Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication

Wang, Yingying; Shukla, Anita

doi:10.1039/d2bm00361a

Cited by 28 publications

(21 citation statements)

References 70 publications

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“…On account of the gelatinase- and hyaluronidase-promoted degradation, their antibiofilm properties were evaluated against Gram-negative wound-infecting bacteria Vibrio vulnificus ( V. vulnificus ) under biofilm mimetic conditions. 68 Here, the FDA-approved tetracycline antibiotic doxycycline (Doxy), 69 commonly used for the treatment of V. vulnificus -caused infections, was used as a model encapsulated drug. The GNPs were fabricated by the layer-by-layer (LBL) assembly of two oppositely charged coatings: polyanion HA and polycation CS, with the HA layer being exposed to the surroundings (Fig.…”

Section: Biopolymer-based Antibiofilm Agentsmentioning

confidence: 99%

Inhibition and eradication of bacterial biofilm using polymeric materials

Banerjee

Chowdhury

Bauri³

et al. 2023

Biomater. Sci.

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Section: Biopolymer-based Antibiofilm Agentsmentioning

confidence: 99%

Inhibition and eradication of bacterial biofilm using polymeric materials

Banerjee

Chowdhury

Bauri³

et al. 2023

Biomater. Sci.

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“…In addition, the farnesol-loaded nanoparticles attenuated the infection in vivo. The nanoparticles loaded with saturated farnesol enhanced biofilm eradication by 3-fold and 7-fold compared to the farnesol-loaded nanoparticles and farnesol alone [ 207 ].…”

Section: Strategies To Enhance Biofilm Clearancementioning

confidence: 99%

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

Kannappan

Prasath²,

Sathya

et al. 2023

Pathogens

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Biofilms enable pathogenic bacteria to survive in unfavorable environments. As biofilm-forming pathogens can cause rapid food spoilage and recurrent infections in humans, especially their presence in the food industry is problematic. Using chemical disinfectants in the food industry to prevent biofilm formation raises serious health concerns. Further, the ability of biofilm-forming bacterial pathogens to tolerate disinfection procedures questions the traditional treatment methods. Thus, there is a dire need for alternative treatment options targeting bacterial pathogens, especially biofilms. As clean-label products without carcinogenic and hazardous potential, natural compounds with growth and biofilm-inhibiting and biofilm-eradicating potentials have gained popularity as natural preservatives in the food industry. However, the use of these natural preservatives in the food industry is restricted by their poor availability, stability during food processing and storage. Also there is a lack of standardization, and unattractive organoleptic qualities. Nanotechnology is one way to get around these limitations and as well as the use of underutilized bioactives. The use of nanotechnology has several advantages including traversing the biofilm matrix, targeted drug delivery, controlled release, and enhanced bioavailability, bioactivity, and stability. The nanoparticles used in fabricating or encapsulating natural products are considered as an appealing antibiofilm strategy since the nanoparticles enhance the activity of the natural products against biofilms of foodborne bacterial pathogens. Hence, this literature review is intended to provide a comprehensive analysis of the current methods in nanotechnology used for natural products delivery (biofabrication, encapsulation, and nanoemulsion) and also discuss the different promising strategies employed in the recent and past to enhance the inhibition and eradication of foodborne bacterial biofilms.

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“…Polymeric particles are widely used as nanoscale drug carriers for antimicrobial delivery, as they can be fabricated from biocompatible polymers, loaded with bioactive cargo, and delivered via inhalation (27,28). In addition, polymeric particles have tunable properties such as size, shape, surface charge, and polymer composition, which can influence particle biodistribution, half-life, and interactions with biological barriers such as mucus and bacterial biofilms (29)(30)(31)(32)(33). Polyelectrolyte nanocomplexes (NCs) are an emerging class of polymeric nanoparticle drug carrier and are formed through electrostatic interactions between oppositely charged components (34,35).…”

Section: Introductionmentioning

confidence: 99%

Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections

et al. 2023

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Bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), have high rates of antimicrobial tolerance and are commonly found in chronic wound and cystic fibrosis lung infections. Combination therapeutics that act synergistically can overcome antimicrobial tolerance; however, the delivery of multiple therapeutics at relevant dosages remains a challenge. We therefore developed a nanoscale drug carrier for antimicrobial codelivery by combining approaches from polyelectrolyte nanocomplex (NC) formation and layer-by-layer electrostatic self-assembly. This strategy led to NC drug carriers loaded with tobramycin antibiotics and antimicrobial silver nanoparticles (AgTob-NCs). AgTob-NCs displayed synergistic enhancements in antimicrobial activity against both planktonic and biofilm PA cultures, with positively charged NCs outperforming negatively charged formulations. NCs were evaluated in mouse models of lung infection, leading to reduced bacterial burden and improved survival outcomes. This approach therefore shows promise for nanoscale therapeutic codelivery to treat recalcitrant bacterial infections.

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Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication

Abstract: Biofilm infections are common and can be extremely difficult to treat. Bacteria-responsive nanoparticles that respond to multiple bacterial stimuli have the potential to successfully prevent and eradicate biofilms. Here, we...

Cited by 28 publications

References 70 publications

Inhibition and eradication of bacterial biofilm using polymeric materials

Inhibition and eradication of bacterial biofilm using polymeric materials

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections

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