Bacteria Survival Strategies in Contact With Antibiotics

Chebotar, I. V.; Bocharova, Yu.A.; Гурьев, А. С.; Mayanskiy, Nikolay

doi:10.18821/0869-2084-2020-65-2-116-121

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Antibiotics have played a significant role in the prevention, containment, and treatment of infectious diseases in animals [6]. The extensive utilization of antibiotics has also contributed to the significant issue of bacterial resistance [7][8][9]. More significantly, the proliferation of bacterial resistance poses a grave menace to global public health [9].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Ma,

Huang,

Cheng

2023

IJMS

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Pathogen detection and control have long presented formidable challenges in the domains of medicine and public health. This review paper underscores the potential of nanozymes as emerging bio-mimetic enzymes that hold promise in effectively tackling these challenges. The key features and advantages of nanozymes are introduced, encompassing their comparable catalytic activity to natural enzymes, enhanced stability and reliability, cost effectiveness, and straightforward preparation methods. Subsequently, the paper delves into the detailed utilization of nanozymes for pathogen detection. This includes their application as biosensors, facilitating rapid and sensitive identification of diverse pathogens, including bacteria, viruses, and plasmodium. Furthermore, the paper explores strategies employing nanozymes for pathogen control, such as the regulation of reactive oxygen species (ROS), HOBr/Cl regulation, and clearance of extracellular DNA to impede pathogen growth and transmission. The review underscores the vast potential of nanozymes in pathogen detection and control through numerous specific examples and case studies. The authors highlight the efficiency, rapidity, and specificity of pathogen detection achieved with nanozymes, employing various strategies. They also demonstrate the feasibility of nanozymes in hindering pathogen growth and transmission. These innovative approaches employing nanozymes are projected to provide novel options for early disease diagnoses, treatment, and prevention. Through a comprehensive discourse on the characteristics and advantages of nanozymes, as well as diverse application approaches, this paper serves as a crucial reference and guide for further research and development in nanozyme technology. The expectation is that such advancements will significantly contribute to enhancing disease control measures and improving public health outcomes.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Ma,

Huang,

Cheng

2023

IJMS

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“…Nearly a quarter of global mortality is caused by infectious diseases, and bacterial infection is one of the major contributors [1,2]. Conventional antibiotics have saved millions of lives since being introduced to clinical practice in the 1930s, by controlling bacterial infections [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Facile multifunctional-mode of fabricated biocompatible human serum albumin/reduced graphene oxide/Cladophora glomerata nanoparticles for bacteriostatic phototherapy, bacterial tracking and antioxidant potential

et al. 2021

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To overcome multi-drug resistance in microbes, highly efficient antimicrobial substances are required that have a controllable antibacterial effect and are biocompatible. In the present study, an efficient phototherapeutic antibacterial agent, human serum albumin (HSA)/reduced graphene oxide (rGO)/Cladophora glomerata bionanocomposite was synthesized by the incorporation of rGO nanoparticles with HSA, forming protein-rGO, and decorated with a natural freshwater seaweed Cladophora glomerata. The prepared HSA/rGO/Cladophora glomerata bionanocomposite was characterized by spectroscopic (UV-vis, FTIR, XRD and Raman) and microscopic (TEM and SEM) techniques. The as-synthesized bionanocomposite showed that sunlight/NIR irradiation stimulated ROS-generating dual-phototherapic effects against antibiotic-resistant bacteria. The bionanocomposite exerted strong antibacterial effects (above 96 %) against amoxicillin-resistant P. aeruginosa and S. aureus, in contrast to single-model-phototherapy. The bionanocomposite not only generated abundant ROS for killing bacteria, but also expressed a fluorescence image for bacterial tracking under sunlight/NIR irradiation. Additionally, the bionanocomposite displayed pronounced antioxidant activity.

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Molecular determinants of antibiotic resistance in Salmonella enterica antibiotic resistance

Pavlova

Бочарова

Kuleshov

et al. 2022

Journal of microbiology, epidemiology and immunobiology

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Nontyphoid strains of Salmonella enterica pose a great threat to human health. The problem of salmonellosis is aggravated compounded by the progressive spread of antibiotic resistance among clinical and agricultural strains of S. enterica. This literature review summarizes the current knowledge of the mechanisms of antibiotic resistance in S. enterica and illustrates the diversity and complexity of molecular systems providing antibiotic resistance. The spectrum of natural resistance is described and the adaptive (acquired) mechanisms of resistance to representatives of the main classes of antibiotics, including fluoroquinolones, aminoglycosides, tetracyclines, nitrofurans, sulfonamides, fosfomycin and chloramphenicol, are thoroughly characterized. Particular emphasis is placed on the analysis of the molecular genetic mechanisms of S. enterica resistance to representatives of the most important classes of antibiotics — β-lactams, and to reserve antibiotics — polymyxins (colistin). Genetic determinants of resistance, transmitted by a horizontal path route are also described. The review analyzes only those variants of the molecular mechanisms of antibiotic resistance where the clinical significance has been proven by a set of correct genetic (sequencing) and biochemical (confirmation of the spectrum of hydrolyzed β-lactams) studies. The main ways of regulating the expression of antibiotic resistance are also described. Many S. enterica strains exhibit a combination of different mechanisms of antibiotic resistance and have a multiple resistance. The question was raised about the heterogeneity of the distribution of resistance among different groups/serotypes within the S. enterica species. In particular, some clonal complexes with signs of resistance are more successful pathogens in humans and animals. Salmonella, like most other bacteria, exhibit a non-canonical type of antibiotic resistance — biofilm resistance, which is realized through several mechanisms, the main of which are the filtering/sorption capacity of the biofilm matrix and the transformation of biofilm cells into dormant and persistent forms.Despite the fact that the functional significance of the molecular assemblies that determine antibiotic resistance is the same for all enterobacteria, the specification of the mechanisms of resistance in Salmonella is a necessary link for the development of molecular diagnostic systems for assessing the sensitivity to antimicrobial drugs.

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Bacteria Survival Strategies in Contact With Antibiotics

Cited by 5 publications

References 25 publications

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Facile multifunctional-mode of fabricated biocompatible human serum albumin/reduced graphene oxide/Cladophora glomerata nanoparticles for bacteriostatic phototherapy, bacterial tracking and antioxidant potential

Molecular determinants of antibiotic resistance in Salmonella enterica antibiotic resistance

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