Bacterial‐induced epithelial damage promotes fungal biofilm formation in a sheep model of sinusitis

Boase, Sam; Jervis-Bardy, Joshua; Cleland, Edward John; Pant, Harshita; Tan, Lorwai; Wormald, Peter‐John

doi:10.1002/alr.21138

Cited by 37 publications

(31 citation statements)

References 61 publications

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“…The frequent presence of biofilm-forming organisms represents a large reservoir for opportunistic infections. 1110 However, the low number of studies, the diversity of the different study cohorts, and the missing universal definition of AECRS make it difficult to draw any conclusion concerning the role of bacteria in AECRS. Clinical experience suggests antibiotics that cover the most common organisms associated with both ARS and CRS are likely effective in reducing the exacerbation of AECRS.…”

Section: Ixb Aecrs: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

557

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Ixb Aecrs: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

557

888

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“…In a sheep model, bacteria appear to induce epithelial damage that promotes fungal biofilm formation by A. fumigatus. Co-inoculation of Staphylococcus aureus ( S. aureus ) and A. fumigatus into sheep sinuses resulted in an 80% formation of biofilms versus 10% with A. fumigatus inoculation alone [74,75]. Such interaction may provide better surface adherence and ECM formation.…”

Section: Role Of Biofilmmentioning

confidence: 99%

Chronic Illness Associated with Mold and Mycotoxins: Is Naso-Sinus Fungal Biofilm the Culprit?

Brewer

Thrasher²,

Hooper³

2013

Toxins

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It has recently been demonstrated that patients who develop chronic illness after prior exposure to water damaged buildings (WDB) and mold have the presence of mycotoxins, which can be detected in the urine. We hypothesized that the mold may be harbored internally and continue to release and/or produce mycotoxins which contribute to ongoing chronic illness. The sinuses are the most likely candidate as a site for the internal mold and mycotoxin production. In this paper, we review the literature supporting this concept.

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“…There are many species of Aspergillus that cause infections in humans and animals. Eighty percent of fungal sinusitis and invasive fungal rhinosinusitis cases are caused by Aspergillus (most often A. fumigatus) (Li et al, 2012;Chen et al, 2011;Boase et al, 2013;Ma et al, 2013;Rupa and Thomas, 2013;Rane et al, 2014). With a small spore diameter, A. fumigatus can be spread in the air.…”

Section: Introductionmentioning

confidence: 99%

Distinguishing the dominant species of pathogen in maxillary sinusitis by sequencing DNA dataset analysis

Zhang

et al. 2015

Gene

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Bacterial‐induced epithelial damage promotes fungal biofilm formation in a sheep model of sinusitis

Cited by 37 publications

References 61 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Chronic Illness Associated with Mold and Mycotoxins: Is Naso-Sinus Fungal Biofilm the Culprit?

Distinguishing the dominant species of pathogen in maxillary sinusitis by sequencing DNA dataset analysis

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