Bacterial Distribution and Antibiotic Susceptibility Pattern of &lt;i&gt;group B Streptococcus β hemolytic &lt;/i&gt;(GBS) in Vaginal Infections at Cotonou in Benin

Tchiakpé, Edmond; Malick, Zahra Fall; Yehouenou, Laurence Carine; Bankolè, Honoré; Wilfried, Bekou Kossi; Marius, Esse Atchéni; Diop-Ndiaye, Halimatou; Kane, Coumba Touré

doi:10.12691/ajidm-5-3-3

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…Primary studies conducted in the East African countries showed the colonization rates ranged from 3.0% to 28.8% [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]; Central Africa,20.0% [27,28]; Western Africa, 2.5% to 34.2% [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; Southern Africa, 1.77% to 48.23% [49][50][51][52][53][54][55][56][57]…”

Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Gizachew

Tiruneh

Moges

et al. 2019

Ann Clin Microbiol Antimicrob

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Background: Maternal rectovaginal colonization with Streptococcus agalactiae (Group B Streptococcus or GBS) is the most common route for the GBS disease in the perinatal period. The knowledge of maternal colonization, antibiotic resistance and serotype profiles is substantially needed to formulate the broad vaccine. However, it has not been estimated in Africa. This meta-analysis was aimed to determine the pooled prevalence of colonization, antibiotic resistance and serotype profiles of GBS reported in Africa. Methods: Potentially relevant studies from 1989 to 31th January, 2019 were retrieved from the Medline/PubMed, EMBASE, HINARI online databases, periodicals and by requesting authors. Unpublished studies retrieved from grey literature through Google and Google Scholar. Pooled estimates were calculated using the random effect model. Subgroup analysis was done to investigate the burden of colonization across sub-regions, sampling site and countries. Summary estimates were presented using words, Forest plots and Tables. Heterogeneity was assessed using the I 2 statistic. Results: Eighty-three articles were assessed, of which 57 studies conducted in five sub-regions with 21 countries (22,206 pregnant women) met pre-specified inclusion criteria. The overall estimate of recto-vaginal colonization was 19.3% (95% CI 16.9, 21.7). The highest estimate was observed in Southern Africa, 23.8% (95% CI 18.7, 28.9), followed by Northern Africa, 22.7% (95% CI 18.2, 27.2) while the lowest was driven from the Eastern Africa, 15.4% (95% CI 12.1, 18.7). Considerable heterogeneity across and within regions, sampling site, screening methods and countries (I 2 > 75%); and the publication bias were observed (p = 0.031). GBS showed the highest resistance to tetracycline. Resistance to penicillin, amoxicillin, chloramphenicol, ampicillin, ceftriaxone, ciprofloxacin, erythromycin, vancomycin and clindamycin also observed. The V, III, Ia, Ib, and II serotypes altogether were accounted 91.8% in the African studies. Conclusions: The pooled estimate of the maternal colonization with GBS was 19.3% which is equivalent with other many primary and review reports worldwide. The most antibiotic resistance estimate was recorded in the tetracycline followed by penicillin. Five serotypes were the most prevalent in Africa and more data on the antibiotic résistance and serotype distribution patterns are needed from developing countries to devise the effective preventive measures. In addition, the antibiotic susceptibility test methods used in the Africa shall be assessed for its quality.

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Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Gizachew

Tiruneh

Moges

et al. 2019

Ann Clin Microbiol Antimicrob

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“…Genital carriage of S. agalactiae and E. coli has been studied in several countries because of the incidence of infection caused by these bacterial species and the carriage rate varies according to geographic area and region (Brochet et al, 2009;Gizachew et al, 2019;Lekala et al, 2015;Madrid et al, 2017). In Benin, Edmond et al (2017) Balaka et al (2005) also found similar results with an overall rate of 79.2% in mono-microbial and 20.8% in poly-microbial. Among the beta-lactams tested, ampicillin shows high resistance in almost all species.…”

Section: Discussionmentioning

confidence: 88%

“…The most sensitive molecule was gentamycin with 0% resistance to Gram positive bacteria except S. agalactiae (1/13 resistance). According to the study conducted in Benin on strains isolated from vaginal samples in women presenting symptoms, 66.7% of S. agalactiae were resistant to ampicillin, 61.5% resistant to gentamycin, 50.5% to erythromycin, and 91.7% with tetracycline (Edmond et al, 2017). Compared to the results obtained for the sensitivity of S. agalatiae to these antibiotics, the resistance rates reported by Edmond et al (2017) were globally higher.…”

Section: Genes Of Resistance To Mlsb P-value Ermb (%) Ermtr (%) Mef(a/e) (%)mentioning

confidence: 95%

“…According to the study conducted in Benin on strains isolated from vaginal samples in women presenting symptoms, 66.7% of S. agalactiae were resistant to ampicillin, 61.5% resistant to gentamycin, 50.5% to erythromycin, and 91.7% with tetracycline (Edmond et al, 2017). Compared to the results obtained for the sensitivity of S. agalatiae to these antibiotics, the resistance rates reported by Edmond et al (2017) were globally higher. This difference can be explained by the asymptomatic nature of the patients recruited and therefore less contact with antibiotics.…”

Section: Genes Of Resistance To Mlsb P-value Ermb (%) Ermtr (%) Mef(a/e) (%)mentioning

confidence: 95%

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Molecular characterization of high-risk infection vaginal bacteria isolated from pregnant women in CHU-MEL of Cotonou (Benin)

Sina¹,

N’tcha²,

Dah-Nouvlessounon³

et al. 2021

Afr. J. Microbiol. Res.

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The aim of this study is to determine the distribution of the genotypic pathogenicity traits of vaginal high-risk infectious bacteria (HRIB) collected in the CHU-MEL of Cotonou (Benin). To achieve this, a recto-vaginal swab of 42 pregnant women in the third trimester of pregnancy was collected. Species identification was carried out by specific biochemical tests. Antimicrobial susceptibility was tested according to the microbiology standard recommendation. Macrolide resistance genes in Gram-positive bacteria and virulence genes in Escherichia coli were investigated by polymerase chain reaction (PCR). E. coli is the most isolated species (14.7%) followed by Klebsiella pneumoniae (11.8%). Mono-microbial carriage was 55.9%. Gram-negative antibiotic susceptibility shows strong resistance to beta lactam. While Gram-positive bacteria showed strong resistance to beta-lactamine, tetracycline and macrolides with cMLS B (70.4%), iMLS B (3.7%) and M (25.9%) phenotypes. ErmB and ermTR were not detected in Gram-positive bacteria but mef(A/E) was detected at a high. Virulence genes in E. coli were detected and fimA was the most common (52.2%) followed by sfa/foc (30.4%) and cnf1 (13.0%). NeuC and ibeA have not been detected. The hvgA virulence gene was detected in S. agalactiae at a rate of 61.54%. These results demonstrate the importance of introducing antenatal screening for HRIB to improve obstetric and neonatal management in Benin.

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“…Age also has an impact on the habitat of the vaginal microbiome [64]. As a result of the differences in microbial community composition among individuals, our understanding of the pathophysiology behind a wide range of illnesses, from atopic dermatitis to hepatocellular cancer, affecting certain areas of the body, is continually expanding [65,66]. It has been demonstrated that the VM's structure affects IVF results, particularly diagnostic conception rate, implantation rates, and live birth rates, all of which are pertinent in uterine transplantation, where the live birth of a healthy infant is the main objective.…”

Section: Influence On Sexual Health and Reproductive Healthmentioning

confidence: 99%

Influence of Vaginal Microbiota on Sexual and Reproductive Health: A Mini Review

Don¹,

Padma²,

Chandana³

et al. 2023

Entomol Appl Sci Lett

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Over 150 years ago, investigations were started on the vaginal microbiota (VMB). Women's health and reproduction are significantly influenced by the vaginal microbiome. The vaginal microbiota plays a critical role in preserving vaginal health and safeguarding the host against illness. Understanding the variables that affect the bacterial communities' stability in the vagina may aid in identifying the likelihood of developing diseases that are harmful to women's health. Numerous microorganisms can be found in vaginal secretions, and the host feeds them nutrients for expansion and development. The menstrual cycle and sex hormones, contraceptives, and the vaginal microbiome all have an impact on the risk of infection and disease, unfavorable pregnancy outcomes, and the success of fertility treatments. The likelihood of getting diseases including STIs, bacterial vaginosis, fungal infections, premature birth, etc. increases as a result of changes in the vaginal environment brought on by disruptions in the vaginal contact with the microbiomes. Bacterial vaginosis microbiota has been linked to endometritis after elective abortions, pelvic inflammatory illness, vaginal discharge, and poor pregnancy outcomes. There is mounting evidence that a woman's vaginal microbiota composition has a substantial impact on their sexual and reproductive health, including her risk of miscarriage, premature birth, and HIV infection, The review's main emphasis is on a thorough influence of the microbial ecosystem of the human vagina and how they affect women's health and reproductive outcomes in different stages of women's life cycle which involves different vaginal infections such as bacterial vaginosis, trichomoniasis, cervical and endometrial cancer, etc.

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Bacterial Distribution and Antibiotic Susceptibility Pattern of <i>group B Streptococcus β hemolytic </i>(GBS) in Vaginal Infections at Cotonou in Benin

Cited by 3 publications

References 20 publications

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Molecular characterization of high-risk infection vaginal bacteria isolated from pregnant women in CHU-MEL of Cotonou (Benin)

Influence of Vaginal Microbiota on Sexual and Reproductive Health: A Mini Review

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