Bacterial anti-adhesive and pH-induced antibacterial agent releasing ultra-thin films of zwitterionic copolymer micelles

Onat, Bora; Bütün, Vural; Banerjee, Sreeparna; Erel-Göktepe, Irem

doi:10.1016/j.actbio.2016.04.033

Cited by 41 publications

(30 citation statements)

References 64 publications

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“…Erel-Goktepe and coworkers reported an ingenious and innovative approach to creating smart dual-functional surface coatings with both anti-adhesive and antibacterial agent releasing properties. They prepared monolayered films [119] as well as LbL self-assembled multilayer coatings [120] based on zwitterionic block copolymer micelles. Using a diblock copolymer composed of a polyzwitterionic poly[3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate] block (βPDMA) imparting anti-biofouling properties and a pH-responsive poly [2-(diisopropylamino)ethyl methacrylate] (PDPA) block, the authors attained pH-induced micellization by increasing the pH of an aqueous acidic solution of the βDMA-b-PDPA diblock copolymer above the pK a value of about 6.4 of the PDPA block.…”

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

“…Selective betainization of the DMA residues in the PDMA-b-PDPA diblock copolymer was achieved by treatment with 10 mol % excess (based on DMA residues) of 1,3-propane sultone at room temperature. Scheme 14 depicts the whole synthetic pathway used to prepare the βPDMA-b-PDPA diblock copolymer [119,120,123]. The diblock copolymer was dissolved in 1 mM NaH 2 PO 4 buffer at pH 3.0 to achieve a final concentration of 0.1-0.2 mg/mL.…”

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

“…The outcomes of these tests revealed the capacity of βPDMA-b-PDPA micellar monolayers to reduce biofilm formation by 45% and short-term adhesion of bacterial cells by up to 95% as compared to control unmodified substrates. Moreover, the authors prepared β-PDMA-b-PDPA micelles loaded with the hydrophobic antimicrobial agent triclosan [120]. First, triclosan was dissolved in ethanol at a concentration of 2.5 mg/mL and 1 mL of this solution was diluted 200-fold in a 1 mM NaH 2 PO 4 buffer at pH 3.0.…”

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

“…Furthermore, pH-triggered smart triclosan released from the multilayer films was achieved by dropping the environmental pH to 5.5. pH lowering results in gradual protonation of the amine groups in the hydrophobic PDPA core, which renders them hydrophilic, thereby causing disassembly of the micellar aggregates and release of the encapsulated triclosan. Since at infections sites, the surrounding milieu is slightly acidic, the authors concluded that besides their bacterial anti-adhesive properties, the pH-induced release of antibacterial agents is another important advantage of these mono and multilayered coatings [120].…”

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

“…The number of layers in the multilayered coatings was found to be of crucial importance for the anti-adhesive properties against S . aureus , the best results at physiological pH being obtained for a three-layer film configuration [ 120 ]. Three-layer films also displayed significant anti-adhesive properties at pH 7.5 against E .…”

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

See 4 more Smart Citations

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings

Balaure

Grumezescu

2020

Nanomaterials

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The second part of our review describing new achievements in the field of biofilm prevention and control, begins with a discussion of the active antibiofilm nanocoatings. We present the antibiofilm strategies based on antimicrobial agents that kill pathogens, inhibit their growth, or disrupt the molecular mechanisms of biofilm-associated increase in resistance and tolerance. These agents of various chemical structures act through a plethora of mechanisms targeting vital bacterial metabolic pathways or cellular structures like cell walls and cell membranes or interfering with the processes that underlie different stages of the biofilm life cycle. We illustrate the latter action mechanisms through inhibitors of the quorum sensing signaling pathway, inhibitors of cyclic-di-GMP signaling system, inhibitors of (p)ppGpp regulated stringent response, and disruptors of the biofilm extracellular polymeric substances matrix (EPS). Both main types of active antibiofilm surfaces, namely non-leaching or contact killing systems, which rely on the covalent immobilization of the antimicrobial agent on the surface of the coatings and drug-releasing systems in which the antimicrobial agent is physically entrapped in the bulk of the coatings, are presented, highlighting the advantages of each coating type in terms of antibacterial efficacy, biocompatibility, selective toxicity, as well as drawbacks and limitations. Developments regarding combined strategies that join in a unique platform, both passive and active elements are not omitted. In such platforms with dual functionality, passive and active strategies can be applied either simultaneously or sequentially. We especially emphasize those systems that can be reversely and repeatedly switched between the non-fouling status and the bacterial killing status, thereby allowing several bacteria-killing/surface regeneration cycles to be performed without significant loss of the initial bactericidal activity. Eventually, smart antibiofilm coatings that release their antimicrobial payload on demand, being activated by various triggers such as changes in local pH, temperature, or enzymatic triggers, are presented. Special emphasis is given to the most recent trend in the field of anti-infective surfaces, specifically smart self-defensive surfaces for which activation and switch to the bactericidal status are triggered by the pathogens themselves.

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Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

Section: Combining Active and Passive Antibiofilm Strategiesmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings

Balaure

Grumezescu

2020

Nanomaterials

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Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities

Liu

Ramakrishna

2021

Biotechnology Journal

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Background The success of biomedical implants in orthopedic and dental applications is usually limited due to insufficient bone‐implant integration, and implant‐related infections. Biointerfaces are critical in regulating their interactions and the desirable performance of biomaterials in biological environment. Surface engineering has been widely studied to realize better control of the interface interaction to further enhance the desired behavior of biomaterials. Purpose and Scope This review aims to investigate surface coating strategies in hard tissue applications to address insufficient osteointegration and implant‐related infection problems. Summary We first focused on surface coatings to enhance the osteointegration and biocompatibility of implants by emphasizing calcium phosphate‐related, nanoscale TiO2‐related, bioactive tantalum‐based and biomolecules incorporated coatings. Different coating strategies such as plasma spraying, biomimetic deposition, electrochemical anodization and LENS are discussed. We then discussed techniques to construct anti‐adhesive and bactericidal surface while emphasizing multifunctional surface coating techniques that combine potential osteointegration and antibacterial activities. The effects of nanotopography via TiO2 coatings on antibacterial performance are interesting and included. A smart bacteria‐responsive titanium dioxide nanotubes coating is also attractive and elaborated. Conclusion Developing multifunctional surface coatings combining osteogenesis and antimicrobial activity is the current trend. Surface engineering methods are usually combined to obtain hierarchical multiscale surface structures with better biofunctionalization outcomes.

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Impact of polymeric films and hydrogels: Physical characteristics on bacterial growth

Techakasikornpanich,

Jangpatarapongsa,

Polpanich

et al. 2024

Polymers for Advanced Techs

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Hydrogels find diverse applications in manipulating bacteria, and serving purposes like elevation, maintenance, and elimination. Several factors of hydrogel have been studied in the benefits of antibacterial activity. Factors such as hydrogel stiffness and roughness gain significance in surface coating, influencing bacterial behavior. However, the intricate interplay of hydrogel stiffness, roughness, polymer types, and bacterial species necessitates further exploration. The choice of polymer is dictated by the specific objectives, particularly in antibacterial scenarios where polymers with positive charge, hydrophilicity, and acidity prove effective. These properties induce robust electrostatic and hydrophobic/hydrophilic interactions, along with pH‐induced cell membrane damage, collectively contributing to hindered bacterial adhesion and growth. Additionally, extracellular polymeric substances (EPS) emerge as pivotal influencers in bacterial adhesion and proliferation. EPS production alters bacterial surfaces, fostering connections between bacteria and facilitating biofilm formation. The hydrophobic nature of EPS further complicates bacterial interactions with surface materials, emphasizing the nuanced interplay of hydrophilic and hydrophobic forces in bacterial adhesion. Herein, this work article has reviewed the related study of each physical property related to antibacterial property on the surface of the hydrogel. Moreover, this work also illustrates applications of the antibacterial properties of hydrogel for medical and surface treatment, including wound healing, food packaging, and surface coating. Additionally, the bacteria growing on hydrogel for engineered living materials, have been updated in various applications.

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Bacterial anti-adhesive and pH-induced antibacterial agent releasing ultra-thin films of zwitterionic copolymer micelles

Cited by 41 publications

References 64 publications

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings

Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities

Impact of polymeric films and hydrogels: Physical characteristics on bacterial growth

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