Bacterial infections in patients with liver cirrhosis

Preveden, Tomislav

doi:10.2298/mpns1506187p

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…[4] Although pneumonia exhibits higher mortality in patients with cirrhosis, majority of the studies focused on bacterial pneumonia as the most common cause of pneumonia in cirrhotic patients; other pathogens especially are usually underestimated in such patients and are often not underreported. [5,6] There are very few studies which have shown the influence of respiratory viruses (RVs) in clinical outcome of cirrhotic patients in CCU. [7][8][9] Till now, there is no published study showing the prevalence of RVs and their bacterial coinfections in cirrhotic patients admitted in CCU care.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of respiratory viral infectionsin liver disease patients with cirrhosis admitted in critical care unit

et al. 2019

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BACKGROUND: Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients. MATERIAL AND METHOD:A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome. RESULTS:Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral-bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively, P < 0.001). CONCLUSION:Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.

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Section: Introductionmentioning

confidence: 99%

Spectrum of respiratory viral infectionsin liver disease patients with cirrhosis admitted in critical care unit

et al. 2019

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“…With a compromised immune system, patients with liver cirrhosis are more susceptible to a bacterial infection such as pneumonia, urinary tract infections, and spontaneous bacterial peritonitis (SBP) which can lead to significant morbidity and mortality [1,2]. Spontaneous bacterial empyema (SBEM) is often lessrecognized, which occurs in 2% of cirrhotic patients without hydrothorax and up to 13% of cirrhotic patients with hydrothorax [3,4].…”

Section: Discussionmentioning

confidence: 99%

A challenging case of spontaneous bacterial empyema in a cirrhotic patient

Ali

Akanbi

Godman

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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“…The present study showed that the frequencies of technique failure and infection, such as peritonitis and ESI, were not different between patients with PD with and without LC. Infection, including peritonitis, is a serious complication in patients with LC, who are vulnerable to bacterial infections, which are directly related to sepsis and death (22,23). Therefore, patients with LC tend to discontinue PD more quickly than do non-LC patients once infection occurs in real clinical situations (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Liver Cirrhosis on the Outcomes of Peritoneal Dialysis

et al. 2019

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Background Peritoneal dialysis (PD) has become an increasingly important treatment modality for end-stage renal disease. However, application of PD in patients with liver cirrhosis (LC) and subsequent outcomes have not been thoroughly evaluated. Methods A total of 1,366 patients (≥ 18 years old) who started PD at 4 tertiary referral centers between January 2000 and December 2015 were initially reviewed. Among them, 45 patients with LC were finally analyzed (LC-PD). Using the multivariate Cox hazard ratio (HR) model, outcomes such as technique failure, infection, and mortality in patients with LC-PD were compared with those in non-LC-PD patients (non-LC-PD) or patients with LC who received hemodialysis (LC-HD). All of the patients were selected by 1:1 matching of age, sex, catheter insertion date, and diabetes mellitus. Results During the mean follow-up duration of 43 ± 35.8 months, 12 patients with LC-PD experienced technique failure, and this rate was similar to that of non-LC-PD patients. In evaluating infection episodes, the most common causes for peritonitis and exit-site infection were Escherichia coli (5.8%) and Staphylococcus aureus (19.3%), respectively; these event rates of LC-PD did not differ from those of non-LC-PD. The all-cause mortality rate of the LC-PD group was not different from that of the non-LC-PD and LC-HD groups. Conclusion Dialysis outcomes such as technique failure, infection, and mortality are not affected by the presence of LC. Accordingly, PD therapy is a good option in patients with LC.

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Bacterial infections in patients with liver cirrhosis

Cited by 10 publications

References 18 publications

Spectrum of respiratory viral infectionsin liver disease patients with cirrhosis admitted in critical care unit

Spectrum of respiratory viral infectionsin liver disease patients with cirrhosis admitted in critical care unit

A challenging case of spontaneous bacterial empyema in a cirrhotic patient

Effect of Liver Cirrhosis on the Outcomes of Peritoneal Dialysis

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