Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing

Deng, Lili; Huang, Yinjun; Chen, Shiyan; Han, Zhiliang; Han, Zhengzhe; Jin, Mengtian; Qu, Xiangyang; Wang, Baoxiu; Wang, Huaping; Gu, Song

doi:10.1016/j.carbpol.2023.120647

Cited by 52 publications

(24 citation statements)

References 49 publications

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“…The switch release and drug release kinetics of the drug can be controlled by light intensity, which has great potential in the local drug release for tumor treatment (Figure 2b, 2c). Deng et al [36] developed a three-dimensional networked cellulose-based hydrogel (BC/PDA/ZIF-8/Ag) loaded with silver zeolite imidazole framework (ZIF-8) for a stable release of antibacterial agents Ag + and Zn 2 + under nearinfrared (NIR) irradiation. The surface temperature of the hydrogel can reach 50 °C in just 5 minutes under NIR (Figure 2d, 2e).…”

Section: Near-infrared Light Sourcementioning

confidence: 99%

Photothermal Conversion of Hydrogel‐Based Biomaterial

Wei

et al. 2023

The Chemical Record

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Traditional energy from fossil fuels like petroleum and coal is limited and contributes to global environmental pollution and climate change. Developing sustainable and eco‐friendly energy is crucial for addressing significant challenges such as climate change, energy dilemma and achieving the long‐term development of human society. Biomass hydrogels, which are easily synthesized and modified, have diverse sources and can be designed for different applications. They are being extensively researched for their applications in artificial intelligence, flexible sensing, biomedicine, and food packaging. The article summarizes recent advances in the preparation and applications of biomass‐based photothermal conversion hydrogels, discussing the light source, photothermal agents, matrix, and preparation methods in detail. It also explores the use of these hydrogels in seawater desalination, photothermal therapy, antibacterial agents, and light‐activated materials, offering new ideas for developing sustainable, efficient, and advanced photothermal conversion biomass hydrogel materials. The article concludes with suggestions for future research, highlighting the challenges and prospects in this field and paving the way for developing of long‐lasting, efficient energy materials.

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Section: Near-infrared Light Sourcementioning

confidence: 99%

Photothermal Conversion of Hydrogel‐Based Biomaterial

Wei

et al. 2023

The Chemical Record

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“…[20] To this regard, the use of hydrogels as delivery vehicles for antimicrobial species is highly desirable, [21] with the possibility to provide added value by conferring antimicrobial activity to the dressing surface. [22] Here, we aimed to combine Chitosan (CS), Graphene Oxide (GO) and Rose Bengal (RB) for the preparation of hybrid hydrogel membrane as delivery vehicles for the electric responsive release of antimicrobial species. The novelty of our approach is the set-up of a highly reproducible single step reaction consisting in tripolyphosphate (TPP)-based ionic gelation, to prepare a biodegradable hydrogel consisting of multiple components with tailored activities: 1) CS acts as the biocompatible and biodegradable element with high water retention capability; [23] 2) GO acts as antimicrobial surface, enhances the drug loading capability making the release profile prolonged over time and allows the modulation by an external voltage; [24,25] TPP, a non-toxic polyanion able to crosslink CS chains, is widely recognized as a safe (GRAS 582.6810) reactant by the Food and Drug Administration; [26] and 3) RB is used as a model for bioactive molecules with antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Luca

Poursani

Curcio

et al. 2023

Macro Materials & Eng

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With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC‐5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g−1 for blank and hybrid hydrogels, respectively) and an electro‐responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin‐resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB.

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“…Currently, wound dressing is the most commonly applied approach to treat skin injuries. , An ideal wound dressing should possess several advantages, including mechanical strength, antibacterial activity, anti-inflammatory activity, biocompatibility, biodegradability, and cost-effectiveness. − Various types of materials have been developed as wound dressings, including foams, films, nanofibers, sponges, hydrogels, and functional gauze. Among these options, natural polymer-based hydrogels have garnered increasing attention due to their excellent biocompatibility, ease of removal, and ability to maintain a physiologically moist microenvironment at the wound site. , Cellulose, chitosan, hyaluronic acid, collagen, silk fibroin (SF), alginate, gelatin, and many other natural polymers have been studied to fabricate hydrogel dressings through solvent casting, physical/chemical cross-linking, 3D printing, and self-assembly. , …”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Yan,

Li,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Excessive oxidative stress, bacterial infections, and inflammation are the primary factors impeding the healing of skin wounds. Bioactive hydrogels are commonly employed in the treatment of skin injuries. However, the limited solubility of many drugs and active agents in water significantly hampers their effectiveness in hydrogel dressings. In this research, prior to incorporation into the silk fibroin (SF) hydrogel matrix, two active agents curcumin and silver nanoparticles (Ag NPs) were decorated by silk sericin to improve their dispersibility and stability in water. The resultant SF/Ag/C hydrogels combined the biological safety and nontoxicity of SF, the antioxidant and anti-inflammatory efficacy of curcumin, and the antibacterial effect of Ag NPs. These properties effectively enhanced wound repair by reducing bacterial infections, mitigating oxidative stress, suppressing the expression of pro-inflammatory factors, and promoting angiogenesis. This study presented a straightforward approach for constructing bioactive hydrogels for the promotion of the wound healing process.

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Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing

Cited by 52 publications

References 49 publications

Photothermal Conversion of Hydrogel‐Based Biomaterial

Photothermal Conversion of Hydrogel‐Based Biomaterial

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

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