Bacterial Antibiotic Resistance: on the Cusp of a Post-antibiotic World

Sprigg, Kameron; Pietrangeli, Carolynn E.

doi:10.1007/s40506-019-0181-4

Cited by 11 publications

(5 citation statements)

References 73 publications

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“…Staphylococcus aureus is one of the most common foodborne pathogens; it contaminates various types of food and is absorbed directly into the bloodstream through the gastrointestinal tract, causing malignant heart tumours, vomiting and other symptoms that lead to food poisoning (Sprigg & Pietrangeli, 2019). The application of antimicrobial peptides combined with US can be used as a new method of food preservation to prevent foodborne diseases.…”

Section: Bioactive Propertiesmentioning

confidence: 99%

Research progress and latest application of ultrasonic treatment on protein extraction and modification

Zhang,

Ji,

Liang

et al. 2024

Int J of Food Sci Tech

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SummaryThe advancement of the modern food industry has prompted a shift away from traditional protein extraction methods due to their inherent limitations. As a result, there is a growing interest in exploring alternative methods for protein extraction and modification such as ultrasonic (US) treatment. This shift towards more sustainable and efficient protein extraction methods is a key research focus in obtaining safe proteins in an environmentally friendly manner. Furthermore, enhancing the functional properties of proteins through modification can expand their application. This paper reviews recent research progress and applications of US treatment on protein extraction and modification as well as the impact on protein structure and functional properties. In addition, the latest applications of ultrasound‐modified‐proteins, including nano‐proteins, 3D printing and interactions between proteins and other food components, are reviewed. This review may provide some inspiration for the potential application of US technologies in food fields.

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Section: Bioactive Propertiesmentioning

confidence: 99%

Research progress and latest application of ultrasonic treatment on protein extraction and modification

Zhang,

Ji,

Liang

et al. 2024

Int J of Food Sci Tech

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“…The massive use of antibiotics has led to the development of drug resistance or genetic mutations in pathogenic microorganisms, hence becoming resistant to drugs and posing a serious threat to human life and health. 179 On the other hand, anti-microbial drug development is at a bottleneck stage and therefore new methods to inactivate these microorganisms and their drug-resistant strains are urgently needed. aPDT is a new method to kill pathogenic microorganisms and their drug-resistant strains.…”

Section: Mof-mediated Synergism Of Reactive Oxygen Speciesmentioning

confidence: 99%

Metal–organic frameworks as a therapeutic strategy for lung diseases

et al. 2022

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“…Antibiotics are mainly used to cure various bacterial infections and diseases, but misuse and overdosage of antibiotics have led to several multidrug-resistant bacteria. Antibiotic resistance traits have spread widely, rendering antibiotics ineffective and posing major economic and health risks. , The spread and propagation of antibiotic resistance can be slowed down and even stopped with the rapid detection of resistant strains and by treatment with an effective dosage of the drug. Different conventional approaches such as disk diffusion, microdilution, and gradient disk diffusion methods were employed for the detection and assessment of antibiotic-sensitive and resistant microorganisms are time-consuming. , …”

Section: Introductionmentioning

confidence: 99%

Surface-Enhanced Raman Scattering (SERS) in Combination with PCA and PLS-DA for the Evaluation of Antibacterial Activity of 1-Isopentyl-3-pentyl-1H-imidazole-3-ium Bromide against Bacillus subtilis

Tahir,

Kamran,

Majeed

et al. 2024

ACS Omega

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In the current study, surface-enhanced Raman scattering (SERS) was performed to evaluate the antibacterial activity of lab-synthesized drug (1-isopentyl-3-pentyl-1H-imidazole-3-ium bromide salt) and commercial drug tinidazole againstBacillus subtilis. The changes in SERS spectral features were studied for unexposed bacillus and exposed one with various dosages of drug synthesized in the lab (1-isopentyl-3-pentyl-1H-imidazole-3-ium bromide salt), and SERS bands were assigned associated with the drug-induced biochemical alterations in bacteria. Multivariate data analysis tools including principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) have been utilized to analyze the antibacterial activity of the imidazole derivative (lab drug). PCA was employed in differentiating all the SERS spectral data sets associated with the various doses of the labsynthesized drug. There is clear discrimination among the spectral data sets of a bacterial strain treated with different concentrations of the drug, which are analyzed by PLS-DA with 86% area under the curve in receiver operating curve (ROC), 99% sensitivity, 100% accuracy, and 98% specificity. Various dominant spectral features are observed with a gradual increase in the different concentrations of the applied drug including 715, 850, 1002, 1132, 1237, 1396, 1416, and 1453 cm −1 , which indicate the possible biochemical changes caused in bacteria during the antibacterial activity of the lab-synthesized drug. Overall, the findings show that imidazole and imidazolium compounds generated from tinidazole with various alkyl lengths in the amide substitution can be effective antibacterial agents with low cytotoxicity in humans, and these results indicate the efficiency of SERS in pharmaceuticals and biomedical applications.

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Bacterial Antibiotic Resistance: on the Cusp of a Post-antibiotic World

Cited by 11 publications

References 73 publications

Research progress and latest application of ultrasonic treatment on protein extraction and modification

Research progress and latest application of ultrasonic treatment on protein extraction and modification

Metal–organic frameworks as a therapeutic strategy for lung diseases

Surface-Enhanced Raman Scattering (SERS) in Combination with PCA and PLS-DA for the Evaluation of Antibacterial Activity of 1-Isopentyl-3-pentyl-1H-imidazole-3-ium Bromide against Bacillus subtilis

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