Bacterial Homeostasis and Tolerance to Potentially Toxic Metals and Metalloids through Diverse Transporters: Metal-Specific Insights

Adhikary, Samarpita; Saha, Jayanti; Dutta, Prajesh; Pal, Ayon

doi:10.1080/01490451.2024.2340517

Geomicrobiology Journal

2024

DOI: 10.1080/01490451.2024.2340517

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Bacterial Homeostasis and Tolerance to Potentially Toxic Metals and Metalloids through Diverse Transporters: Metal-Specific Insights

Samarpita Adhikary,

Jayanti Saha,

Prajesh Dutta

et al.

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2024

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Cited by 2 publications

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Clinical and In Vitro Safety of Heyndrickxia coagulans AO 1167B: A Double-Blind, Placebo-Controlled Trial

García,

Soto,

Díaz

et al. 2024

Microorganisms

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(1) Background: Heyndrickxia coagulans, a lactic acid-producing bacterium, displays characteristics of both Lactobacillus and Bacillus genera. Clinical evidence suggests its potential health benefits. This study evaluated the safety of H. coagulans AO1167B as a candidate probiotic supplement. (2) Methods: Strain identification was confirmed through morphological, cultural, and genomic analyses, including 16S RNA and whole genome sequencing to assess antimicrobial resistance and virulence factors. Phenotypic tests, such as disk diffusion for antimicrobial resistance, and safety assays for cytotoxicity and hemolytic activity, were conducted. In a phase I, double-blind, placebo-controlled clinical trial, healthy adults were randomized into H. coagulans AO1167B and placebo groups for 60 days. Daily capsule consumption was monitored through clinical and hematological evaluations, adverse event tracking, and health surveys. (3) Results: The genome of H. coagulans AO1167B revealed no concerning features. Disk diffusion tests showed no antimicrobial resistance. The strain exhibited no cytotoxic or hemolytic activity, indicating in vitro safety. No significant differences in clinical or hematological parameters were observed between groups. The most common adverse event, gas, diminished over time. (4) Conclusions: H. coagulans AO1167B demonstrates a suitable safety profile, genetic stability, and probiotic potential for gastrointestinal health, justifying further clinical research.

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Clinical and In Vitro Safety of Heyndrickxia coagulans AO 1167B: A Double-Blind, Placebo-Controlled Trial

García,

Soto,

Díaz

et al. 2024

Microorganisms

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Mechanisms of Heavy Metal Tolerance in Bacteria: A Review

Nnaji,

Anyanwu,

Miri

et al. 2024

Sustainability

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Heavy metal pollution from industrial activities and poor waste disposal poses significant environmental and health threats to humans and animals. This calls for sustainable approaches to the cleanup of heavy metals. This review explores metal tolerance mechanisms of bacteria such as the formation of biofilms, efflux systems, and enzymatic detoxification. These mechanisms allow bacteria communities to adapt and survive in contaminated environments. These adaptations are enhanced by mutations in the bacteria genes and by horizontal gene transfers, enabling bacteria species to survive under environmental stress while simultaneously contributing to nutrient cycling and the decomposition of organic matter. This review further explores the symbiotic interactions between bacteria, plants, and animals. These relationships enhance the metal tolerance ability of the different living organisms involved and are also very important in the bioremediation and phytoremediation of heavy metals. Plant growth-promoting rhizobacteria, Rhizobium, and Bacillus species are very important contributors to phytoremediation; they improve heavy metal uptake, improve the growth of roots, and plants resilience to stress. Moreover, this review highlights the importance of genetically engineered bacteria in closed-loop systems for optimized metal recovery. This offers environmentally friendly and sustainable options to the traditional remediation methods. Engineered Cupriavidus metallidurans CH34 and Pseudomonas putida strain 15420352 overexpressing metallothioneins have shown enhanced metal-binding capabilities, which makes them very effective in the treatment of industrial wastewaters and in biosorption applications. The use of engineered bacteria for the cleanup of heavy metals in closed-loop systems promotes the idea of a circular economy by recycling metals, thus reducing environmental waste. Multidisciplinary research that integrates synthetic biology, microbial ecology, and environmental science is very important for the advancement of metal bioremediation technologies. This review’s analysis on bacterial metal tolerance, symbiosis, and bioengineering strategies offers a pathway to effective bioremediation options, for the reclamation of heavy metal-polluted environments while promoting sustainable environmental practices.

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Bacterial Homeostasis and Tolerance to Potentially Toxic Metals and Metalloids through Diverse Transporters: Metal-Specific Insights

Cited by 2 publications

References 381 publications

Clinical and In Vitro Safety of Heyndrickxia coagulans AO 1167B: A Double-Blind, Placebo-Controlled Trial

Clinical and In Vitro Safety of Heyndrickxia coagulans AO 1167B: A Double-Blind, Placebo-Controlled Trial

Mechanisms of Heavy Metal Tolerance in Bacteria: A Review

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