1996
DOI: 10.1093/jac/37.6.1047
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Bacterial biofllms: resistance to antimicrobial agents

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Cited by 63 publications
(48 citation statements)
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“…It is thought that the formation of the glycocalyx serves as an integral matrix for a biofilm and that following the adhesion of bacteria to a substrate, the glycocalyx forms a protective milieu for cell division and microcolony formation and growth (7,11). Some studies propose that the glycocalyx either acts as a diffusion barrier or, by complexing antibacterial agents, excludes and/or influences the penetration of antimicrobial agents to the underlying cells (10,13). Modern medicine increasingly relies on the use of indwelling medical devices such as catheters and prosthetic joints for multiple purposes.…”
Section: Resultsmentioning
confidence: 99%
“…It is thought that the formation of the glycocalyx serves as an integral matrix for a biofilm and that following the adhesion of bacteria to a substrate, the glycocalyx forms a protective milieu for cell division and microcolony formation and growth (7,11). Some studies propose that the glycocalyx either acts as a diffusion barrier or, by complexing antibacterial agents, excludes and/or influences the penetration of antimicrobial agents to the underlying cells (10,13). Modern medicine increasingly relies on the use of indwelling medical devices such as catheters and prosthetic joints for multiple purposes.…”
Section: Resultsmentioning
confidence: 99%
“…Surface association allows the organisms to persist in a favourable environment, while the biofilm structure protects cells from dehydration and other environmental pressures (Donlan & Costerton, 2002). Biofilms can form on almost any biological or abiotic surface and generally have susceptibilities towards antibiotics and biocides that are 100-1000-fold less than equivalent populations of planktonic bacteria (Gander, 1996;Gilbert et al, 2002;O'Toole, 2002). Biofilms have an enormous impact on healthcare, and are estimated to be associated with 65 % of nosocomial infections (Potera, 1999).…”
Section: Introductionmentioning
confidence: 99%
“…The pathogenesis of P. aeruginosa is mediated by secreted virulence factors, which include toxins, such as pyocyanin, pyoverdine, siderophores, and hydrogen cyanide (12,13), as well as by bacterial enzymes, such as elastase and alkaline protease (14). Moreover, biofilm formation protects the bacteria from adverse environmental factors and increases their antibiotic resistance and pathogenesis (15). Interestingly, the virulence factors and biofilm formation were found to be regulated by quorum centration in each plate to prevent egg hatching.…”
mentioning
confidence: 99%