Bacterial Etiology of Early Onset and Late Onset Sepsis in Menoufia University Hospital : Trends in Antimicrobial Susceptibility Patterns

Mahmoud, Ahmed B; Eissa, Naira A; Gendy, Fady M. El

doi:10.12816/0004925

Cited by 2 publications

(4 citation statements)

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“…7,19,24 K. pneumoniae was the predominant pathogen, as has been reported in other studies. 9,16,21,23 Group B streptococcus was the most prevalent Gram-positive pathogen in our study, which contrasts with the findings in other published literature from low-to middleincome settings, in which the total absence of this pathogen was reported.…”

Section: Pathogen Spectrumsupporting

confidence: 79%

“…9,16,21,23 Group B streptococcus was the most prevalent Gram-positive pathogen in our study, which contrasts with the findings in other published literature from low-to middleincome settings, in which the total absence of this pathogen was reported. 19,22,24 Pregnant women are not routinely screened for group B streptococcus in our setting and the isolation of group B streptococcus in our study is an indication of missed opportunities for antenatal screening. Notably, fungal pathogens, i.e.…”

Section: Pathogen Spectrummentioning

confidence: 94%

“…Our study and others from Africa report a higher prevalence of late-onset neonatal sepsis. 12,17,23,24 This pattern represents horizontal infection transmission, i.e. hospitalacquired infections, which are largely preventable by good infection control practices.…”

Section: Timing Of Neonatal Septicaemiamentioning

confidence: 99%

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Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

Mudzikati

Dramowski

2015

Southern African Journal of Infectious Diseases

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Background: Septicaemia is the third most common cause of neonatal death after prematurity and birth asphyxia. The prevalence of neonatal sepsis and the spectrum of causative microorganisms fluctuates over time, thus facility-specific surveillance of neonatal bloodstream infections is important. Increasing levels of antimicrobial resistance documented worldwide, necessitate regular monitoring of institutional resistance patterns to ensure appropriate and effective empirical antimicrobial therapy. Method:The laboratory blood culture reports and patient records from a neonatal unit at a Botswana referral hospital were retrospectively reviewed to determine the one-year prevalence of neonatal sepsis and the antimicrobial susceptibility patterns of common pathogens. Results: Of 909 neonates investigated for suspected sepsis using 1 119 blood cultures, 89 (9.8%) had laboratory-confirmed episodes of bloodstream infection (septicaemia). The most prevalent pathogens included Klebsiella pneumoniae (29.4%), group B streptococcus (16.3%) and Escherichia coli (11.9%). Blood culture contamination rates were high at 18.6% (208/1 119). Gramnegative pathogens showed low susceptibility to gentamicin (40%) and cefotaxime (47%), but high susceptibility to amikacin (86%). Streptococci and enterococci were moderately sensitive to ampicillin (79%), and fully susceptible to vancomycin. Methicillin-resistant Staphylococcus aureus was not isolated. Exposure to maternal syphilis and previous antibiotic exposure were significantly associated with neonatal septicaemia. Conclusion: Neonatal sepsis is common, with a predominance of Gram-negative pathogens. The high rate of blood culture contamination should be addressed. Emerging antibiotic resistance may require clinicians to review currently used antibiotics for the empirical treatment of late-onset neonatal septicaemia.

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Section: Pathogen Spectrumsupporting

confidence: 79%

Section: Pathogen Spectrummentioning

confidence: 94%

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Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

Mudzikati

Dramowski

2015

Southern African Journal of Infectious Diseases

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“…Our search of the databases yielded 3878 citations: 1618 from Medline, 1688 from Web of Science, 210 from Cochrane Library and 362 from IMEMR (figure 1). We also identified seven articles from other sources 23–29. Of these, 1199 were duplicate articles that were removed.…”

Section: Resultsmentioning

confidence: 99%

Neonatal early onset sepsis in Middle Eastern countries: a systematic review

Khalil

Blunt

et al. 2020

Arch Dis Child

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BackgroundEarly onset neonatal sepsis (EOS) accounts for a significant portion of neonatal mortality, which accounts for 46% of global under five child mortality.ObjectiveThis systematic review studies the bacterial aetiology of EOS in the Middle East, susceptibility patterns to recommended empirical antibiotic therapy and whether this differs between high-income and middle-income countries in the region.MethodsArticles were collected from Medline, Web of Science, the Cochrane Library and Index Medicus for the Eastern Mediterranean Region. The articles included in our systematic review met the following criteria: published after January 2000, data relevant to the Middle East, data specific for early onset sepsis, no language restriction. Data on aetiology and susceptibility were extracted from prospective and retrospective studies. Risk of bias was assessed using the Newcastle-Ottawa Scale. This study focused on EOS but does include data regarding neonatal late-onset sepsis antibiotic susceptibility. The data regarding coagulase-negative Staphylococcus species were excluded from final analysis, as possible contaminants. The protocol for this systematic review was registered on PROSPERO: CRD42017060662.Results33 articles from 10 countries were included in the analysis. There were 2215 cases of culture-positive EOS, excluding coagulase-negative Staphylococcus. In middle-income countries, Klebsiella species (26%), Staphylococcus aureus (17%) and Escherichia coli (16%) were the most common pathogens, in contrast to group B Streptococcus (26%), E. coli (24%) and Klebsiella (9%) in high-income countries. Overall susceptibility to ampicillin/gentamicin and third-generation cephalosporin were 40% and 37%, respectively, in middle-income countries versus 93% and 91%, respectively, in high-income countries.ConclusionsEOS in middle-income countries was more likely to be due to Gram-negative pathogens and less likely to be susceptible to empirical antibiotic therapy. This has important public health implications regarding neonatal mortality in the Middle East region.

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Bacterial Etiology of Early Onset and Late Onset Sepsis in Menoufia University Hospital : Trends in Antimicrobial Susceptibility Patterns

Cited by 2 publications

References 0 publications

Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

Neonatal early onset sepsis in Middle Eastern countries: a systematic review

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