Bacterial Infection in Chronic Obstructive Pulmonary Disease

Murphy, Timothy F.; Sethi, Sanjay

doi:10.1164/ajrccm/146.4.1067

Cited by 459 publications

(283 citation statements)

References 90 publications

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“…The two COPD populations in the present study did not differ in terms of age or smoking history, although a significantly lower level of respiratory function was found in the group with the exacerbation (table 1). However, as this was a cross-sectional study, it is likely that this difference was due to the increased pulmonary inflammation during the acute exacerbation [24]. Further studies after the resolution of the exacerbation may resolve this issue.…”

Section: Discussionmentioning

confidence: 87%

MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients

Viglio¹,

Iadarola²,

Lupi³

et al. 2000

Eur Respir J

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Degradation of extracellular matrix components is central to many pathological features of chronic destructive lung disorders. Desmosine and isodesmosine are elastin-derived cross-linked amino acids whose urine levels are considered representative of elastin breakdown.The aim of this study was to apply a novel methodology, based on high-performance capillary electrophoresis, to the quantification of desmosine and isodesmosine in 11 patients with stable chronic obstructive pulmonary disease (COPD), 10 with an exacerbation of COPD, nine with a 1 -antitrypsin deficiency, 13 with bronchiectasis, and 11 adults with cystic fibrosis, in comparison to 24 controls.It was found that, in patients with stable COPD, urinary desmosine levels were higher than in controls (p=0.03), but lower than in COPD subjects with an exacerbation (p#0.05). The highest desmosine levels were found in subjects with a 1 -antitrypsin deficiency, bronchiectasis and cystic fibrosis (p<0.001 versus stable COPD). In a shortterm longitudinal study, five stable COPD patients showed a constant rate of desmosine excretion (mean coefficient of variation <8% over three consecutive days).In conclusion, the present method is simple and suitable for the determination of elastin-derived cross-linked amino acid excretion in urine, giving results similar to those obtained using other separation methods. In addition, evidence is presented that urinary desmosine excretion is increased in conditions characterized by airway inflammation, such as exacerbations of chronic obstructive pulmonary disease, bronchiectasis and cystic fibrosis. Results obtained in subjects with a 1 -antitrypsin deficiency suggest that this method might be used to evaluate the putative efficacy of replacement therapy. Eur Respir J 2000; 15: 1039±1045. Chronic obstructive pulmonary disease (COPD), with or without inherited deficiency of a 1 -antitrypsin (AAT), disseminated bronchiectasis (Bx) and cystic fibrosis (CF) are destructive lung disorders characterized by chronic and irreversible airflow limitation. Irrespective of the aetiological factors implicated, there is a solid body of evidence suggesting that degradation of the extracellular matrix component, mainly elastin, due to an imbalance between proteinases and their naturally occurring inhibitors, is central to many of the pathological features of these conditions [1±4].Excess lung elastin degradation results in the excretion of elastin-derived peptides containing desmosine (DES) and isodesmosine (IDES) in urine [5]. Since these crosslinked amino acids are unique to mature elastin, their urine levels are considered to be representative of body elastin breakdown. Urinary excretion of DES and IDES has been reported to be increased in patients with COPD, current smokers with normal lung function [6] and adults with CF [7] compared to appropriate controls.There are two validated means of detecting DES and IDES in body fluids: a separation method, based on isotope -dilution/high -performance liquid chromatography (HPLC) [8], and ...

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Section: Discussionmentioning

confidence: 87%

MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients

Viglio¹,

Iadarola²,

Lupi³

et al. 2000

Eur Respir J

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“…O diagnóstico de pneumonia baseou-se no aparecimento de infiltrado pulmonar recente no radiograma de tórax associado a pelo menos dois dos seguintes sinais: secreção traqueobrônquica purulenta, elevação da temperatura corporal (superior a 38,3ºC) e aumento do número de leucócitos circulantes superior a 25% do número basal 16 .…”

Section: M M M Métodos éTodos éTodos éTodos éTodosunclassified

Validade de um índice prognóstico para ocorrência de complicações pulmonares no pós-operatório de cirurgia abdominal alta

Filardo¹,

Faresin²,

Fernandes³

2002

Rev. Assoc. Med. Bras.

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Observar se a freqüência de complicações pulmonares observadas no pós-operatório de cirurgia abdominal pulmonares observadas no pós-operatório de cirurgia abdominal pulmonares observadas no pós-operatório de cirurgia abdominal pulmonares observadas no pós-operatório de cirurgia abdominal pulmonares observadas no pós-operatório de cirurgia abdominal alta eletiva corresponde a freqüência estimada pelo índice prognós-alta eletiva corresponde a freqüência estimada pelo índice prognós-alta eletiva corresponde a freqüência estimada pelo índice prognós-alta eletiva corresponde a freqüência estimada pelo índice prognós-alta eletiva corresponde a freqüência estimada pelo índice prognós-tico de Pereira et al , insuficiência respiratória aguda (11/87;13%), ventilação mecânica prolongada respiratória aguda (11/87;13%), ventilação mecânica prolongada respiratória aguda (11/87;13%), ventilação mecânica prolongada respiratória aguda (11/87;13%), ventilação mecânica prolongada respiratória aguda (11/87;13%), ventilação mecânica prolongada (8/87;9%) e infecção brônquica (2/87;2%). A análise univariada, (8/87;9%) e infecção brônquica (2/87;2%). A análise univariada, (8/87;9%) e infecção brônquica (2/87;2%). A análise univariada, (8/87;9%) e infecção brônquica (2/87;2%). A análise univariada, (8/87;9%) e infecção brônquica (2/87;2%). A análise univariada, seguida pela regressão logística, identificou como fatores de risco seguida pela regressão logística, identificou como fatores de risco seguida pela regressão logística, identificou como fatores de risco seguida pela regressão logística, identificou como fatores de risco seguida pela regressão logística, identificou como fatores de risco independentes para a ocorrência de CPP idade > 56 anos independentes para a ocorrência de CPP idade > 56 anos independentes para a ocorrência de CPP idade > 56 anos independentes para a ocorrência de CPP idade > 56 anos independentes para a ocorrência de CPP idade > 56 anos (p=0,0039), tempo cirúrgico > 210 minutos (p=0,0044) e (p=0,0039), tempo cirúrgico > 210 minutos (p=0,0044) e (p=0,0039), tempo cirúrgico > 210 minutos (p=0,0044) e (p=0,0039), tempo cirúrgico > 210 minutos (p=0,0044) e (p=0,0039), tempo cirúrgico > 210 minutos (p=0,0044) e pneumopatia crônica (p=0,0257). Ao comparar a freqüência de pneumopatia crônica (p=0,0257). Ao comparar a freqüência de pneumopatia crônica (p=0,0257). Ao comparar a freqüência de pneumopatia crônica (p=0,0257). Ao comparar a freqüência de pneumopatia crônica (p=0,0257). Ao comparar a freqüência de CPP que ocorreu em cada uma das oito categorias de risco com a CPP que ocorreu em cada uma das oito categorias de risco com a CPP que ocorreu em cada uma das oito categorias de risco com a CPP que ocorreu em cada uma das oito categorias de risco com a CPP que ocorreu em cada uma das oito categorias de risco com a freqüência estimada, não houve diferença estatisticamente freqüência estimada, não houve diferença estatisticamente freqüência estimada, não houve diferença estatisticamente freqüência estimada, não houv...

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“…Type b H. influenzae is a more virulent organism associated with more severe and invasive infections, such as meningitis, pneumonia, epiglottitis and septic arthritis, in which bacteraemia is a prominent feature [61]. In contrast, nontypable strains lead to less severe infections resulting from proliferation and contiguous spread of the bacteria within the respiratory tract, such as otitis media, sinusitis and lower respiratory tract infections, including infective exacerbations of chronic bronchitis [62].…”

Section: Allergen Air Pollutantsmentioning

confidence: 99%

Bacterial-induced release of inflammatory mediators by bronchial epithelial cells

Khair¹,

Davies²,

Devalia³

1996

Eur Respir J

165

118

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Bacterial Infection in Chronic Obstructive Pulmonary Disease

Cited by 459 publications

References 90 publications

MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients

MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients

Validade de um índice prognóstico para ocorrência de complicações pulmonares no pós-operatório de cirurgia abdominal alta

Bacterial-induced release of inflammatory mediators by bronchial epithelial cells

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