Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease

D’Anna, Silvestro Ennio; Maniscalco, Mauro; Cappello, Francesco; Carone, Mauro; Motta, Andréa; Balbi, Bruno; Ricciardolo, Fabio Luigi Massimo; Caramori, Gaetano; Stefano, Antonino Di

doi:10.1080/07853890.2020.1831050

Cited by 44 publications

(31 citation statements)

References 148 publications

(211 reference statements)

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“…Statistics are important, whether from administrative data, surveys or controlled studies. Asthma and other chronic obstructive lung diseases are silent killers; therefore information pertaining these diseases is important to guide decision making for quality health service provision (D'Anna et al 2021;Shayo and Bintabara 2019;Sharma et al 2018). In this study, we have tested for region and tted a related prediction model for ACOLD incidence rates.…”

Section: Discussionmentioning

confidence: 99%

Modeling Incidence Rate by Region: Analysis of Asthma and Other Chronic Obstructive Lung Diseases

Wesonga

Abdelbasit

2021

Preprint

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This study aimed to examine regional differences for asthma and other chronic obstructive lung diseases. The study was based on data collected from annual reports produced by the Ministry of Health over a ten-year period beginning from 2010 to 2019. Incidence rates for eleven regions in the Sultanate of Oman were analyzed using statistical tools including; analysis of variance and binary logistic regression model to determine the effect of region on asthma and other chronic obstructive lung diseases. The incident rates were found to be significantly different by region (F-value = 27.07, p = 0.00). There was no significant variation by year (F-value = 1.05, p > 0.407). Overall over the ten-year period the incidence rates stagnated between 250 and 300 per 10000 of the population, but showed a reducing trend between 2016 and 2019. The logistic regression model shows that compared to the Muscat region, all the other regions had significant increased odd ratios. There is a significant evidence of regional variation in the incidence of asthma and other chronic obstructive lung diseases. This implies probable characteristics in geographical regions that are associated with asthma and other chronic obstructive lung diseases’ exacerbation. Five asthma-region classifications were identified from our analysis. Findings of this study may be used to guide decision making towards the management and control of asthma and chronic obstructive lung diseases.

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Section: Discussionmentioning

confidence: 99%

Modeling Incidence Rate by Region: Analysis of Asthma and Other Chronic Obstructive Lung Diseases

Wesonga

Abdelbasit

2021

Preprint

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“…Open access and increase airway inflammation. [5][6][7] It has been found that 40%-55% of COPD exacerbations are associated with bacterial infections. 8 9 COPD flare-ups caused by bacterial infections are characterised by a more severe airway and systemic inflammation responses compared with those caused by non-bacterial infections.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Eosinopenia as a biomarker for antibiotic use in COPD exacerbations: protocol for a retrospective hospital-based cohort study

Yang

Liu

et al. 2022

BMJ Open

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IntroductionThe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has a seriously negative impact on patients’ healths condition and disease progression. Bacterial infection is closely related to AECOPD, and antibiotics are frequently used in clinical practice. The lack of specific biomarkers for rational antibiotics use always leads to antibiotics abuse in chronic obstructive pulmonary disease (COPD) flare-ups. Eosinopenia has been considered to be related to increased bacterial load of potentially pathogenic organisms at the onset of COPD exacerbations. Therefore, this study aims to investigate whether eosinopenia could be used as a reference for the use of antibiotics in AECOPD.Methods and analysisIn this study, a hospital-based retrospective cohort design will be adopted to analyse the clinical data of inpatients who are primarily diagnosed with AECOPD in West China Hospital of Sichuan University from 1 January 2010 to 31 December 2020. Relevant data will be extracted from the Clinical Big Data Platform for Scientific Research in West China Hospital, including demographic characteristics, blood eosinophil count, procalcitonin, C reactive protein, microbial cultivation, antibiotics use, length of hospital stay, non-invasive ventilation use, intensive care unit transfer and mortality, etc. The collected data will be described and inferred by corresponding statistical methods according to the data type and their distributions. Multiple binary logistic regression models will be used to analyse the relationship between blood eosinophil count and bacterial infection. The antibiotics use, and patient morbidity and mortality will be compared between patients with or without eosinopenia.Ethics and disseminationThis study has been approved by the Biomedical Ethics Review Board of West China Hospital of Sichuan University (Approval No. 2020-1056). And the research results will be published in a peer-reviewed journal.Trial registration numberChiCTR2000039379.

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Section: Anelloviruses and Chronic Respiratory Diseasesmentioning

confidence: 99%

“…However, mechanisms causing asthma exacerbations are still not fully understood and are different among children [ 77 , 78 ]. Hence, a better comprehension of the underlying pathogenic processes could lead to further treatment options [ 78 , 79 ]. The introduction of non-culture-based methods (i.e., next-generation sequencing technologies) has yielded the detection of previously unknown human pathogens [ 80 , 81 ], leading to better investigating the host–microbiome interactions and specifically the part of the virome in lung diseases [ 80 ].…”

Section: Anelloviruses and Chronic Respiratory Diseasesmentioning

confidence: 99%

Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases

et al. 2021

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More recently, increasing attention has been directed to exploring the function of the global virome in health and disease. Currently, by new molecular techniques, such as metagenomic DNA sequencing, the virome has been better unveiled. By investigating the human lung virome, we could provide novel insights into respiratory diseases. The virome, as a part of the microbiome, is characterized by a constant change in composition related to the type of diet, environment, and our genetic code, and other incalculable factors. The virome plays a substantial role in modulating human immune defenses and contributing to the inflammatory processes. Anelloviruses (AVs) are new components of the virome. AVs are already present during early life and reproduce without apparently causing harm to the host. The role of AVs is still unknown, but several reports have shown that AVs could activate the inflammasomes, intracellular multiprotein oligomers of the innate immune system, which show a crucial role in the host defense to several pathogens. In this narrative revision, we summarize the epidemiological data related to the possible link between microbial alterations and chronic respiratory diseases in children. Briefly, we also describe the characteristics of the most frequent viral family present in the lung virome, Anelloviridae. Furthermore, we discuss how AVs could modulate the immune system in children, affecting the development of chronic respiratory diseases, particularly asthma, the most common chronic inflammatory disease in childhood.

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Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease

Cited by 44 publications

References 148 publications

Modeling Incidence Rate by Region: Analysis of Asthma and Other Chronic Obstructive Lung Diseases

Modeling Incidence Rate by Region: Analysis of Asthma and Other Chronic Obstructive Lung Diseases

Eosinopenia as a biomarker for antibiotic use in COPD exacerbations: protocol for a retrospective hospital-based cohort study

Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases

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