Bacteria Mediated Synthesis of Iron Oxide Nanoparticles and Their Antibacterial, Antioxidant, Cytocompatibility Properties

Majeed, Shahnaz; Danish, Mohammed; Ibrahim, Mohamad Nasir Mohamad; Sekeri, Siti Hajar; Ansari, Mohammed Tahir; Nanda, Anima; Ahmad, Gulzar

doi:10.1007/s10876-020-01876-7

Cited by 73 publications

(28 citation statements)

References 33 publications

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“…Green synthesized amorphous iron oxide NPs, which were fabricated using Blepharis maderaspantensis water extract, showed zeta potential of −20.9 ± 6.24 mV and exhibited strong antibacterial activity against MRSA and E. coli suggesting that they can be used for medicinal purposes [ 329 ]. Biogenic iron oxide NPs prepared using Proteus vulgaris ATCC-29905 (19.23 nm and 30.51 nm; zeta potential of 79.5 mV) exhibited notable antibacterial activity against MRSA; these NPs also were cytotoxic to U87 MG-glioblastoma cancer cells (IC 50 value of 250 μg/mL) and inhibited the cell migration of the HT-29 cancer cells [ 330 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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“…SEM analysis confirmed the formation of spherical 60–80-nm-sized NPs of Fe 3 O 4 . In a recent report, the antibacterial, antioxidant and cytocompatibility properties of IONPs biosynthesized using Proteus vulgaris ATCC-29905 were successfully analyzed [ 133 ]. The spherical IONPs (size 19.23–30.51 nm) showed strong antimicrobial activity against S. aureus (methicillin resistant), showed an antioxidant property, inhibited the migration of HT-29 cancer cells and exhibited a strong anticancer property against U87 MG-glioblastoma cancer cells.…”

Section: Strategies For Synthesis Of Nanoparticles Using Microbesmentioning

confidence: 99%

Microbe-Mediated Biosynthesis of Nanoparticles: Applications and Future Prospects

et al. 2021

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Nanotechnology is the science of nano-sized particles/structures (~100 nm) having a high surface-to-volume ratio that can modulate the physical, chemical and biological properties of the chemical compositions. In last few decades, nanoscience has attracted the attention of the scientific community worldwide due to its potential uses in the pharmacy, medical diagnostics and disease treatment, energy, electronics, agriculture, chemical and space industries. The properties of nanoparticles (NPs) are size and shape dependent. These characteristic features of nanoparticles can be explored for various other applications such as computer transistors, chemical sensors, electrometers, memory schemes, reusable catalysts, biosensing, antimicrobial activity, nanocomposites, medical imaging, tumor detection and drug delivery. Therefore, synthesizing nanoparticles of desired size, structure, monodispersity and morphology is crucial for the aforementioned applications. Recent advancements in nanotechnology aim at the synthesis of nanoparticles/materials using reliable, innoxious and novel ecofriendly techniques. In contrast to the traditional methods, the biosynthesis of nanoparticles of a desired nature and structure using the microbial machinery is not only quicker and safer but more environmentally friendly. Various microbes, including bacteria, actinobacteria, fungi, yeast, microalgae and viruses, have recently been explored for the synthesis of metal, metal oxide and other important NPs through intracellular and extracellular processes. Some bacteria and microalgae possess specific potential to fabricate distinctive nanomaterials such as exopolysaccharides, nanocellulose, nanoplates and nanowires. Moreover, their ability to synthesize nanoparticles can be enhanced using genetic engineering approaches. Thus, the use of microorganisms for synthesis of nanoparticles is unique and has a promising future. The present review provides explicit information on different strategies for the synthesis of nanoparticles using microbial cells; their applications in bioremediation, agriculture, medicine and diagnostics; and their future prospects.

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“…The resulting NPs showed potent antioxidant and bactericidal activity [ 17 ]. Proteus vulgaris (ATCC-29905) mediated IONPs also proved to be excellent anticancer and antimicrobial agents [ 18 ].…”

Section: Bacterial Mediated Synthesismentioning

confidence: 99%

“…In all treatments, IONPs exhibited strong cytotoxic potential against the aforementioned cancer cell lines. Microbe-mediated IONPs escalate oxidative stress and kill the cells by impeding their cell division and distorting macromolecules framework which ultimately leads to cell death via activating apoptosis [ 17 , 18 , 22 , 23 , 46 ]. The anticancer potential of IONPs is depicted in Figure 2 .…”

Section: Anticancer Activitymentioning

confidence: 99%

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A Review of Microbial Mediated Iron Nanoparticles (IONPs) and Its Biomedical Applications

et al. 2021

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Nanotechnology is a booming avenue in science and has a multitude of applications in health, agriculture, and industry. It exploits materials’ size at nanoscale (1–100 nm) known as nanoparticles (NPs). These nanoscale constituents are made via chemical, physical, and biological methods; however, the biological approach offers multiple benefits over the other counterparts. This method utilizes various biological resources for synthesis (microbes, plants, and others), which act as a reducing and capping agent. Among these sources, microbes provide an excellent platform for synthesis and have been recently exploited in the synthesis of various metallic NPs, in particular iron. Owing to their biocompatible nature, superparamagnetic properties, small size efficient, permeability, and absorption, they have become an integral part of biomedical research. This review focuses on microbial synthesis of iron oxide nanoparticles using various species of bacteria, fungi, and yeast. Possible applications and challenges that need to be addressed have also been discussed in the review; in particular, their antimicrobial and anticancer potentials are discussed in detail along with possible mechanisms. Moreover, some other possible biomedical applications are also highlighted. Although iron oxide nanoparticles have revolutionized biomedical research, issues such as cytotoxicity and biodegradability are still a major bottleneck in the commercialization of these nanoparticle-based products. Addressing these issues should be the topmost priority so that the biomedical industry can reap maximum benefit from iron oxide nanoparticle-based products.

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Bacteria Mediated Synthesis of Iron Oxide Nanoparticles and Their Antibacterial, Antioxidant, Cytocompatibility Properties

Cited by 73 publications

References 33 publications

Advances in Nanostructures for Antimicrobial Therapy

Advances in Nanostructures for Antimicrobial Therapy

Microbe-Mediated Biosynthesis of Nanoparticles: Applications and Future Prospects

A Review of Microbial Mediated Iron Nanoparticles (IONPs) and Its Biomedical Applications

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