Bacterial biofilms: their role in chronical infection processes and the means to combat them

Ilyina, T. S.; Romanova, Yu. M.

doi:10.17116/molgen20213902114

Cited by 13 publications

(1 citation statement)

References 85 publications

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“…Bacterial biofilms can form anywhere, including on medical instruments such as catheters and implants [ 1 , 3 ]. Biofilms are responsible for the majority of chronic infections, which are mainly associated with the use of medical implantable equipment [ 4 , 5 , 6 ], and do not respond to antibiotic treatment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Laser-Induced Transferred Antibacterial Nanoparticles for Mixed-Species Bacteria Biofilm Inactivation

et al. 2023

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In the present study, copper and silver nanoparticles with a concentration of 20 µg/cm2 were synthesized using the method of laser-induced forward transfer (LIFT). The antibacterial activity of the nanoparticles was tested against bacterial biofilms that are common in nature, formed by several types of microorganisms (mixed-species bacteria biofilms): Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The Cu nanoparticles showed complete inhibition of the bacteria biofilms used. In the course of the work, a high level of antibacterial activity was demonstrated by nanoparticles. This activity manifested in the complete suppression of the daily biofilm, with the number of bacteria decreasing by 5–8 orders of magnitude from the initial concentration. To confirm antibacterial activity, and determine reductions in cell viability, the Live/Dead Bacterial Viability Kit was used. FTIR spectroscopy revealed that after Cu NP treatment, there was in a slight shift in the region, which corresponded to fatty acids, indicating a decrease in the relative motional freedom of molecules.

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Section: Introductionmentioning

confidence: 99%

Laser-Induced Transferred Antibacterial Nanoparticles for Mixed-Species Bacteria Biofilm Inactivation

et al. 2023

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Nitrosonium cation NO+ inhibits nitric oxide (NO) functions in biofilm production with pathogenic Pseudomonas aeruginosa in vitro

Vasilieva¹,

Romanova²,

Vanin³

2023

Mol. genet. mikrobiol. virusol.

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Bacterial vaginosis biofilms: a target for therapeutic innovation

Rossolovskaya,

Trifonova,

Gadaeva

et al. 2024

V.F.Snegirev Archives of Obstetrics and Gynecology

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Bacterial vaginosis (BV) is one of the most common variants of vaginal microbiome disorders worldwide. Bacterial vaginosis is a risk factor for the development of various complications in obstetric and gynecologic practice. Despite many years of study of this syndrome, existing and dynamically improving clinical, laboratory and instrumental diagnostic methods, progressive development of science in general, the etiology and pathogenesis of BV are still poorly understood. This is evidenced by the high frequency of chronic and/or recurrent course. There are standard therapeutic approaches aimed at eradication of the etiologic agent, but the level of efficacy remains questionable due to recurrent episodes, which requires further study of this problem. At present, it is reliably established that G. vaginalis forms polymicrobial biofilms on the mucosa of the urogenital tract. Biofilm is a cooperation of microorganisms that are attached to the surface of the epithelium and bound together by a polymeric matrix. Biofilm influences the properties of microorganisms included in its structure, provides conditions for their interaction. This leads not only to the strengthening of already existing pathogenic properties of bacteria associated with bacterial vaginosis, but also to the formation of new characteristics, due to which microorganisms become less susceptible to previously effective antibacterial drugs and aggressive environments, which contributes to recurrence. In most cases, treatment of BV is carried out by a direct mechanism of action on microorganisms, but in patients with verified “biofilm” bacterial vaginosis such strategy is not effective, which leads to recurrences. Thus, diagnostics of the causes of recurrent BV, development and introduction into clinical practice of antibiofilm agents aimed at destruction of the biofilm matrix and release of bacteria from its structure, which will increase the effectiveness of treatment, remain topical today.

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Bacterial biofilms: their role in chronical infection processes and the means to combat them

Cited by 13 publications

References 85 publications

Laser-Induced Transferred Antibacterial Nanoparticles for Mixed-Species Bacteria Biofilm Inactivation

Laser-Induced Transferred Antibacterial Nanoparticles for Mixed-Species Bacteria Biofilm Inactivation

Nitrosonium cation NO+ inhibits nitric oxide (NO) functions in biofilm production with pathogenic Pseudomonas aeruginosa in vitro

Bacterial vaginosis biofilms: a target for therapeutic innovation

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