Bacterial infection of the male reproductive system causing infertility

Farsimadan, Marziye; Motamedifar, Mohammad

doi:10.1016/j.jri.2020.103183

Cited by 62 publications

(59 citation statements)

References 159 publications

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“…The inflammation and infection caused by uropathogens play an essential role in infertility. Most common uropathogens are associated with dysspermia: they can influence the semen quality in spermatogenesis, reservation and fertilization (Farsimadan and Motamedifar, 2020). Some uropathogens can directly impair the performance of spermatozoa (Table 1), but the majority of uropathogens impair the semen quality during spermatogenesis.…”

Section: Uropathogens Semen Quality and Dysspermiamentioning

confidence: 99%

“…When considering the prevalence of bacterial species in the semen microbiome in healthy males, it is essential to detail the profile of the semen microbiome. The significance of semen bacterial communities remains to be investigated; in earlier studies, researchers had been inclined to consider asymptomatic bacteriospermia as a pre-inflammatory condition, while in recent studies, researchers have considered some uropathogens as part of the normal flora in semen (Farsimadan and Motamedifar, 2020). Farahani et al summarized the recent studies on the semen microbiome using high-throughput sequencing (Farahani et al, 2020).…”

Section: Seminal Lactobacillus Community Types and Dominant Speciesmentioning

confidence: 99%

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Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Zhang

Dai

Chen

2021

Front. Cell. Infect. Microbiol.

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Infertility has become a common problem in recent decades. The pathogenesis of infertility is variable, but microbiological factors account for a large proportion of it. Dysbiosis of vaginal microbiota is reportedly associated with female infertility, but the influence of normal vaginal microbiota on infertility is unclear. In this review, we summarize the physiological characteristics of the vaginal tract and vaginal microbiota communities. We mainly focus on the bacterial adherence of vaginal Lactobacillus species. Given that the adherent effect plays a crucial role in the colonization of bacteria, we hypothesize that the adherent effect of vaginal Lactobacillus may also influence the fertility of the host. We also analyze the agglutination and immobilization effects of other bacteria, especially Escherichia coli, on ejaculated spermatozoa, and speculate on the possible effects of normal vaginal microbiota on female fertility.

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Section: Uropathogens Semen Quality and Dysspermiamentioning

confidence: 99%

Section: Seminal Lactobacillus Community Types and Dominant Speciesmentioning

confidence: 99%

Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Zhang

Dai

Chen

2021

Front. Cell. Infect. Microbiol.

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“…Neonates can become infected with HSV at birth from an infected mother, with potential involvement of the central nervous system and fatal consequences [7]. Both CT and NG can cause irreparable damage to the fallopian tubes, leading to infertility in women [8], and a possible role of these organisms in the reduction of sperm quality and fertility in males has been suggested [9]. Furthermore, STIs increase the susceptibility to human immunodeficiency virus (HIV) infection and its transmission risk due to augmented viral shedding in genital secretions [10].…”

Section: Introductionmentioning

confidence: 99%

Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections

Caruso

Giammanco

Virruso

et al. 2021

IJERPH

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Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) diagnosis, confirmation of infection using laboratory tools is essential to choose the most appropriate course of treatment and to screen at-risk groups. Numerous laboratory tests and platforms have been developed for gonorrhea, chlamydia, syphilis, trichomoniasis, genital mycoplasmas, herpesviruses, and human papillomavirus. Point-of-care testing is now a possibility, and microfluidic and high-throughput omics technologies promise to revolutionize the diagnosis of STIs. The scope of this paper is to provide an updated overview of the current laboratory diagnostic tools for these infections, highlighting their advantages, limitations, and point-of-care adaptability. The diagnostic applicability of the latest molecular and biochemical approaches is also discussed.

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“…In women, C. trachomatis is a known cause of different urogenital pathologies such as acute urethritis, cervicitis and salpingitis that may lead to severe reproductive complications including pelvic in ammatory disease, chronic pelvic pain, ectopic pregnancy, miscarriage and tubal infertility 6,7 . In men, C. trachomatis is considered the most common agent of non-gonococcal urethritis and may cause epididymitis-orchitis, prostatitis, sperm tract obstructions and alterations in sperm quality 8,9 . On the other hand, Mycoplasma hominis and Ureaplasma urealyticum have also been recognized as sexually transmitted infections that could impair human fertility 1 .…”

Section: Introductionmentioning

confidence: 99%

“…In women, U. urealyticum and M. hominis may cause different pathologies including acute urethritis, bacterial vaginosis, pelvic in ammatory disease and tubal infertility 14,18,19 . Moreover, the asymptomatic colonization by mycoplasmas or ureaplasmas could induce pro-in ammatory immune responses in the endometrium that may impair pregnancy outcomes 2,9,14,20 .…”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.

Paira

Molina

Tissera³

et al. 2021

Preprint

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Female and male infertility have been associated to Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections. However, evidence from large studies assessing their prevalence and putative associations in patients with infertility is still needed. The study design was a cross-sectional study including 1554 female and 3610 male patients with infertility in Cordoba, Argentina. In women, the prevalence of C. trachomatis, U. urealyticum and M. hominis urogenital infection was 4.3%, 31.1% and 12.1% whereas in men it was 5.8%, 19.2% and 5.3%, respectively. C. trachomatis infection was significantly more prevalent in men whereas U. urealyticum and M. hominis infections were more prevalent in women. Besides, C. trachomatis and U. urealyticum infections were significantly higher patients younger than 25 years. Moreover, U. urealyticum and M. hominis infections were associated to each other in either infertile women or men. Our data revealed that C. trachomatis, U. urealyticum and M. hominis are prevalent uropathogens in infertile patients. Of clinical importance, C. trachomatis and U. urealyticum infections were more prevalent in young patients whereas U. urealyticum and M. hominis are reciprocal risk factors of their co-infection. These results highlight the importance of including the screening of urogenital infections in the diagnostic workup of infertility.

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Bacterial infection of the male reproductive system causing infertility

Cited by 62 publications

References 159 publications

Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections

Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.

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