1989
DOI: 10.1038/337385a0
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Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor

Abstract: Cysteine proteinases are important not only in the intracellular catabolism of peptides and proteins and in the processing of prohormones and proenzymes, but also in the penetration of normal human tissue by malignant cells and possibly microorganisms, including viruses. Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. We have synthesized peptide derivatives mimicking the proposed proteinase-binding centre of cystatin C and find that they irreversibly inhibit cysteine protei… Show more

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Cited by 201 publications
(120 citation statements)
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“…Until now, to our knowledge, no other substrate for IdeS had been identified (4,6). In addition, IdeS is not affected by the typical cysteine proteinase inhibitor E-64 (4,6), which is in sharp contrast to the described prokaryotic cysteine proteinases (16)(17)(18)(19), and suggests a unique catalytic property of IdeS. Like the classical streptococcal cysteine proteinase, SpeB (streptococcal pyrogenic exotoxin B), IdeS contains an RGD motif (4,14,15), which is involved in the interaction of IdeS with vitronectin (␣ V␤3 ) and platelet receptors (␣ II␤3 ) (21), suggesting additional, yet unknown properties of the enzyme.…”
mentioning
confidence: 46%
“…Until now, to our knowledge, no other substrate for IdeS had been identified (4,6). In addition, IdeS is not affected by the typical cysteine proteinase inhibitor E-64 (4,6), which is in sharp contrast to the described prokaryotic cysteine proteinases (16)(17)(18)(19), and suggests a unique catalytic property of IdeS. Like the classical streptococcal cysteine proteinase, SpeB (streptococcal pyrogenic exotoxin B), IdeS contains an RGD motif (4,14,15), which is involved in the interaction of IdeS with vitronectin (␣ V␤3 ) and platelet receptors (␣ II␤3 ) (21), suggesting additional, yet unknown properties of the enzyme.…”
mentioning
confidence: 46%
“…High concentrations of stefin A selectively localized Table 1 Inhibition constants (Ki,,,) [23,24]. There is an abundance of stefin A mRNA in chemically induced mouse skin papillomas but a decrease in mRNA with progression to carcinomas [8].…”
Section: Discussionmentioning
confidence: 99%
“…kocytes from recognizing chemotactic signals (41), the protease that may be involved in invasive infections (4,5), and the pyrogenic exotoxins important in scarlet fever and implicated in toxic streptococcal syndrome (3,35,40).…”
mentioning
confidence: 99%