Bacterial cellulose to reinforce urethrovesical anastomosis. A translational study

Maia, Guilherme Tavares da Silva; Albuquerque, Amanda Vasconcelos de; Filho, Euclides Dias Martins; Neto, Filipe Tenório de Lira; Souza, Veridiana Sales Barbosa de; Silva, Anderson Arnaldo da; Lira, Mariana Montenegro de Melo; Lima, Salvador Vilar Correia

doi:10.1590/s0102-865020180080000003

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…Colonic, buccal and lingual mucosa are usually used, but complications like swelling, pain, and limitations of the mouth opening have been reported (Huang et al 2015). Tissue engineering technology may provide an alternative, and recent experimental and clinical studies have shown an encouraging performance of the BC membrane in uretroplasty (Maia et al 2018).…”

Section: Soft Tissue Engineeringmentioning

confidence: 99%

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

et al. 2019

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Tissue engineering promotes tissue regeneration through biomaterials that have excellent properties and have the potential to replace tissues. Many studies show that bacterial cellulose (BC) might ensure tissue regeneration and substitution, being used for the bioengineering of hard, cartilaginous and soft tissues. Bacterial cellulose is extensively used as wound dressing material and results show that BC is a promising tissue scaffold (bone, cardiovascular, urinary tissue). It can be combined with polymeric and non-polymeric compounds to acquire antimicrobial, cell-adhesion and proliferation properties. To ensure proper tissue regeneration, the material has to be: biocompatible, with minimum tissue reaction and biodegradability; bio-absorbable, to promote tissue development, cellular interaction and grow; resistant to support the weight of the newly formed tissue. Its versatile structure, physical and biochemical properties can be adjusted by adapting the bacteria culturing conditions. The main biomedical applications seem to be as hard (bone, dental), fibrocartilaginous (meniscal) and soft tissue (skin, cardiovascular, urinary) substituents. This paper reviews the current state of knowledge, challenges and future applications of BC and its biomedical potential in veterinary medicine. It was focused on the main uses in regeneration and scaffold tissue replacement and, although BC showed promising results, there is a lack of successful results of BC use in clinical practice. Most studies were performed only at experimental level and further research is needed for BC to enter clinical veterinary practice.

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Section: Soft Tissue Engineeringmentioning

confidence: 99%

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

et al. 2019

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“…Rat [17], dog [18], and pig models were also established even the complex FIA [19], but no mouse model was established up to now. Rabbits are a good animal model for fistula research, which has been used to establish a model of transsphincteric fistula [20], aortocavitary fistula [21], esophageal anastomotic fistula [22], urinary fistula [23], and perianal fistula [24]. Rabbits have suitable body size, are easy to obtain, and can establish a large number of FIA models at a time; using this model can improve the therapeutic schedule.…”

Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit

Qin

Wang

Huang

et al. 2019

Stem Cells International

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Fistula-in-ano (FIA, anal fistula) treatment remains a surgical challenge for coloproctologists. Adipose tissue-derived stem cells (ADSCs) are a new frontier in the treatment of FIA. In this study, we established a FIA model of Japanese rabbit and evaluated the effect of four treatments on fistula healing: ADSC transplantation, acellular small intestinal submucosa (ASIS), noncutting seton, and PBS as negative control. High-throughput RNA sequencing was also performed to investigate the anal tissue (normal and ADSC treatment group) expression profile of mRNA. Our data showed that ADSC treatment had the shortest time to promote fistula healing compared to the other treatments, and fistula filled with new adipose tissue and muscle cells without scar. Gene Ontology (GO) analysis of RNA-seq data showed that the differential genes are enriched in system development and animal organ development. Taken together, our findings demonstrate that ADSCs rapidly promote fistula healing through differentiation, a promising stem cell therapy for FIA. The rabbit is an effective animal model for evaluating FIA therapeutic options.

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“…The results showed that the BC membrane was well integrated into the urethral wall, promoting tissue remodeling. In another report, Maia et al also used a BC membrane as a urethral reinforcement for ureterovesical anastomosis in rabbit models [ 112 ]. The results conclude that there was a decrease in wall thickness after 14 weeks of implantation.…”

Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

et al. 2022

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The sharp increase in the use of cellulose seems to be in increasing demand in wood; much more research related to sustainable or alternative materials is necessary as a lot of the arable land and natural resources use is unsustainable. In accordance, attention has focused on bacterial cellulose as a new functional material. It possesses a three-dimensional, gelatinous structure consisting of cellulose with mechanical and thermal properties. Moreover, while a plant-originated cellulose is composed of cellulose, hemi-cellulose, and lignin, bacterial cellulose attributable to the composition of a pure cellulose nanofiber mesh spun is not necessary in the elimination of other components. Moreover, due to its hydrophilic nature caused by binding water, consequently being a hydrogel as well as biocompatibility, it has only not only used in medical fields including artificial skin, cartilage, vessel, and wound dressing, but also in delivery; some products have even been commercialized. In addition, it is widely used in various technologies including food, paper, textile, electronic and electrical applications, and is being considered as a highly versatile green material with tremendous potential. However, many efforts have been conducted for the evolution of novel and sophisticated materials with environmental affinity, which accompany the empowerment and enhancement of specific properties. In this review article, we summarized only industry and research status regarding BC and contemplated its potential in the use of BC.

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Bacterial cellulose to reinforce urethrovesical anastomosis. A translational study

Abstract: The absence of extrusion, stenosis or urinary fistula after 14 weeks of urethrovesical anastomosis demonstrates cellulosic exopolysaccharide membrane biocompatibility and biointegration with tendency to a thicker wall.

Cited by 12 publications

References 26 publications

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit

Bacterial Cellulose and Its Applications

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