Bacterial degradation kinetics of poly(Ɛ-caprolactone) (PCL) film by Aquabacterium sp. CY2-9 isolated from plastic-contaminated landfill

Yoon, Younggun; Park, Hyo Jung; An, Si-Hyun; Ahn, Jae-Hyung; Kim, Bongkyu; Shin, Jaedon; Kim, Ye-eun; Yeon, Jehyeong; Chung, Jun-Ki; Kim, Dayeon; Cho, Min

doi:10.1016/j.jenvman.2023.117493

Cited by 14 publications

(3 citation statements)

References 47 publications

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“…PCL has a semicrystalline structure and, under physiological conditions, it maintains high mechanical properties (e.g., elasticity and toughness). The degradation mechanism of PCL implants typically involves hydrolysis of ester linkages and digestion by resident micro-organisms, with a general degradation period of about 2–3 years [ 159 , 160 ]. The degradation product of PCL—caproic acid—is nontoxic to local tissues and can be excreted through the renal system or reabsorbed during metabolic processes [ 161 ].…”

Section: Nanofiber Scaffold Technologymentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Section: Nanofiber Scaffold Technologymentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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“…A major family of commodity polymers which may present favourable biodegradation profiles are the polyesters, 117 with key examples including PLA, 147 polycaprolactone 148 and polyglycolide (PGLA). 149 For these aliphatic polyesters, bulk degradation by chemical hydrolysis is the predominant mechanism at play, for which Bher et al 150 details methods on accelerating this process to give access to units that are able to enter microbial metabolic pathways.…”

Section: Strategies For the Design Of Biodegradable Polymersmentioning

confidence: 99%

Designing biodegradable alternatives to commodity polymers

Fiandra,

Shaw,

Starck

et al. 2023

Chem. Soc. Rev.

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“…Due to its high biocompatibility, blend compatibility, and low biodegradability rates, it is frequently used in long-term biomedical and tissue applications [ 22 – 24 ]. Among biodegradable plastics, PCL can have extended biodegradation times, leading to its accumulation in the environment where it is discarded [ 22 , 25 ]. Total PCL biodegradation may take few months to several years, depending on the environmental conditions, as well as with variations in PCL properties (e.g., molecular weight and crystallinity) [ 24 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Microplastics Biodegradation by Estuarine and Landfill Microbiomes

Pires,

Costa,

Barbosa

et al. 2024

Microb Ecol

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Plastic pollution poses a worldwide environmental challenge, affecting wildlife and human health. Assessing the biodegradation capabilities of natural microbiomes in environments contaminated with microplastics is crucial for mitigating the effects of plastic pollution. In this work, we evaluated the potential of landfill leachate (LL) and estuarine sediments (ES) to biodegrade polyethylene (PE), polyethylene terephthalate (PET), and polycaprolactone (PCL), under aerobic, anaerobic, thermophilic, and mesophilic conditions. PCL underwent extensive aerobic biodegradation with LL (99 ± 7%) and ES (78 ± 3%) within 50–60 days. Under anaerobic conditions, LL degraded 87 ± 19% of PCL in 60 days, whereas ES showed minimal biodegradation (3 ± 0.3%). PE and PET showed no notable degradation. Metataxonomics results (16S rRNA sequencing) revealed the presence of highly abundant thermophilic microorganisms assigned to Coprothermobacter sp. (6.8% and 28% relative abundance in anaerobic and aerobic incubations, respectively). Coprothermobacter spp. contain genes encoding two enzymes, an esterase and a thermostable monoacylglycerol lipase, that can potentially catalyze PCL hydrolysis. These results suggest that Coprothermobacter sp. may be pivotal in landfill leachate microbiomes for thermophilic PCL biodegradation across varying conditions. The anaerobic microbial community was dominated by hydrogenotrophic methanogens assigned to Methanothermobacter sp. (21%), pointing at possible syntrophic interactions with Coprothermobacter sp. (a H2-producer) during PCL biodegradation. In the aerobic experiments, fungi dominated the eukaryotic microbial community (e.g., Exophiala (41%), Penicillium (17%), and Mucor (18%)), suggesting that aerobic PCL biodegradation by LL involves collaboration between fungi and bacteria. Our findings bring insights on the microbial communities and microbial interactions mediating plastic biodegradation, offering valuable perspectives for plastic pollution mitigation.

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Bacterial degradation kinetics of poly(Ɛ-caprolactone) (PCL) film by Aquabacterium sp. CY2-9 isolated from plastic-contaminated landfill

Cited by 14 publications

References 47 publications

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Designing biodegradable alternatives to commodity polymers

Microplastics Biodegradation by Estuarine and Landfill Microbiomes

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