Bacterial Etiologies of Ear Infection and Their Antimicrobial Susceptibility Pattern at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia: A Six-Year Retrospective Study

Getaneh, Alem; Ayalew, Getnet; Belete, Debaka; Jemal, Mohabaw; Biset, Sirak

doi:10.2147/idr.s332348

Cited by 19 publications

(11 citation statements)

References 48 publications

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“…Also, the mean age of the patients studied ranged between 17 and 18 years. [14][15][16] In line with previous reports, although our study had a slight female predilection, we did not observe a significant gender predominance. The mean age of our study sample was also consistent with those reported in former studies.…”

supporting

confidence: 92%

“…Getaneh et al reported a high resistance rate against tetracycline, penicillin, co-trimoxazole, chloramphenicol, and erythromycin. 15 However, low resistance rates to fluoroquinolones, aminoglycosides, and cephalosporins were reported in the same study. 15 High resistance rates to penicillin, tetracycline, and macrolides were found in studies from different regions of Sub-Saharan Africa.…”

Section: Discussionmentioning

confidence: 72%

“…15 However, low resistance rates to fluoroquinolones, aminoglycosides, and cephalosporins were reported in the same study. 15 High resistance rates to penicillin, tetracycline, and macrolides were found in studies from different regions of Sub-Saharan Africa. [24][25][26] The current study detected a high resistance rate against penicillin-class antibiotics, erythromycin, tetracycline, and co-trimoxazole.…”

mentioning

confidence: 72%

“…As a result of these efforts, studies have been conducted in developing countries. [14][15][16] While a female or male predilection was reported in those studies, there was no significant gender predominance for CSOM. Also, the mean age of the patients studied ranged between 17 and 18 years.…”

mentioning

confidence: 78%

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Microbiology and Drug Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media at a Tertiary Care Hospital in Somalia

Ali

Duman

Bozdağ

et al. 2022

IDR

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Background: This study aimed to determine the microbiological profile and antibiotic susceptibility pattern of bacterial isolates obtained from patients with chronic suppurative otitis media (CSOM) presenting to the otorhinolaryngology clinic of a tertiary care hospital in Mogadishu, Somalia. Methods: A total of 225 patients diagnosed with chronic suppurative otitis media were included in the study. Samples of middle ear discharge were collected from each patient and cultured using standard microbiological techniques, and bacterial identification was performed. Drug susceptibility pattern was assessed according to the Clinical and Laboratory Standards Institute criteria. Results:The study sample (n=225) comprised 122 females and 103 males. Among 225 samples tested, bacterial growth was present in 200 (88.9%) and absent in 25 (11.1%) samples. Of 200 samples with bacterial growth, monomicrobial growth was detected in 176 (88%). Gram-positive bacteria were observed in 40 (22.7%) and Gram-negative bacteria in 136 (77.3%) samples. The bacteriology of the samples with monomicrobial growth consisted of (in decreasing frequency) Pseudomonas spp, Staphylococcus aureus, Escherichia coli, Coagulase-negative staphylococci, Proteus mirabilis, and Klebsiella sp. A high rate of resistance was detected against penicillin antibiotics, erythromycin, tetracycline, and co-trimoxazole. Resistance to cephalosporins, clindamycin, vancomycin, linezolid, daptomycin, quinupristin/dalfopristin, levofloxacin, meropenem, and ertapenem was low. Conclusion: While the frequencies of isolated bacterial species were consistent with other reports from the region, differences were observed in the antibiotic resistance of bacterial isolates when examined individually for each antibiotic. Further studies are warranted in the same region and different parts of Somalia, coupled with ongoing assessment of antibiotic susceptibility patterns in CSOM.

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confidence: 92%

Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 72%

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confidence: 78%

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Microbiology and Drug Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media at a Tertiary Care Hospital in Somalia

Ali

Duman

Bozdağ

et al. 2022

IDR

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“…In Ethiopia, few studies have investigated bacteriological profiles and antimicrobial susceptibility patterns of the middle ear discharge. The number of antibiotic-resistant bacteria is alarming and becoming a major public health problem in the management of patients with middle ear infection (13)(14)(15). There are no data on the prevalence and antimicrobial susceptibility patterns of bacterial pathogens from middle ear infections in referred health facilities.…”

Section: Introductionmentioning

confidence: 99%

Bacterial etiologies, antimicrobial susceptibility profiles and associated factors among patients with otitis media referred to Nekemte Public Health Research and Referral Laboratory Center, Western Ethiopia: A prospective cross-sectional study

Guteta,

Abdi,

Feyisa

et al. 2024

Preprint

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BackgroundOtitis media is among the leading causes of illnesses responsible for causing hearing problems and adding significant costs to the public health system. Bacteria are the most common causative agents for otitis media. Currently, there is little information on the prevalence and antimicrobial susceptibility patterns of pathogenic bacterial isolates from patients with otitis media in Ethiopia.MethodologyA laboratory – based cross-sectional study was conducted from June to September 2023 among 242 patients with otitis media referred to Nekemte Public Health Research and Referral Laboratory Center. Sociodemographic and clinical data were obtained by trained nurses and/or health officers in face-to-face interviews using structured questionnaires. Middle ear discharge samples were collected by trained clinical microbiology experts following all aseptic techniques. Conventional culture, different biochemical tests and antimicrobial susceptibility testing were performed for all the isolated bacteria. Reference strains were used as a positive and negative controls. The data were checked for completeness and consistency, entered into EpiData version 4.6.06 and analyzed by SPSS version 25. Logistic regression analysis was performed to determine the associated factors of otitis media. Adjusted odds ratio was used to determine strength of association. Statistical significance was obtained at p-value of below 0.05. The data were interpreted using graphs, tables, and results statements.ResultsA total of 242 middle ear discharge samples were collected and cultured from which 212 (87.6%) were culture positive. A total of 228 pathogenic bacterial isolates were recovered. The predominant bacterial isolates wereS. aureus92 (40.4%) followed byP. aeruginosa33 (14.5%) andE. coli24 (10.5%). One hundred fifty-one (66.2%) bacterial pathogens were multidrug resistant. Piperacillin-tazobactam and tobramycin are relatively common drugs to which most of the isolates were susceptible while ampicillin and tetracycline were the most resistant. Purulent discharge (p-value = 0.001), middle ear discharge ≥14 days (P-value = 0.000) and a history of active/passive smoking (P-value = 0.043) were significantly associated with otitis media.ConclusionThe prevalence of bacterial pathogens, most of which were multidrug-resistant, was high among patients with otitis media. A significant association was observed with purulent ear discharge, chronic otitis media, and passive or active smoking. Choosing the proper antibiotic for the treatment of bacterial infection is crucial.

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Citrobacter Infections in Children and Hearing Loss

Emiroğlu,

Turgut,

Tenenbaum

2023

Comprehensive ENT

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Bacterial Etiologies of Ear Infection and Their Antimicrobial Susceptibility Pattern at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia: A Six-Year Retrospective Study

Cited by 19 publications

References 48 publications

Microbiology and Drug Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media at a Tertiary Care Hospital in Somalia

Microbiology and Drug Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media at a Tertiary Care Hospital in Somalia

Bacterial etiologies, antimicrobial susceptibility profiles and associated factors among patients with otitis media referred to Nekemte Public Health Research and Referral Laboratory Center, Western Ethiopia: A prospective cross-sectional study

Citrobacter Infections in Children and Hearing Loss

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