Bacteria: A novel source for potent mosquito feeding-deterrents

Kajla, Mayur K.; Barrett-Wilt, Gregory A.; Paskewitz, Susan M.

doi:10.1126/sciadv.aau6141

Cited by 30 publications

(19 citation statements)

References 39 publications

(54 reference statements)

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“…Recently, a mixture of compounds isolated from Xenorhabdus budapestensis (entomopathogenic-associated bacteria) exhibited potent feeding-deterrent activity against three mosquito species considered to be the most important vectors of diseases affecting public health. They belong to the fabclavine class and exhibit a high activity comparable to or better than that of DEET or picaridin in side-by-side assays [93], which supports the attempt to replace toxic molecules by considering bacteria as a very promising source of new alternative molecules for exploitation as mosquito repellents.…”

Section: Bacterial-based Feeding Deterrents and Repellentsmentioning

confidence: 73%

“…Mosquitos are mostly attracted to humans by the lactic acid and CO 2 present in our sweat that are detected by chemoreceptors present in their antennae, and repellents mask the human scent [8]. DEET (N,N-diethyl-meta-toluamide) is the most widely used and effective repellent against mosquitoes [93].…”

Section: Mosquito Repellentsmentioning

confidence: 99%

“…Biobased mosquito repellents are pest management tools that are based on safe, biologically based active ingredients derived from plants [94,95], fungi [96], or bacteria [93].…”

Section: Mosquito Repellentsmentioning

confidence: 99%

“…Several other bacteria showing promising results on numerous pests have been suggested to have the same effect on mosquitoes, such as the entomopathogenic nematode-associated bacteria Xenorhabdus sp. [93,214]; Serratia marcescens, which is often associated with insect infection and shows high insecticidal effects alone [215] or when associated with other insecticides [216]; and entomopathogens [217]. Other bacteria exhibiting toxic effects on mosquitoes, such as Clostridium bifermentans [132], may also be considered in control strategies.…”

Section: New Insecticide Igr and Repellent Compoundsmentioning

confidence: 99%

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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

2020

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Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most important mosquito-borne diseases, such as arboviruses and malaria. This resurgence may be the consequence of numerous complex parameters, but the major cause remains the mismanagement of insecticide use and the emergence of resistance. Biological control programmes have rendered promising results but several highly effective techniques, such as genetic manipulation, remain insufficiently considered as a control mechanism. Currently, new strategies based on attractive toxic sugar baits and new agents, such as Wolbachia and Asaia, are being intensively studied for potential use as alternatives to chemicals. Research into new insecticides, Insect Growth Regulators, and repellent compounds is pressing, and the improvement of biological strategies may provide key solutions to prevent outbreaks, decrease the danger to at-risk populations, and mitigate resistance.Pathogens 2020, 9, 310 2 of 26 are not used at all, and those that are still in the test or design phase but are very promising, which we suggest to be considered in the biological control of mosquito-borne diseases.

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Section: Bacterial-based Feeding Deterrents and Repellentsmentioning

confidence: 73%

Section: Mosquito Repellentsmentioning

confidence: 99%

“…Biobased mosquito repellents are pest management tools that are based on safe, biologically based active ingredients derived from plants [94,95], fungi [96], or bacteria [93].…”

Section: Mosquito Repellentsmentioning

confidence: 99%

Section: New Insecticide Igr and Repellent Compoundsmentioning

confidence: 99%

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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

2020

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“…These bioactive compounds may be the cause of death for Aedes agypti larvae. In addition, fabclavines extracted from X. budapestensis showed potential repellent and feeding‐deterrent activities against adult mosquitoes (Kajla, Barrett‐Wilt, & Paskewitz, ). However, the mechanism through which this bacterium kills mosquito larvae has not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Survey of entomopathogenic nematodes and associate bacteria in Thailand and their potential to control Aedes aegypti

Suwannaroj

Yimthin

Fukruksa

et al. 2020

J Applied Entomology

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Aedes aegypti is an insect vector that transmits several viruses affecting humans worldwide. Entomopathogenic nematodes (EPNs) and their symbiotic bacteria are organisms with the potential to control many insects. In this study, we did a survey aimed to identify EPNs and their symbiotic bacteria and evaluate the larvicidal activity of bacteria against Ae. aegypti. We collected 540 soil samples from 108 sites in Phitsanulok Province, lower northern Thailand. Baiting techniques and White traps were used to isolate EPNs from soil samples. By sequencing of 28S rDNA and internal transcribed spacer regions, 51 EPN isolates were identified as Steinernema surkhetense (35 isolates), Heterorhabditis indica (14 isolates) and Heterorhabditis sp. SGmg3 (two isolates). Based on sequencing of a partial region of the recA gene, 35 isolates of Xenorhabdus were identified as Xenorhabdus stockiae, and 20 Photorhabdus isolates were identified as Photorhabdus luminescens subsp. akhurstii (10 isolates), P. luminescens subsp. hainanensis (seven isolates) and P. asymbiotica subsp. australis (three isolates). Screening for larvicidal activity of bacteria against Ae. aegypti was performed in the laboratory. Xenorhabdus WB5.4 and Xenorhabdus WB12.5, which were closely related to X. stockiae, resulted in high mortality of Ae. aegypti (99.99% and 70%, respectively) at 96 hr after exposure. Comparing with control groups, mortality of Ae. aegypti larvae was low (1.11%–6.67%) after exposure for 24–96 hr. Our findings showed the potential of X. stockiae for controlling Ae. aegypti. Further studies are needed to elucidate the mechanisms through which these bacteria kill Ae. aegypti larvae.

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Agricultural Microbiomes

2023

Microbiomics and Sustainable Crop Production

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Bacteria: A novel source for potent mosquito feeding-deterrents

Abstract: This study provides evidence that insect-killing bacteria produce fabclavines that can be used to deter mosquito feeding.

Cited by 30 publications

References 39 publications

Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

Survey of entomopathogenic nematodes and associate bacteria in Thailand and their potential to control Aedes aegypti

Agricultural Microbiomes

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