Bacterial biofilm formation on urologic devices and heparin coating as preventive strategy

Tenke, Péter; Riedl, Claus R.; Jones, G. L.; Williams, Gareth; Stickler, D.J.; Nagy, Elisabeth

doi:10.1016/j.ijantimicag.2003.12.007

Cited by 138 publications

(87 citation statements)

References 35 publications

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“…The effect of surface coatings containing heparin on bacterial adhesion and biofilm formation is unclear. Some reports show a decreased rate of infection while other reports show no antibiotic effect of surface attached heparin [139][140][141][142]. The mechanism, by which heparin coatings decrease bacterial colonization, may be indirect.…”

Section: Blood Compatibility Of Silver Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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Section: Blood Compatibility Of Silver Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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“…Gümüş kaplı kateter kullanıldığında üriner infeksiyon gelişme oranı %30'luk bir azalma göstermiştir (26) . Heparinle kaplanmış kateterler ile tıkanıklığın ve biyofilm oluşumunun engellenebileceği gösterilmiştir (27) . Nitrofurazon kaplı kateterlerin üriner infeksiyon gelişmesi üzerine etkilerinin araştırıldığı çalışmalarda kısa süreli kateterizasyonda enfeksiyon oranlarının düştüğü fakat uzun süreli kateterizasyonda fark görülme-diği bildirilmiştir (28) .…”

Section: Discussionunclassified

Investigation of Biofilm Formation of ESBL Positive Uropathogenic Escherichia coli Isolates on (Microplate) Surfaces Modified with Plasma Polymerization Technique and Nanomaterials: An Experimental Model

Hortaç¹,

Kaleli²,

Çökeliler³

et al. 2016

TMCD

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“…Therefore, one antimicrobial strategy might be to develop therapies to disrupt the multicellular structure of the biofilm. It could be that host defences might be able to resolve the infection once the multicellularity of the biofilm is reduced, and then the effectiveness of antibiotics might be restored [42] showed that on heparin-coated catheter, stents, no biofilm formation was evident between 6 and 8 weeks, whereas uncoated tubes were obstructed within 2-3 weeks [46]. In case of IMD in non surgical patients, long term antibiotics therapy is requisite.…”

Section: Management Of Biofilm Infectionmentioning

confidence: 99%

Bacterial Biofilms: A Confrontation to Medical Science

2017

IJSR

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Biofilms is a consortia of microorganisms in which microorganism adhere to a substratum in an irreversible manner and are enclosed in self -produced matrix of extracellular polymeric substance. Common example of biofilm are dental plaque, device associated infection. Mostly biofilms are infective in nature and can be a source of Nosocomial infection. According to a report published by national institute of Health about 65% of all microbial infections and 80% of all chronic infections are associated with biofilms. The structural anatomy of biofilms protects microbial cells from antimicrobial agents, UV rays. These biofilms act as a barrier; antibiotics cannot reach to these microbes hindering the killing of the microbes thus posing a serious threat to public health. Management of these bacterial biofilms requires an early detection method and development of novel and efficient control measures for treating patients improving patient care and timely management.

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Bacterial biofilm formation on urologic devices and heparin coating as preventive strategy

Cited by 138 publications

References 35 publications

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Investigation of Biofilm Formation of ESBL Positive Uropathogenic Escherichia coli Isolates on (Microplate) Surfaces Modified with Plasma Polymerization Technique and Nanomaterials: An Experimental Model

Bacterial Biofilms: A Confrontation to Medical Science

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