Bacterial biofilms and chronic rhinosinusitis

Madeo, Jennifer; Frieri, Marianne

doi:10.2500/aap.2013.34.3665

Cited by 33 publications

(26 citation statements)

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“…29 There are studies that looked at the role of S. aureus in the pathogenesis of CRS with inconclusive findings. 30,31 Although some of the studies within this review revealed an increase of S. aureus, it seems unlikely that S. aureus is the causative agent of the persistent inflammation in patients with CRS. However, the true role of this organism in CRS remains unclear.…”

Section: Discussionmentioning

confidence: 94%

A Systematic Review of the Sinonasal Microbiome in Chronic Rhinosinusitis

Anderson

Stokken

Sanford

et al. 2016

Am J Rhinol�Allergy

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Section: Discussionmentioning

confidence: 94%

A Systematic Review of the Sinonasal Microbiome in Chronic Rhinosinusitis

Anderson

Stokken

Sanford

et al. 2016

Am J Rhinol�Allergy

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“…10 CRS is a highly prevalent disease in the adult and pediatric populations, and causes significant burden, and the management is considered one of the most costly public health conditions; comorbidities include asthma, aspirin sensitivity, and nasal polyposis. 11 Staphylococcus aureus biofilms and exotoxins that act as superantigens have been implicated as playing an important pathologic role in the incidence, maintenance, and ongoing burden of CRS. A better understanding of the interplay between bacterial factors, host factors, and the environment will facilitate better management of this disease.…”

Section: Epidemiologymentioning

confidence: 99%

Review: Immunology of Sinusitis, Trauma, Asthma, and Sepsis

Frieri¹,

Kumar

Boutin

2015

Allergy�Rhinol (Providence)

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Background:This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis, elderly pathogenesis, oxidative stress, depression, seasonal variation, vitamin D, genetic susceptibility and sepsis, hereditary angioedema related to trauma and stress.Objective:The objective of this review is to link chronic rhinosinusitis, epidemiology, innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma and sinusitis.Methods:A literature search was conducted from several articles, prospective studies, recent reviews and earlier reports. A synergistic relationship develops between activation of the innate immune system and the loss of organ barrier functions. Many complex factors, such as genetics, physical agents, mediators in the development of organ failure both in asthma, sinusitis, stress, depression and trauma, leading to posttraumatic organ failure. Asthma and sepsis, a common condition encountered in hospital environments remains an important cause of death at intensive care units where allergists/immunologists and otolaryngologists are frequently consulted. The patient's immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a proinflammatory mediator release with inappropriate activation.Conclusion:This review discussed chronic rhinosinusitis, sinusitis related to trauma, the innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, inflammation, reactive oxygen species, asthma pathogenesis, and asthma in the elderly, oxidative stress, depression, seasonal variation and vitamin D, cytokines, genetic susceptibility related to sepsis, hereditary angioedema related to trauma and stress.

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“…Inflammation and biofilm infection have been implicated in the pathophysiology of CRS (Fokkens et al, 2012;Madeo and Frieri, 2013). Bacterial biofilms are a complex community of bacteria that form on both biotic and abiotic surfaces contained in a hydrated polymeric matrix (Costerton, Stewart, and Greenberg, 1999;Smith, Buchinsky, and Post, 2011).…”

Section: Discussionmentioning

confidence: 98%

A randomized clinical trial comparing pulsed ultrasound and erythromycin phonophoresis in the treatment of patients with chronic rhinosinusitis

Ansari

Naghdi

Fathali

et al. 2014

Physiotherapy Theory and Practice

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Therapeutic ultrasound, an important physiotherapy modality, has been used successfully in the treatment of patients with chronic rhinosinusitis (CRS). No study has compared pulsed ultrasound (PUS) with erythromycin phonophoresis (EP). The aim of this randomized, double-blind, parallel group study with concealed allocation was to compare PUS with EP. Sixty CRS patients were randomly allocated into two groups. Group 1 had PUS and Group 2 had EP. Patients were treated 3 days a week for 10 sessions over 4 weeks. The severity of nine CRS symptoms was self-rated by patients on an ordinal scale of 0-3 (absent, mild, moderate or severe) at baseline and after the 10th treatment session. Individual symptom scores were summed to obtain a "Total Symptom Score" (TSS). The outcome measure included percentage improvement in the TSS. A statistically significant improvement in TSS occurred with both PUS and EP therapy groups (p < 0.05). The percentage improvement in the EP group was statistically greater than in the PUS group (67.2 versus 49.3%) (p = 0.03). The effect sizes in both therapy groups were large; PUS: d = 1.36 and EP: d = 2.15. EP was found to be superior over PUS therapy.

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Bacterial biofilms and chronic rhinosinusitis

Cited by 33 publications

References 0 publications

A Systematic Review of the Sinonasal Microbiome in Chronic Rhinosinusitis

A Systematic Review of the Sinonasal Microbiome in Chronic Rhinosinusitis

Review: Immunology of Sinusitis, Trauma, Asthma, and Sepsis

A randomized clinical trial comparing pulsed ultrasound and erythromycin phonophoresis in the treatment of patients with chronic rhinosinusitis

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