Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Chadwick, Paul; Ousey, Karen

doi:10.12968/jowc.2019.28.6.370

Cited by 25 publications

(27 citation statements)

References 75 publications

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“…Considering therapies with low risk of generating microbial resistance, new products have been developed for the topical treatment of wounds, with the objective of promoting the interruption of the initial adhesion process of microorganisms to the wound bed, among these, the DACC stands out, a fatty acid derivative that acts as a passive antibacterial, in order to sequester the bacteria into the dressing through hydrophobic bonds on the microorganism's extracellular surface, promoting irreversible adherence to the DACC substrate [12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

Use of Dialkyl Carbamoyl Chloride in the Prevention and Treatment of Biofilm in Wounds

Freitas

Rezende

Silva

et al. 2021

ESTIMA, Braz. J. Enterostomal Ther.

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Objectives: The aim was to identify the benefits of using Dialkyl Carbamoyl Chloride for the treatment of biofilms in wounds. Methods: This is an integrative literature review that aimed to answer the guiding question: “What are the benefits of using Dialkyl Carbamoyl Chloride in the healing of skin lesions?”. The article selection stages resulted in 13 articles included. Results: The selected articles were grouped into two groups, namely: prevention and treatment of infection in wounds and prevention of surgical site infection, with nine productions in the first group and four in the second. Studies have shown that Dialkyl Carbamoyl Chloride attenuates colonization symptoms, such as odor, pain complaints and oozing, in addition to aiding in the prophylactic management of wound biofilm. Evidence indicates that dressings with Dialkyl Carbamoyl Chloride have no adverse effects, making them viable and safe options for chronic, acute and, mainly, infected injuries. Conclusion: It was identified that Dialkyl Carbamoyl Chloride was able to promote beneficial actions in the treatment of wounds, especially those of greater complexity. The proper choice of dressings and coverings can contribute to the rational use of existing technologies and antimicrobials, culminating in cost reduction and promotion of quality of life for individuals with chronic wounds.

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Section: Discussionmentioning

confidence: 99%

Use of Dialkyl Carbamoyl Chloride in the Prevention and Treatment of Biofilm in Wounds

Freitas

Rezende

Silva

et al. 2021

ESTIMA, Braz. J. Enterostomal Ther.

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“…Considerando terapias com baixo risco de gerar resistência microbiana, novos produtos vêm sendo desenvolvidos para tratamento tópico das feridas, com o objetivo de promover a interrupção do processo de adesão inicial dos microrganismos ao leito da lesão, dentre esses, destaca-se o DACC, um derivado de ácido graxo que age como antibacteriano passivo, de modo a sequestrar a bactéria para dentro do curativo por meio de ligações hidrofóbicas da superfície extracelular do microrganismo, promovendo aderência irreversivel ao substrato do DACC [12][13][14] .…”

Section: Discussionunclassified

Utilização Do Cloreto De Dialquil Carbamoil Na Prevenção E Tratamento De Biofilme Em Feridas

Silva

Vieira

Moraes

et al. 2021

ESTIMA, Braz. J. Enterostomal Ther.

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Objetivos:Objetivou-se identificar os benefícios na utilização do Cloreto de Dialquil Carbamoil para tratamento de biofilmes em feridas. Métodos:Trata-se de uma revisão integrativa de literatura que visou responder à questão norteadora: “Quais os benefícios do uso de Cloreto de Dialquil Carbamoil na cicatrização de lesões de pele?”. As etapas de seleção dos artigos resultaram em 13 artigos inclusos. Resultados: Os artigos selecionados foram agrupados em dois grupos, a saber: prevenção e tratamento de infecção em feridas e prevenção de infecção de sítio cirúrgico, sendo nove produções no primeiro grupo e quatro no segundo. Os estudos demonstraram que o Cloreto de Dialquil Carbamoil atenua os sintomas de colonização, como odor, queixas álgicas e exsudação, além disso, auxilia no gerenciamento profilático do biofilme da ferida. As evidências apontam que coberturas com Cloreto de Dialquil Carbamoil não possuem efeitos adversos, tornando-se opções viáveis e seguras para lesões crônicas, agudas e, principalmente, infectadas. Conclusão: Identificou-se que o Cloreto de Dialquil Carbamoil foi capaz de promover ações benéficas ao tratamento de feridas, especialmente as de maior complexidade. A escolha adequada das coberturas e dos curativos pode contribuir com a utilização racional das tecnologias existentes e dos antimicrobianos, culminando em redução de custos e promoção de qualidade de vida aos indivíduos com feridas crônicas.

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“…With particular regards to wound healing, this condition may develop due to the chronic state of inflammation of the wound that could make the tissue more prone to the entrance of bacteria and to biofilm formation (see Fig. 2) [65,66], thus making the use of dressings a valuable option to counteract it [48]. Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Streptacoccus mutans infections may develop, instead, after the application of dental membranes [7].…”

Section: Mesh-related Complicationsmentioning

confidence: 99%

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

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Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effective and enhanced treatment is crucial to ameliorate patients’ living conditions both from medical and aesthetic points of view. At present, non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor dysfunctions and guided bone regeneration, with polypropylene and poly tetrafluoroethylene being the most common. Biological prostheses, such as surgical grafts, have been employed mainly for breast plastic surgery and wound healing applications. Despite the advantages of mesh implants to the treatment of these conditions, there are still many drawbacks, mainly related to the arising of a huge number of post-operative complications, among which infections are the most common. Developing a mesh that could appropriately integrate with the native tissue, promote its healing and constructive remodelling, is the key aim of ongoing research in the area of surgical mesh implants. To this end, the adoption of new biomaterials including absorbable and natural polymers, the use of drugs and advanced manufacturing technologies, such as 3D printing and electrospinning, are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice. The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes, the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations. Graphic abstract

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Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Cited by 25 publications

References 75 publications

Use of Dialkyl Carbamoyl Chloride in the Prevention and Treatment of Biofilm in Wounds

Use of Dialkyl Carbamoyl Chloride in the Prevention and Treatment of Biofilm in Wounds

Utilização Do Cloreto De Dialquil Carbamoil Na Prevenção E Tratamento De Biofilme Em Feridas

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

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