Bacterial chatter in chronic wound infections

Abstract

One of the hallmark characteristics of chronic diabetic wounds is the presence of biofilm‐forming bacteria. Bacteria encapsulated in a biofilm may coexist as a polymicrobial community and communicate with each other through a phenomenon termed quorum sensing (QS). Here, we describe the QS circuits of bacterial species commonly found in chronic diabetic wounds. QS relies on diffusion of signaling molecules and the local concentration changes of these molecules that bacteria experience in wounds. These biochemical signaling pathways play a role not only in biofilm formation and virulence but also in wound healing. They are, therefore, key to understanding the distinctive nature of these infections. While several in vivo and in vitro models exist to study QS in wounds, there has been limited progress in understanding the interplay between QS molecules and host factors that contribute to wound healing. Lastly, we examine the potential of targeting QS for both diagnosis and therapeutic intervention purposes.

Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

“…Bacterial infection and colonization are frequently accompanied by chronic wounds, resulting in an extensive response and persistent inflammatory phase. Moreover, intractable bacterial biofilms may form and severely hinder wound healing [ 22 , 23 ]. Under sufficient pO 2 , neutrophils produce a considerable amount of reactive oxygen species (ROS) to induce the oxidative killing of bacteria through mitochondria and NADPH oxidase, a classic process called “respiratory burst” [ 24 ].…”

In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay

“…Considering that the healing process could be affected also by the presence of bacteria, TH1-3 formulations were further evaluated for their antimicrobial activity against S. aureus , P. aeruginosa , and S. epidermidis . S. aureus , and epidermidis were selected as prototypes of Gram-positive and negative bacteria, respectively, and are notoriously resistant to therapeutics, which frequently colonize chronic wounds [ 32 , 33 , 34 ]. The choice of the selected microorganisms also took into account their prevalence in the various stages of the wound.…”

Research hotspot and trend of chronic wounds: A bibliometric analysis from 2013 to 2022

“…90 Bacteria in biofilms communicate with each other by secreting signalling molecules called autoinducers, thus helping bacteria regulate gene expression in accordance with environmental conditions and evade host immune responses. [91][92][93] Accordingly, quorum sensing has become a new strategy for treating chronic wound infections. Geng et al employed luteolin as a quorum-sensing inhibitor.…”