Bacterial Indicators of Abscesses and Phlegmon of the Maxillofacial Region in Patients Living in the Poltava Region

Steblovskyy, D. V.; Skikevych, M. H.; Voloshyna, L. I.; Popovych, І. Yu.; Skrypnyk, V.M.

doi:10.29254/2077-4214-2019-4-1-153-347-350

Cited by 2 publications

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“…Питанням оптимізації хірургічного та медикаментозного лікування одонтогенних флегмон щелепно-лицевої локалізації протягом тривалого часу займаються, як вітчизняні, так і закордонні дослідники та клініцисти. Позитивні результати щодо нормалізації імунологічної реактивності організму пацієнта було доведено за умов використання препаратів групи адаптогенів, які мають імуномодулюючу (нормалізуючу) дію незалежно від типу реагування організму на інфекційний процес [5,6]. Добре себе зарекомендувало використання антиоксидантів з метою Актуальні проблеми сучасної медицини корекції метаболічних порушень та підвищення антиоксидантного захисту організму, яке обумовлено підвищеним рівень вільно-радикального окислення за умов гнійно-запальних процесів [7].…”

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Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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A large cohort of scientists is dealing with the issue of improving the treatment of maxillofacial odontogenic phlegmons. The course of these diseases is impacted by a significant number of factors, one of which is ishemic heart disease. Quercetin is a powerful antioxidant with a pronounced antioxidant effect. The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate leads to increased oxidation of components, that is, to a synergistic antioxidant effect. The purpose of this study is to enhance the therapy of odontogenic phlegmons of maxillofacial area in patients with ishemic heart disease through the combined use of drugs with antioxidant, antihypoxant and angioprotective effects. Materials and methods. 80 patients with odontogenic phlegmon of maxillofacial area were examined. The participants were categorized into the following groups: Group 1 received parenteral quercetin, Group 2 received a combination of quercetin and intravenous administration of 2-ethyl-6-methyl-3-hydroxypyridine succinate, Group 3 received standard treatment (20 individuals), and Group 4 (control) comprised individuals without concomitant pathology who received the treatment according to a standard protocol (20 patients). To analyze the state of free radical oxidation processes in blood serum, the content of diene conjugates was studied. Results. The level of diene conjugates was increased when compared to the control group by 93.2%, 95.0% and 96.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the third day of observation, patients with coronary heart disease displayed an increase in the studied indicator by 99.1%, 100.6%, and 97.8%, respectively, compared to the controls. After 5 days, in all four clinical groups, there was a decrease in diene conjugates content in blood serum compared to the previous observation period by 6.9%, 8.2%, 5.3% and 11.8%, respectively. A tendency to a gradual decrease in the content of diene conjugates was observed on the 7th day of observation in all groups by 5.5%, 6.8%, 4.2% and 11.8%, respectively, with its increase relative to the control by 112.9 %, 108.7% and 118.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the 9th day of observation, a decrease in DC content by 2.7% was found only in patients of the 2nd clinical group. At the final follow-up period, a decrease in this marker was noted in all studied clinical groups relative to the previous follow-up period by 5.1%, 6.9%, 2.3%, and 9.7%, respectively. Conclusion: Under the combined administration of quercetin and 2-ethyl-6-methyl-3-hydroxypyridine succinate alongside a standard treatment protocol, the reduction in the level of diene conjugates in blood serum was most significant among patients with coronary heart disease, particularly in the later stages following surgical treatment.

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Section: вступunclassified

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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Effect of Integrated Treatment on Reparative Regeneration of Wounds and Bone Defects in Children With Odontogeneous Phlegmons

Tkachenko,

Bilokon,

Lokhmatova

et al. 2024

Act. Probl. of the Modern Med.

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The achievements of modern septic surgery are associated with the implementation of the latest technologies and new generations of pharmacological drugs, the action of which is aimed at correcting existing disorders. Recently, special literature has presented encouraging data regarding the effectiveness of placenta cryoextract in treating inflammatory processes of the maxillofacial area. However, little attention has been given to its application in children. Objective of this study is to investigate the effectiveness of comprehensive treatment on the processes of reparative regeneration in wound and bone tissue in children with odontogenic phlegmons. Subjects and methods. In order to assess the course of the wound process, 29 children with phlegmons localized directly in the submandibular area were selected; the length of the incision was 5 cm. In the first group, involving 16 people, a set of measures was carried out in accordance with the medical care protocol, and in the second group, consisting of 13 patients, on the second day after the operation, an aseptic bandage with "Levomekol" ointment was applied to the wound surface with the addition of cryoextract of the placenta in ratios of 5:1. In order to objectify the results, pH-metry of the wound exudate was performed, a planimetric study was performed to establish the speed of retraction of the wound edges, and the cellular composition of the wound exudate was analyzed for 1, 3, and 8 days. On the first day after surgery, changes in these parameters in both groups were of the same type. On the third day, in the second group of children, the pH level improved by 9.5%, and the speed of retraction of the wound edges increased by 9.0% compared to the first group. On the 8th day, the concentration of hydrogen ions in this group increased by 9.4%, and the average area of the wound surface became smaller by 8.2% compared to the previous values. The cellular composition of the cytograms also indicated the advantages of wound healing in this group of patients. In the first group, comprising 16 individuals, a standard set of measures was implemented following the medical care protocol. In the second group, consisting of 13 patients, an aseptic bandage with "Levomekol" ointment, supplemented with cryoextract of placenta at a ratio of 5:1, was applied to the wound surface on the second post-operation day. To objectively assess the outcomes, pH-metry of the wound exudate was conducted, alongside planimetric studies to determine the rate of wound edge retraction. Additionally, the cellular composition of the wound exudate was analyzed at 1, 3, and 8 days post-operation. On the first day after the operation, both groups exhibited similar changes in these parameters. However, by the third day, the second group demonstrated a 9.5% improvement in pH levels and a 9.0% increase in the speed of wound edge retraction compared to the first group. By the eighth day, the second group displayed a 9.4% rise in hydrogen ion concentration, and the average wound surface area decreased by 8.2% compared to previous measurements. Furthermore, cytogram analysis indicated superior wound healing advantages in this group of patients. Conclusion. The comparison of clinical and laboratory indicators at the observation stages allowed us to determine that the combined application of topical "Levomekol" ointment with the additional incorporation of placenta cryoextract in its composition improves the conditions of the wound healing process. This improvement is evidenced by the dynamics of changes in the pH indicator, the results of planimetry, and the cellular composition of the exudate.

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Bacterial Indicators of Abscesses and Phlegmon of the Maxillofacial Region in Patients Living in the Poltava Region

Cited by 2 publications

References 0 publications

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Effect of Integrated Treatment on Reparative Regeneration of Wounds and Bone Defects in Children With Odontogeneous Phlegmons

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