Bacteria activated-macrophage membrane-coated tough nanocomposite hydrogel with targeted photothermal antibacterial ability for infected wound healing

Li, Jia; Wang, Yan Jie; Yang, Jianhai; Liu, Wenguang

doi:10.1016/j.cej.2020.127638

Cited by 62 publications

(71 citation statements)

References 59 publications

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“…coli and MM represents for macrophage membrane without any treatment. In vitro studies showed that the hydrogel coated with a pretreated macrophage membrane could specifically recognize the source bacteria, and the bacteria-killing ratio reached 98% within 5 min of NIR irradiation . The bactericidal property was significantly higher than that of the hydrogels which did not coat with the macrophage membrane.…”

Section: Photothermal Therapymentioning

confidence: 98%

“…Au NPs are also widely used in the field of biomedicine because of their chemical stability, biocompatibility, and high photothermal conversion efficiency. − A multifunctional dopamine-coated Au nanorod (Au@PDA NR)-loaded antibacterial photothermal hydrogel was developed with toughness and high strength (Figure A) . Au@PDA NRs were obtained through in situ polymerization of dopamine around the Au NRs in an alkaline solution.…”

Section: Photothermal Therapymentioning

confidence: 99%

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic therapy (PDT) show great application prospects in the prevention of wound infection and promoting wound healing. In addition, hydrogels have shown attractive advantages in the field of wound dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive hydrogels (MPRHs) that integrate the advantages of light and hydrogels are increasingly used in biomedicine, especially in the field of wound repair. However, a comprehensive review of MPRHs for wound regeneration is still lacking. This review first focuses on various types of MPRHs prepared by diverse photosensitizers, photothermal agents (PHTAs) including transition metal sulfide/oxides nanomaterials, metal nanostructure-based PHTAs, carbon-based PHTAs, conjugated polymer or complex-based PHTAs, and/or photodynamic agents (PHDAs) such as ZnO-based, black-phosphorus-based, TiO 2 -based, and small organic molecule-based PHDAs. We also then discuss how PTT, PDT, and photothermal/photodynamic synergistic therapy can modulate the microenvironments of bacteria to inhibit infection. Overall, multifunctional hydrogels with both therapeutic and tissue regeneration capabilities have been discussed and existing challenges, as well as future research directions in the field of MPRHs and their application in wound management are argued.

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Section: Photothermal Therapymentioning

confidence: 98%

Section: Photothermal Therapymentioning

confidence: 99%

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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“…In recent years, various approaches such as photodynamic therapy, chemodynamic therapy, and photothermal therapy (PTT) have emerged to fight bacteria. Among these antibacterial approaches, PTT, which can efficiently kill bacteria by physical heating, has drawn substantial interest because of its outstanding high selectivity, non-invasive nature, preferable controllability, negligible drug resistance, and less likely to induce systemic toxicity [ 5 , 6 ]. Particularly, near-infrared (NIR) light-triggered PTT has been extensively developed owing to the excellent tissue penetration of NIR light [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

You

Mao

et al. 2022

Materials Today Bio

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“…[18,19] Previous studies have designed drug carrier particles for delivering antibacterial agents to macrophages. [18,20] However, inefficient targeting and insufficient intracellular delivery of antibiotics remains an issue. [19] In addition, M2-type macrophages are associated with tumor growth and the development of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Macrophage‐Targeting Poly(lactide‐co‐glycolic acid) Nanoparticles Decorated with Multifunctional Brush Polymers

Christau

Ruiz

Habibi

et al. 2022

Part & Part Syst Charact

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In nanoparticle-based drug delivery, nanoscale materials are employed to deliver certain therapeutic agents to specific targeting sites. A major benefit of this approach lies in the ability to control the parameters of the nanocarrier, such as size, shape, density, or surface coating, which allows for a controlled and sustained delivery of therapeutics. [2] Several types of nanocarriers to encapsulate drugs of interest have been developed for efficient drug delivery to the targeting site, including lipid nanoparticles, [3] inorganic nanoparticles, [4] protein-based nanoparticles, [5] and polymeric nanoparticles. [6] The appropriate carrier type is selected based on the desired drug release profile and also depends on the interactions between the drug and the carrier particle; drugs might be encapsulated by means of covalent bonding, hydrogen bonding interactions, electrostatic interactions, or van der Waals interactions. [1] Polyester-based nanoparticles (NPs), such as poly(lactic-co-glycolic acid) (PLGA) NPs, combine chemical versatility with degradability, and they are thus often studied as potential drug delivery vehicles. [7,8] PLGA is an FDA-approved, biocompatible polymer, and PLGA NPs have been extensively studied for biomedical applications due This study examines the potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles functionalized with poly(zwitterion)-mannose brushes to target macrophages. Uptake studies with RAW 264.7 macrophages indicate that multiple mannose-binding sites in the grafted brushes facilitate interaction with the mannose receptor of the macrophages, resulting in approximately four times higher cellular uptake than nanoparticles with mannose monolayer coatings. To test the feasibility of the nanoparticles as longcirculating drug delivery vehicles, their multicomponent aggregation in blood plasma is analyzed using nanoparticle tracking analysis and compared to poly(ethylene glycol)-coated (PEGylated) particles, which are known to reduce aggregation. There is no significant difference in the aggregation behavior of the poly(zwitterion)-mannose grafted particles and the PEGylated control particles (≈760 particles in aggregates per 105 particles). In addition, the particle size in blood plasma is compared, which includes the protein corona, after 0, 8, and 15 h. Whereas there is no significant difference at longer time scales, the overall particle size of the poly(zwitterion)-mannose brush-grafted nanoparticles is ≈130 nm smaller than that of the PEGylated nanoparticles at shorter time scales, suggesting a smaller protein corona. All these results suggest that poly(lactic-co-glycolic acid nanoparticles functionalized with poly(zwitterion)-mannose brush grafts may be excellent candidates for targeted drug delivery to macrophages.The ORCID identification number(s) for the author(s) of this article can be found under

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Bacteria activated-macrophage membrane-coated tough nanocomposite hydrogel with targeted photothermal antibacterial ability for infected wound healing

Cited by 62 publications

References 59 publications

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

Macrophage‐Targeting Poly(lactide‐co‐glycolic acid) Nanoparticles Decorated with Multifunctional Brush Polymers

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