spreading of bacteria to the liver via the common bile duct was excluded by complete closure of the intestinal lumen distant to the duct in the intestinal lumen. However, the bacteria might traffic, probably via macrophages, to distant area in the body including the liver. Another study in future is a need to identify the lesions of Vibrio cholerae invasions within liver and gall bladder by immunohistochemistry and using GFP visibility for Vibrio cholerae passage.

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Section: Discussionsupporting

confidence: 90%

Isolation of Vibrio cholerae in Homogenized Tissues of Liver, Gall Bladder and Bile in Rabbit Model

Abdullah

Aamenah³

et al. 2014

Interdiscip J Microinflammation

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“…Individuals with hemochromatosis are more susceptible to infection by certain pathogens. For example, increased risks for infections with E. coli (125), V. cholerae (126), Y. enterocolitica (127), and Listeria monocytogenes (128) are associated with iron overload. HH patients are also vulnerable to infection by Vibrio vulnificus.…”

Section: Iron Status and Susceptibility To Infectionmentioning

confidence: 99%

Sequestration and Scavenging of Iron in Infection

2013

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The proliferative capability of many invasive pathogens is limited by the bioavailability of iron. Pathogens have thus developed strategies to obtain iron from their host organisms. In turn, host defense strategies have evolved to sequester iron from invasive pathogens. This review explores the mechanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in bacterial virulence, and iron-related genes required for the establishment or maintenance of infection. Host defenses to limit iron availability for bacterial growth during the acute-phase response and the consequences of iron overload conditions on susceptibility to bacterial infection are also examined. The evidence summarized herein demonstrates the importance of iron bioavailability in influencing the risk of infection and the ability of the host to clear the pathogen.

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“…Finding this Vibrio in blood culture is rare, it happening only in immunosuppressed patients or those with some base disease [2][3][4][5][6][7][8][9].…”

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confidence: 99%