Bacterial antagonism in host-associated microbial communities

García-Bayona, Leonor; Comstock, Laurie E.

doi:10.1126/science.aat2456

Cited by 270 publications

(215 citation statements)

References 136 publications

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“…Accordingly, the expression of Bcl-6, a transcription factor essential for the differentiation and function of Tfh cells (22), was also significantly reduced (Fig. 3, F Commensal microbes calibrate immune responses in large part by producing small molecules that mediate host-microbial interactions (23,24). Thus, we explored the immunomodulatory properties of salivaricins, the key anti-competitor or signaling molecules mediating the benefits of S. salivarius (18).…”

Section: With Respect To Specific Taxonomical Groups Prevotella Fusmentioning

confidence: 99%

Mining the human tonsillar microbiota as autoimmune modulator

Li²,

Jin

et al. 2019

Preprint

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Palatine tonsils are important lymphoid organs featuring constant cross-talks between the commensal microorganisms and immune system, and have been implicated as critical autoimmunity origins for immune-related diseases, including rheumatoid arthritis (RA), a common autoimmune disorder. However, there was no evidence to show link between tonsillar microbiota and RA. Here, we identified a significant dysbiosis of RA tonsillar microbiota, with loss of Streptococcus salivarius and its functional molecules salivaricins (a type of antibacterial peptides). Consistent with the niche-preference, S. salivarius and salivaricins administrated intranasally or intraorally conferred prophylactic and therapeutic efficacies against experimental arthritis. Moreover, we demonstrated, for the first time, that S. salivarius and salivaricins exerted immunosuppressive capacities via inhibiting CD4+effector T cell subsets and autoantibody production in mice and human. These results uncover a communication between tonsillar microbiota and host autoimmunity, and identify the active components from tonsillar microbes in modulating immune homeostasis.One sentence summaryTonsillar microbiota regulate host autoimmunity via antibacterial peptides

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Section: With Respect To Specific Taxonomical Groups Prevotella Fusmentioning

confidence: 99%

Mining the human tonsillar microbiota as autoimmune modulator

Li²,

Jin

et al. 2019

Preprint

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“…Strains with insertions of pNBU2 were selected for matching integration sites by PCR with primers flanking att loci (46). Interbacterial competitions between strains of B. fragilis occasionally exhibited T6SS-independent phenotypes that were dependent on the initial starting ratio of the strains used (47).…”

Section: Interbacterial Competition Assaysmentioning

confidence: 99%

Acquired interbacterial defense systems protect against interspecies antagonism in the human gut microbiome

Ross

et al. 2018

Preprint

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The impact of direct interactions between co-resident microbes on microbiome composition is not well understood. Here we report the occurrence of acquired interbacterial defense (AID) gene clusters in bacterial residents of the human gut microbiome. These clusters encode arrays of immunity genes that protect against type VI secretion toxin-mediated intra-and inter-species bacterial antagonism. Moreover, the clusters reside on mobile elements and we demonstrate that their transfer is sufficient to confer toxin resistance in vitro and in gnotobiotic mice. Finally, we identify and validate the protective capacity of a recombinase-associated AID subtype (rAID-1) present broadly in Bacteroidales genomes. These rAID-1 gene clusters have a structure suggestive of active gene acquisition and include predicted immunity factors of toxins deriving from diverse organisms. Our data suggest that neutralization of contact-dependent interbacterial antagonism via AID systems shapes human gut microbiome ecology.

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“…Coevolutionary theories are now well developed and have been applied in many fields, such as cosmology (Heckman and Kauffmann, 2011;Martin-Navarro et al, 2018;Wu et al, 2015). Sociology (Henrich et al, 2006), computer science (Liu and Lu, 2015), biology (Bottery et al, 2019;Chen et al, 2020;Cross et al, 2019;Garcia-Bayona and Comstock, 2018), biomedicine (Bottery et al, 2017;Loftie-Eaton et al, 2016;Single et al, 2007), and molecular biology (Barreto et al, 2018;Jin et al, 2017b;Lord et al, 2019;Mann et al, 2016). The interactions between promoters and transcription factors (TFs) are the beginning of gene transcription, and it has been acknowledged that such interactions are vital for transcription regulation and could affect all stages of cell lifecycle (Mirny, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

Zhang

et al. 2020

Preprint

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Coevolution has been acknowledged to play a significant role in driving the evolution of molecules and species. Promoters and transcription factors (TFs), especially their interactions, are key determinants for the regulation of gene expression. However, the evolutionary processes and mechanisms of promoter and TF interactions are still poorly understood. Here we conduct extensive physicochemical analyses of multi-omics sequences in 440 animal species and 223 plant species which span nearly one billion years of phylogeny. We demonstrate that promoters and TFs obey antagonistic coevolution in the animal kingdom while follow mutualistic coevolution in the plant kingdom. Furthermore, we reveal that such two coevolutionary strategies result in different evolutionary transitions of transcriptional networks in the two kingdoms. These results suggest that the two distinct coevolutionary mechanisms are likely to be major drivers of far greater genetic divergence between animals and plants, and open a new door to understanding the roles of promoters and TFs in tumor initiation and progression, and human ageing as well in molecular interactions and evolution.

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Bacterial antagonism in host-associated microbial communities

Cited by 270 publications

References 136 publications

Mining the human tonsillar microbiota as autoimmune modulator

Mining the human tonsillar microbiota as autoimmune modulator

Acquired interbacterial defense systems protect against interspecies antagonism in the human gut microbiome

The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

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