Bacterial adhesion: From mechanism to control

Hori, Katsutoshi; Matsumoto, Shimpei

doi:10.1016/j.bej.2009.11.014

Cited by 640 publications

(472 citation statements)

References 170 publications

(188 reference statements)

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“…The potential mechanisms of synergistic effect between Ag and antibiotics are considered to include attacking the same target, binding of monomers to the membrane, and stimulating bactericidal agent penetration 23,[42][43][44][45][46][47][48][49] ( Figure 6). Specifically, vancomycin kills bacteria by blocking the molecules called peptidoglycans, which reinforce the bacterial cell wall; this is also the target of Ag.…”

Section: Discussionmentioning

confidence: 99%

Silver-loaded nanotubular structures enhanced bactericidal efficiency of antibiotics with synergistic effect in vitro and in vivo

Cheng

et al. 2017

IJN

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Antibiotic-resistant bacteria have become a major issue due to the long-term use and abuse of antibiotics in treatments in clinics. The combination therapy of antibiotics and silver (Ag) nanoparticles is an effective way of both enhancing the antibacterial effect and decreasing the usage of antibiotics. Although the method has been proved to be effective in vitro, no in vivo tests have been carried out at present. Herein, we described a combination therapy of local delivery of Ag and systemic antibiotics treatment in vitro in an infection model of rat. Ag nanoparticle-loaded TiO 2 nanotube (NT) arrays (Ag-NTs) were fabricated on titanium implants for a customized release of Ag ion. The antibacterial properties of silver combined with antibiotics vancomycin, rifampin, gentamicin, and levofloxacin, respectively, were tested in vitro by minimum inhibitory concentration (MIC) assay, disk diffusion assay, and antibiofilm formation test. Enhanced antibacterial activity of combination therapy was observed for all the chosen bacterial strains, including gram-negative Escherichia coli (ATCC 25922), gram-positive Staphylococcus aureus (ATCC 25923), and methicillin-resistant Staphylococcus aureus (MRSA; ATCC 33591 and ATCC 43300). Moreover, after a relative short (3 weeks) combinational treatment, animal experiments in vivo further proved the synergistic antibacterial effect by X-ray and histological and immunohistochemical analyses. These results demonstrated that the combination of Ag nanoparticles and antibiotics significantly enhanced the antibacterial effect both in vitro and in vivo through the synergistic effect. The strategy is promising for clinical application to reduce the usage of antibiotics and shorten the administration time of implant-associated infection.

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Section: Discussionmentioning

confidence: 99%

Silver-loaded nanotubular structures enhanced bactericidal efficiency of antibiotics with synergistic effect in vitro and in vivo

Cheng

et al. 2017

IJN

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“…Interaction of bacterial cells with various surfaces has been studied for many years, especially with respect to biofouling. For instance, coating materials which have the ability to decrease bacterial attachment to the surface have many applications in medical implants, food processing, agriculture and ship design [31][32][33]. Many reports describe that seeding different bacterial strains onto similar surfaces results in different amounts of adherence [33,34].…”

Section: Introductionmentioning

confidence: 99%

Tunable conjugated polymers for bacterial differentiation

Golabi

Turner

Jager

2016

Sensors and Actuators B: Chemical

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A novel rapid method for bacterial differentiation is explored based on the specific adhesion pattern of bacterial strains to tunable polymer surfaces. Different types of counter ions were used to electrochemically fabricate dissimilar polypyrrole (PPy) films with diverse physicochemical properties such as hydrophobicity, thickness and roughness. These were then modulated into three different oxidation states in each case. The dissimilar sets of conducting polymers were Principal Component Analysis showed that each strain of bacteria had its own specific adhesion pattern. Hence, they could be discriminated by this simple, label-free method. , based on tunable polymer arrays combined with pattern recognition.

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“…10,11 The process of bacterial adherence is generally thought to be governed by van der Waals interactions, such that the bacteria reach the surface of the artificial material by overcoming energy barriers, through electrostatic repulsion, and then form colonies by way of reversible/irreversible adhesion. 12,13 Research has shown that polysaccharide intercellular adhesin (PIA) plays an important role in bacterial adhesion as well as in biofilm formation. [14][15][16][17] However, the exact mechanism of adhesion has yet to be determined because of the complex combination of numerous other factors related to the bacteria, the in vivo environment, and the artificial material involved.…”

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confidence: 99%