Bacterial infections of the lower urinary tract treated with ciprofloxacin or cefalexin — a comparative study

Abstract

30/30 patients with lower UTI were enrolled in a randomized study to compare ciprofloxacin (250 mg/b.i.d.) and cefalexin (1 g/t.i.d.). In addition, 59 patients with cefalexin-resistant bacterial strains were treated in an open study arm. Ciprofloxacin showed convincingly better clinical and bacteriological efficacy than cefalexin. Both antibiotics were well tolerated. Ciprofloxacin has proved to be superior to cefalexin in the treatment of lower UTI.

Development of Cholinium-Based API Ionic Liquids with Enhanced Drug Solubility: Biological Evaluation and Interfacial Properties

“…Further, the LVF-based ILs have shown much lower MICs compared to CPLX-based ILs, which may be due to the cation−anion interactions and the drug class variation, as LVF belongs to the fluoroquinolone family and CPLX to the cephalosporin class and some fluoroquinolones are supposed to be better than cephalosporins. 54 Moreover, the biological effect of Cho-API-ILs/ILs has been related with different physicochemical parameters like their adsorption, aqueous solubility, hydrophobic character, cmc, and aggregation at the microbial cell wall or transport of these compounds in the test medium. The Cho-API-IL potential will be determined by how they adhere to the cell wall and then penetrate the cells to change the permeability of the membrane.…”

“…aureus. Further, the LVF-based ILs have shown much lower MICs compared to CPLX-based ILs, which may be due to the cation–anion interactions and the drug class variation, as LVF belongs to the fluoroquinolone family and CPLX to the cephalosporin class and some fluoroquinolones are supposed to be better than cephalosporins …”

A Randomized study comparing low dose ciprofloxacin and ofloxacin in the treatment of lower respiratory tract infections

“…But a number of hospital-acquired gram-negative pneumonias could be completely treated with an oral quinolone [1]. Another important area of future investigations may be to compare quinolones with the new cephalosporins in the treatment of respiratory tract infections in intensive care patients [1,4,12].…”

“…Since DNA gyrase maintains the chromosome in a supercoiled state and repairs small single-strand breaks in DNA that occur during replication, its inhibition provides a possible explanation for the bactericidal activity of these agents [1][2][3]. Quinolones are active against most gram-positive and gram-negative pathogens including those commonly associated with respiratory tract infections, especially Haemophilus influenzae, Moraxella catarrhalis and Klebsiella [3][4][5][6][7][8][9][10][11]. The present study was undertaken to provide more information on the efficacy of ciprofloxacin and ofloxacin in lower respiratory tract infections when used in low doses [3,9].…”