Bacterial cellulose-based composites as vehicles for dermal and transdermal drug delivery: A review

Mohammadi, Sajad; Jabbari, Farzaneh; Babaeipour, Valiollah

doi:10.1016/j.ijbiomac.2023.124955

Cited by 17 publications

(7 citation statements)

References 148 publications

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“…Although BC displays many beneficial properties, it is an unsuitable biomaterial for controlled drug delivery due to the failure to resist the freedom of movement of small molecules in the highly porous structure of BC (Mohammadi et al, 2023). Therefore, modification of BC has become inevitable to develop its properties for desired application in drug delivery.…”

Section: Modifications Of Bcmentioning

confidence: 99%

Advances in drug delivery applications of modified bacterial cellulose-based materials

Liang

2023

Front. Bioeng. Biotechnol.

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Bacterial cellulose (BC) is generated by certain species of bacteria and comprises polysaccharides with unique physical, chemical, and mechanical characteristics. Due to its outstanding biocompatibility, high purity, excellent mechanical strength, high water absorption, and highly porous structure, bacterial cellulose has been recently investigated for biomedical application. However, the pure form of bacterial cellulose is hardly used as a biomedical material due to some of its inherent shortcomings. To extend its applications in drug delivery, modifications of native bacterial cellulose are widely used to improve its properties. Usually, bacterial cellulose modifications can be carried out by physical, chemical, and biological methods. In this review, a brief introduction to bacterial cellulose and its production and fabrication is first given, followed by up-to-date and in-depth discussions of modification. Finally, we focus on the potential applications of bacterial cellulose as a drug delivery system.

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Section: Modifications Of Bcmentioning

confidence: 99%

Advances in drug delivery applications of modified bacterial cellulose-based materials

Liang

2023

Front. Bioeng. Biotechnol.

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“…To date, BC has primarily been used in the drug delivery field for transdermal applications, where BC films are prepared for use in antimicrobial wound healing and dressing, and face and eye masks for anti-aging and scarred skin rejuvenation. 20–22 Spherical BC particles with diameters in the 0.5–1.0 mm range have also previously been reported to enable a controlled drug release and exhibit antibacterial properties for tissue engineering and drug delivery applications. 8,16,22–25 Despite the drug delivery potential demonstrated by BC microparticles, their application for long-circulation times and deep tissue penetration is limited due to their size.…”

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose nanoparticles as a sustainable drug delivery platform for protein-based therapeutics

Balistreri,

Campbell,

et al. 2024

RSC Appl. Polym.

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“…Nanocellulose with good biocompatibility, hydrophilicity, and non-toxicity can be applied in humid environments. 8 Mao et al synthesized an in-situ bacterial cellulose/gelatin hydrogel loaded with selenium nanoparticles (BC/Gel/SeNPs), which had saturated solubility up to around 2000% and could be completely degraded in 180 min under the catalysis of cellulase. The loading of nanoparticles resulted in significant antioxidant and antimicrobial capacity.…”

Section: Introductionmentioning

confidence: 99%

Design and Self-Assembly of Peptide-Copolymer Conjugates into Nanoparticle Hydrogel for Wound Healing in Diabetes

Lin,

Zhang,

Cai

et al. 2024

IJN

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Background Delayed wound healing in skin injuries has become a significant problem in clinics, seriously affecting and even threatening life and health. Recently, research interest has increased in developing wound dressings containing bioactive compounds capable of improving outcomes for complex healing needs. Methods In this study, Puerarin -loaded nanoparticles (Pue-NPs) were prepared using the cell-penetrating peptide-poly (lactic-co-glycolic acid) (CPP-PLGA) as a drug carrier by the emulsified solvent evaporation method. Then, they were added into poly (acrylic acid) to obtain a self-assembled nanocomposite hydrogels (SANHs) drug delivery system using the co-polymerization method. The particle size, zeta potential, and micromorphology of Pue-NPs were measured; the appearance, mechanical properties, adhesive strength, and biological activity of SANHs were performed. Finally, the potential of SANHs for wound healing was further evaluated in streptozotocin-induced diabetic mice. Results Pue-NPs were regularly spherical, with an average particle size of 134.57 ± 1.42 nm and a zeta potential of 2.14 ± 0.78 mV. SANHs was colorless and transparent with a honeycomb-like porous structure and had an excellent swelling ratio (917%), water vapor transmission rate (3077 g·m −2 ·day −1 ), mechanical properties (Young’s modulus of 18 kPa, elongation at break of 307%), and adhesive strength (15.5 kPa). SANHs exhibited sustained release of Pue over 48h, with a cumulative release of 55.60 ± 6.01%. In vitro tests revealed that the SANHs presented a 92.22% antibacterial rate against Escherichia coli after 4h, and a 61.91% scavenging rate of 1.1-diphenyl-2-trinitrophenylhydrazine (DPPH) radical. In vivo experiments showed that SANHs accelerated wound repair by reducing the inflammatory response at the wound site, promoting angiogenesis, and facilitating epidermal regeneration and collagen deposition. Conclusion In conclusion, we successfully prepared SANHs. Our results show that SANHs have excellent performance and improves wound healing in diabetic mice model, indicating that it can be used to develop an effective strategy for the treatment of diabetic wounds.

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Bacterial cellulose-based composites as vehicles for dermal and transdermal drug delivery: A review

Cited by 17 publications

References 148 publications

Advances in drug delivery applications of modified bacterial cellulose-based materials

Advances in drug delivery applications of modified bacterial cellulose-based materials

Bacterial cellulose nanoparticles as a sustainable drug delivery platform for protein-based therapeutics

Design and Self-Assembly of Peptide-Copolymer Conjugates into Nanoparticle Hydrogel for Wound Healing in Diabetes

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